Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc5.2 | Adrenal 1 | ECE2019

Pheochromocytoma aggressiveness induced by tumor microenvironment depends on the SDH subunit involved

Martinelli Serena , Riverso Maria , Mello Tommaso , De Filpo Giuseppina , Canu Letizia , Maggi Mario , Mannelli Massimo , Rapizzi Elena

Pheochromocytoma/paraganglioma (Pheo/PGL) are rare neuroendocrine tumors generally benign. About 30–40% of Pheo/PGL are due to germ-line mutations in one of the susceptibility genes, including those encoding the succinate dehydrogenase subunits A-D (SDHA-D). Up to 80% of patients affected by SDHB mutated Pheo/PGL develop metastatic disease with no successful cure at present. In this study, we evaluated the different effect of tumor microenvironment on tu...

ea0063p604 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effects of testosterone treatment on fat tissue dysfunction and nonalcoholic fatty liver disease in obese men undergoing bariatric surgery

Maseroli Elisa , Corno Chiara , Comeglio Paolo , Cellai Ilaria , Filippi Sandra , Mello Tommaso , Galli Andrea , Facchiano Enrico , Beltrame Benedetta , Lucchese Marcello , Rastrelli Giulia , Maggi Mario , Vignozzi Linda

Objective: Substitution treatment of hypogonadism in clinical and experimental models has shown beneficial effects on insulin sensitivity and accumulation of visceral and liver fat. Aim of the study was to analyze the effects of testosterone replacement therapy on benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) clinical parameters, adipose tissue dysfunction and nonalcoholic fatty liver disease (NAFLD) in obese patients candidates for bariatric surgery.</p...

ea0041gp56 | Cardiovascular endocrinology | ECE2016

The dual FXR/TGR5 agonist INT-767 reduces visceral fat mass, promoting preadipocyte brown differentiation, mitochondrial function and insulin sensitivity in a rabbit model of high fat diet-induced metabolic syndrome

Vignozzi Linda , Cellai Ilaria , Filippi Sandra , Comeglio Paolo , Mello Tommaso , Bani Daniele , Guasti Daniele , Sarchielli Erica , Morelli Annamaria , Maneschi Elena , Vannelli Gabriella Barbara , Adorini Luciano , Maggi Mario

Expanding brown adipose tissue is a potential therapeutic strategy to counteract insulin resistance and metabolic syndrome (MetS). Farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) activation enhances insulin sensitivity, suggesting the capacity of FXR/TGR5 agonists to promote brown differentiation in adipose tissue. Treatment with increasing doses of the dual FXR/TGR5 agonist INT-767 (3, 10, 30 mg/Kg bw, daily for 5 days a week, by oral gavage, for 12 ...

ea0032p738 | Obesity | ECE2013

The FXR agonist obeticholic acid normalizes lipid droplet and triglyceride handling in visceral adipose tissue preadipocytes from a non-genomic rabbit model of metabolic syndrome

Maneschi Elena , Vignozzi Linda , Morelli Annamaria , Mello Tommaso , Filippi Sandra , Cellai Ilaria , Comeglio Paolo , Sarchielli Erica , Calcagno Alessandra , Vettor Roberto , Vannelli Gabriella Barbara , Adorini Luciano , Maggi Mario

Liver and visceral ectopic fatty tissue disposition is a major metabolic derangement leading to type 2 diabetes, hypertension, dyslipidaemia, recapitulated in the metabolic syndrome (MetS). We have demonstrated that the selective FXR agonist obeticholic acid (OCA, INT-747) ameliorates the metabolic profile and reduces visceral adipose tissue (VAT) in a high-fat diet (HFD)-induced rabbit model of MetS. We now report the effects of OCA treatment in HFD (0.5% cholesterol and 4% p...

ea0014p13 | (1) | ECE2007

Rosiglitazone interferes with the inflammatory response induced in human endothelial cells by TNFalpha and IFNgamma through a new mechanism involving extracellular signal-regulated kinases (ERKs)

Lombardi Adriana , Piscitelli Elisabetta , Francalanci Michela , Mello Tommaso , Santarlasci Veronica , Gelmini Stefania , Cantini Giulia , Galli Andrea , Cosmi Lorenzo , Annunziato Francesco , Forti Gianni , Serio Mario , Luconi Michaela

Microvascular endothelium is one of the main character and target involved in the inflammatory response. Upon specific activation, endothelial cells massively recruit Th1 IFNgamma secreting lymphocytes at the inflammatory site. In the present study, we investigate the intracellular signalling mediating TNFalpha (T) and IFNgamma (I) inflammatory response in a human endothelial cell line (HMEC-1) in vitro and the interfering effects of rosiglitazone (RGZ), a peroxisome pr...