Searchable abstracts of presentations at key conferences in endocrinology

ea0032p32 | Adrenal cortex | ECE2013

Diagnostic performance of first line biochemical tests to differentiate ACTH-ectopic syndrome among ACTH dependent Cushing’s syndrome

Belaya Zhanna , Rozhinskaya Liudmila , Dragunova Natalia , Dzeranova Larisa , Arapova Svetlana , Marova Evgenia , Kolesnikova Galina , Melnichenko Galina

Introduction: This study evaluates the diagnostic accuracy of clinical features and first line routine screening tests to differentiate ACTH-ectopic syndrome from Cushing’s disease (CD).Materials and methods: The retrospective clinical and biochemical presentations of 180 patients with histologically proven ACTH-dependent Cushing’s syndrome (CS) (159 CD, 21 ACTH-ectopic syndrome) were compared according to the cause of hypercortisolism. ROC-ana...

ea0063p549 | Diabetes, Obesity and Metabolism 2 | ECE2019

PRIMAVERA study: sibutramine therapy safety monitoring in patients with obesity

Troshina Ekaterina , Mazurina Natalya , Galieva Marina , Melnichenko Galina , Dedov Ivan

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

ea0063p685 | Pituitary and Neuroendocrinology 2 | ECE2019

Copeptin in differential diagnosis in polyuric states

Pigarova Ekaterina , Dzeranova Larisa , Melnichenko Galina , Dedov Ivan

Introduction: Measurement of copeptin is proposed for use in the differential diagnosis of polyuric syndrome.Aims: To evaluate the diagnostic value of copeptin levels in patients with polyuria syndrome.Materials and methods: The study included 17 patients with central diabetes insipidus (CDI), 3 patients with nephrogenic diabetes insipidus (NDI), 7 patients with primary polydipsia (PP) and 26 control subjects. In all individuals bl...

ea0063ep97 | Pituitary and Neuroendocrinology | ECE2019

Restoration of fertility in a woman with giant prolactinoma in response to cabergoline treatment (case report)

Astaf'eva Liudmila , Kadashev Boris , Kalinin Pavel , Sidneva Yuliya , Melnichenko Galina

A 32-year-old woman presented with primary amenorrhea, prolactin (PRL) level of 154150 mIU/l (40–530 mIU/l) diagnosed with an endo-supra-infra-laterosellar giant pituitary adenoma measuring maximum 6.2 cm. The patient was prescribed a treatment with cabergoline (CAB) at an initial dose of 0.5 mg per week. The treatment decreased the tumour size and brought to normal the level of PRL. After 7 months of CAB treatment menarche was achieved, after 12 months the patient became...

ea0037oc11.5 | Obesity | ECE2015

Preliminary analysis of the PRIMAVERA Study: reduxine safety monitoring in patients with alimentary obesity

Dedov Ivan , Melnichenko Galina , Romantsova Tatiana , Zhuravleva Marina

Background: The SCOUT trial showed that sibutramine produced weight loss with some increased cardiovascular morbidity but not mortality. But these results should not be extrapolated to a routine practice as a lot of the SCOUT participants had contraindications for sibutramine. In order to summarise data on efficacy and safety of sibutramine administration in routine clinical practice according to approved indications and to implement risks monitoring system in Russia, PRIMAVER...

ea0035p24 | Adrenal cortex | ECE2014

Bone mineral density, markers of bone remodeling, and quality of life in patients with Cushing's syndrome after 12 months of remission

Dragunova Natalja , Belaya Zhanna , Rozhinskaya Liudmila , Melnichenko Galina

This study estimates the recovery of bone mineral density (BMD), markers of bone remodeling and quality of life in patients with endogenous Cushing’s syndrome (CS) after 12 months of remission.Materials and methods: Twenty-one patients with CS were prospectively evaluated at active stage of the disease and after being in a full remission (substitutional therapy with hydrocortisone or normal 24 h urinary free cortisol (24 h UFC) and late-night cortis...

ea0035p119 | Calcium and Vitamin D metabolism | ECE2014

Levels of vitamin D in patients with various endocrine disorders

Pigarova Ekaterina , Dzeranova Larisa , Rozhinskaya Liudmila , Il'in Alexander , Melnichenko Galina

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

ea0035p302 | Clinical case reports Thyroid/Others | ECE2014

An unusual case of diabetes mellitus as a result of heterozygous missense mutation R482W in LMNA gene (familial partial lipodystrophy type 2), described for the first time in Russian population

Sorkina Ekaterina , Tiulpakov Anatoly , Kalashnikova Marina , Melnichenko Galina

Background: Familial partial lipodystrophy type 2 (Dunnigan syndrome and FPLD2) is a rare genetic disorder, associated with different metabolic abnormalities, especially insulin resistant diabetes mellitus, dyslipidaemia, hepatic steatosis, and cirrhosis, cardiovascular disease, and cardiomyopathy, kidney disease.Clinical case: A 20-year-old patient first presented with changed appearance due to abnormal subcutaneous fat tissue redistribution (lipodystro...

ea0035p919 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Copeptin in basal conditions and during water deprivation test in patients with polydipsic–polyuric disorders

Pigarova Ekaterina , Dzeranova Larisa , Rozhinskaya Liudmila , Melnichenko Galina , Dedov Ivan

Introduction: Copeptin is a proposed new diagnostic marker in differential diagnosis of diabetes insipidus as it is secreted in equimolar concentrations with vasopressin. Thus our aim was to assess diagnostic value of copeptin evaluation in patients with polydipsic-polyuric disorders.Materials and Methods: We’ve evaluated the copeptin (BRAHMS CT-proAVP Kryptor), sodium levels and blood/urine osmolality in 26 healthy volunteers (1M/25F, mean age 24.7...

ea0070aep630 | Pituitary and Neuroendocrinology | ECE2020

Clinical presentations of patients with MEN 1 syndrome and its phenocopies

Dimitrova Diana , Mamedova Elizaveta , Belaya Zhanna , Melnichenko Galina

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is a rare, autosomal dominant disease caused by mutations in the MEN1 gene. The syndrome predisposes an individual to the development of primary hyperparathyroidism (PHPT), gastroenteropancreatic neuroendocrine tumors (GEP-NETs), pituitary adenomas (PA), as well as other endocrine and non-endocrine tumors that usually manifest at a young age. If a patient with the MEN 1 phenotype does not carry m...