Searchable abstracts of presentations at key conferences in endocrinology

ea0035s18.1 | Endocrine disease during pregnancy | ECE2014

Pituitary tumours during pregnancy

Mezosi Emese

The morphology and function of pituitary gland are significantly altered in pregnancy. Complex changes can be seen at the level of pituitary and target hormones, binding globulins and the effect of placental hormones are also should be taken into consideration; this makes the diagnosis of pituitary dysfunction more complicated than in the non-pregnant stage. The incidence of pituitary adenomas in child-bearing age is 0.93/100 000. All pituitary tumors carry an increased risk f...

ea0056mte7 | (1) | ECE2018

Difficult cases of differentiated thyroid cancer

Mezosi Emese

The incidence of differentiated thyroid cancer (DTC) has increased worldwide which is mainly attributed to the more common detection of early stage DTC. The prognosis of early stage disease is excellent and the present ATA guidelines suggest less radical treatment and follow-up in these cases. TNM staging, risk classification, indication of radioiodine (RAI) treatment, evaluation of therapeutic response and TSH target range have been recently changed. However, 7–10% of DT...

ea0035p20 | Adrenal cortex | ECE2014

Measurement of serum total cortisol using HPLC coupled ESI–TOF mass spectrometry

Tarjanyi Zita , Montsko Gergely , Mezosi Emese , Kovacs Gabor L

Cortisol is a glucocorticoid hormone with low molecular weight (362 Da) synthesized from cholesterol in the adrenal gland. The release is regulated by the hypothalamic–pituitary-adrenal (HPA) axis. Approximately 95% of the circulating amount is bound to proteins (CBG and albumin), but only the remaining free fraction is biologically active. Serum cortisol level is routinely analysed in laboratory medicine, though the widespread immunoassays (RIA and ECLIA) have the disadv...

ea0041gp221 | Thyroid Cancer | ECE2016

Predictive value of SPECT/CT after radioiodine therapy in differentiated thyroid cancer

Szujo Szabina , Schmidt Erzsebet , Szabo Zsuzsanna , Szekeres Sarolta , Zambo Katalin , Mezosi Emese

Purpose: SPECT/CT has numerous advantages over planar and traditional SPECT images. The aim of this study was to evaluate the role of SPECT/CT after radioiodine treatment of patients with differentiated thyroid cancer (DTC) in early risk classification and in prediction of late prognosis.Methods: One hundred and eighty-one consecutive patients with DTC were investigated after their first radioiodine treatment. The risk for recurrence based on ATA 2009 cl...

ea0037ep733 | Pituitary: clinical | ECE2015

Evaluation of GH secretion after stroke

Nemes Orsolya , Tarjanyi Zita , Szapary Laszlo , Ruzsa Beata , Bodis Beata , Bajnok Laszlo , Mezosi Emese

Objective: According to recent studies, impaired secretion of GH is a frequent finding after ischaemic stroke. The aim of our study was to compare various available GH stimulation tests in post-stroke patients.Design: Seventeen patients were included in the study (12 males; mean age: 60.5 years; mean BMI, 27.7 kg/m2) with a mean 19.6 (±7.3) months after stroke. For screening, glucagon and small dose (0.15 μg/kg) GHRH-arginine (sdGHRH...

ea0032p1000 | Thyroid (non-cancer) | ECE2013

Genetic examination of the TSHR gene in patients with congenital hypothyroidism: systematic survey of a Hungarian cohort

Labadi Arpad , Gellen Balazs , Ruzsa Beata , Rideg Orsolya , Kovacs Gabor L , Mezosi Emese , Persani Luca

Loss-of-function mutations in the TSH receptor (TSHR) gene are one of the most common known causes of congenital hypothyroidism (CH). While heterozygous mutations result in nonautoimmune isolated hyperthyrotropinemia, homozygous and compound heterozygous mutations may cause overt CH of various severity depending on the localization and type of the mutations.In our study we performed the systematic genetic analysis of the TSHR gene of a cohort of 85 Hunga...

ea0032p1097 | Thyroid cancer | ECE2013

The role of radioiodine SPECT/CT in differentiated thyroid cancer

Mezosi Emese , Bajnok Laszlo , Rucz Karoly , Weninger Csaba , Schmidt Erzsebet , Szabo Zsuzsanna , Szekeres Sarolta , Zambo Katalin

Introduction: Beside remnant ablation and treatment of known metastases, radioiodine treatment of differentiated thyroid cancer is suitable for the discovery of unknown or suspected metastatic disease. In this study, the clinical utility of SPECT/CT, a hybrid imaging method was evaluated after radioiodine therapy.Patients and methods: Between July 2007 and March 2012, 260 investigations were performed at 188 patients. Male:female ratio was 47:141. Every ...

ea0014p358 | (1) | ECE2007

Water purification technology reduces iodine content of drinking water and contributes to iodine deficiency

Samson Laszlo , Czegeny Ildiko , Nagy Endre V , Mezosi Emese , Erdei Annamaria

Drinking water is the major natural source of iodine in many European countries. In the present study, we examined possible sites of iodine loss during the usual water purification process. Water samples from 6 sites during the technological process were taken and analyzed for iodine content. Under laboratory circumstances, prepared iodine in water solution has been used as a model to test the effect of the presence of chlorine. Samples from the purification sites revealed tha...

ea0014p472 | (1) | ECE2007

Relapse of hyperthyroidism in Graves’ disease after long-term drug treatment

Mezosi Emese , Nemes Orsolya , Bodis Beata , Nagy Zsuzsanna , Ruzsa Beata , Rucz Karoly , Bajnok Laszlo

The optimal treatment of hyperthyroidism in Graves’ disease is still an unresolved question. Hyperthyroidism recurs in 50% of patients after discontinuation of antithyroid therapy. In this retrospective study, Graves’ patients investigated in the endocrine unit of Pecs University between December 2004 and October 2006 were enrolled (68 women, 22 men, age 47 (15–79) years). Antithyroid drug therapy was applied for a minimum of one year and the treatment was withd...

ea0014p135 | (1) | ECE2007

Papillary thyroid cancer – the possible role of death ligands in tumor immunology

Mezosi Emese , Gyory Ferenc , Borbely Agnes , Ujhelyi Bernadett , Soos Gyorgyike , Nagy Endre V. , Varga Zsuzsa , Bajnok Laszlo

Papillary thyroid cancer (PTC) cells and immune cells can kill each other by death ligands. Death ligands induce apoptosis only in sensitive cells. The sensitivity to apoptosis is regulated in a complex and poorly understood manner. The aim of this study was to investigate the Fas ligand (FasL) and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) expression in PTC cells and tumor infiltrating immune cells. Twenty-six PTCs without and fifteen PTCs with cervical l...