Endocrine Abstracts

Introduction/objective: Elderly patients have a higher prevalence of hypernatremia. Previous studies suggested that impaired ADH secretion contributes to development of hypernatremia in the elderly. Copeptin is the C terminal part of the ADH precursor and is more stable in plasma than ADH. The aim of this study was to detect demographic and clinical characteristics of the elderly hypernatremic patient hospitalized in the internal medicine ward, and to increase the understandin...

Background: Primary hyperaldosteronism (PH) is a syndrome caused by excess aldosterone secretion, which leads to hypertension and hypokalemia and increased risk for target organ damage. The overproduction of aldosterone at the adrenal gland can be unilateral or bilateral. For unilateral disease the best treatment is unilateral adrenalectomy. According to international guidelines, most of the patients should have adrenal venous sampling (AVS) to distinguish between bilateral an...

Background: Thyroid dysfunction is associated with increased cardiovascular morbidity and mortality. Early detection may influence the clinical management of the patients. There is insufficient data about the prevalence and clinical significance of thyroid dysfunction in cardiovascular hospitalized patients.Aims: To study the prevalence of thyroid dysfunction in cardiovascular hospitalized patients, to characterize patients with high prevalence of thyroi...

Introduction: Many studies have examined maternal and fetal complication rates in treated and untreated overt and subclinical hypothyroidism. Maternal hypothyroidism may adversely affect the development of the fetal pituitary–thyroid axis. It has also been reported to be closely related to adverse pregnancy outcome.Aim: To study the prevalence and outcome of hypothyroidism in pregnancy during the last decade in a high volume obstetric center in Jeru...

Background: Hospital physicians are indoor workers, with higher prevalence of vitamin D deficiency as compared to community-based physicians. The correlation between vitamin D deficiency and osteoporosis later in life has not been fully studied, and bone mineral density (BMD) in elderly hospital physicians has not been systematically examined.Methods: A cross-sectional study measuring BMD in hospital male physicians aged 65 and older was carried out. BMD...

ACTH independent macronodular adrenal hyperplasia (AIMAH) is a rare cause of Cushing’s syndrome. Both Phosphodiesterase 11A4 (PDE11A4) mutations and inactivating mutations of armadillo repeat containing 5(ARMC5) have been associated with familial AIMAH. A family with autosomal dominant AIMAH was studied trying to elucidate the involved genetic basis.Methods and results: Adrenal hypercortisolism with giant bilateral AH was diagnosed in three adult me...

Background: The clinical presentation of hyperthyroidism has been studied in the ambulatory caresetting. Our hospital performs a TSH test for all newly admitted patients.Aim: To describe the clinical presentation of patients with overt hyperthyroidism during hospitalization and to study the association between thyroid hormone levels and the clinical picture.Methods: A retrospective study of 250 hospitalized patients from an 11-year...

The diagnosis of Cushing’s syndrome (CS) is based primarily on diagnostic tests evaluating the cortisol response to dexamethasone suppression. Tests based on oral administration of dexamethasone may be compromised by poor compliance. We evaluated the diagnostic accuracy of a novel intravenous dexamethasone suppression test (IDST). The test is performed by intravenous (iv) bolus injection of 8 mg dexamethasone, with blood cortisol determinations made before injection, then...