Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp50 | Bone & Calcium Homeostasis (1) | ECE2016

Renal concentration capacity in primary hyperparathyroidism and changes after surgery and during medical management and monitoring

Mirnaya Svetlana , Mokrysheva Natalya

Introduction: Patients with primary hyperparathyroidism (pHPT) run an increased risk of death, and in some studies cardiovascular diseases were inversely related to urine osmolality.Aim: Evaluate the renal concentration capacity in patients with mild and severe pHPT, and its changes after surgery for pHPT and during medical management and monitoring.Materials and methods: The study included 77 patients (median age 57 (52;61)) with ...

ea0041gp44 | Bone & Calcium Homeostasis (1) | ECE2016

Diabetes mellitus and carbohydrate metabolism in primary hyperparathyroidism

Mokrysheva Natalya , Mirnaya Svetlana , Lipatenkova Anna

Introduction: Primary hyperparathyroidism (PHPT) results in alterations in carbohydrate metabolism, characterized by insulin resistance, hyperinsulinemia, and glucose intolerance.Objective: The aim of our study was to evaluate carbohydrate metabolism status in patients with PHPT.Methods: One hundred and nine patients with PHPT were investigated, healthy controls included 36 individuals matched by sex age and BMI (BMI=27±5 kg/m...

ea0073ep30 | Calcium and Bone | ECE2021

Sporadic multiple parathyroid gland disease in young woman with primary hyperparathyroidism

Bibik Ekaterina , Eremkina Anna , Mokrysheva Natalya

BackgroundMost cases of primary hyperparathyroidism (PHPT) is caused by a single benign adenoma, multiple parathyroid neoplasms (MPN) occur less often in 10–15%, parathyroid carcinoma accounts for <3%. MPN can be sporadic or develop due to inherited genetic syndromes (most commonly multiple endocrine neoplasia syndrome type 1 (MEN-1) that usually manifest at a young age. The preoperative examination of patients with MPN is important for achievin...

ea0090ep583 | Endocrine-related Cancer | ECE2023

Recurrent parathyroid cancer in a child associated with mutation in CDC73 gene

Kim Ekaterina , Krupinova Julia , Eremkina Anna , Kalinchenko Natalya , Mokrysheva Natalia

Background: Parathyroid cancer (P?) in children is extremely rare, more often sporadic, but may be associated with a germline mutation. The only effective treatment is surgical approach due to the chemo-radio-resistance of PC.Clinical case: A 6-years-old girl presented with weakness, gait disturbance, pain in the limbs, an X-shaped curvature of the legs. At the age of 12, the patient’s well-being worsened sharply. The laboratory examination revealed...

ea0049ep257 | Calcium &amp; Vitamin D metabolism | ECE2017

Normocalcemic versus Hypercalcemic Primary Hyperparathyroidism: a comparative study

Mokrysheva Natalya , Mirnaya Svetlana , Eremkina Anna , Krupinova Julia , Kovaleva Elena

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is defined as a condition in which persistently normal serum calcium levels are observed in the presence of high levels of parathyroid hormone (PTH). NPHPT is a new entity which possibly represents a clinically symptomatic disease and which has generated a considerable scientific interest.Aim: To compare the clinical and laboratory data between the normocalcemic and hypercalcemic forms of PH...

ea0026p545 | Bone/calcium/Vitamin D | ECE2011

Some epidemiological aspects of primary hyperparathyroidism in Russia

Rostomyan Liliya , Mokrysheva Natalya , Mirnaya Svetlana , Kirdyankina Nataliya , Rozhinskaya Liudmila

Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder and has a variable clinical presentation. Asymptomatic PHPT became the predominant form of the disease with increase of it’s incidence after the introduction of automated serum calcium measurement in North America and Europe. Data from Russia is lacking.Aim: To present the clinical profile of PHPT in Russia.Materials and methods: This retrospectiv...

ea0022p452 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Cushing’s disease as the first manifestation of familial multiple endocrine neoplasia syndrome type 1

Rostomyan Liliya , Mokrysheva Natalya , Tiulpakov Anatoly , Rozhinskaya Ludmila

MEN1 syndrome is an autosomal dominant inherited disease characterised by primary hyperparathyroidism in association with endocrine enteropancratic tumors and anterior pituitary adenomas. Tumours of the pituitary gland as the first manifestations of MEN1 are very rare in children.Clinical case report: A 13-year-old boy presented with clinical signs suggestive of Cushing’s syndrome. He had decreased growth rate, muscle weakness, headaches and truncal...

ea0056p237 | Calcium &amp; Vitamin D metabolism | ECE2018

Intrathyroidal parathyroid carcinoma in a chronic hemodialysis patient: a case report

Mokrysheva Natalya , Krupinova Julia , Kuznecov Sergei , Selivanova lily , Mirnaya Svetlana

Background: Parathyroid carcinoma (PC) is an infrequent pathology, responsible for 0.5–5% of primary hyperparathyroidism cases. Despite the high prevalence of secondary hyperparathyroidism in patients with a chronic kidney disease (CKD), PC among them is extremely rare, with less than 30 cases reported in the literature. The diagnosis of PC in CKD patients is more complex, because of using cinacalcet that reduces the level of calcium and parathyroid hormone (PTH). We repo...

ea0073aep139 | Calcium and Bone | ECE2021

Metabolic disorders in patients with primary hyperparathyroidism

Bibik Ekaterina , Dobreva Ekaterina , Eremkina Anna , Aynetdinova Alina , Mokrysheva Natalya

BackgroundThe nonclassical complications of primary hyperparathyroidism (PHPT) can include metabolic syndrome associated with cardiovascular diseases. According to clinical studies, an increased incidence of diabetes mellitus, insulin resistance, obesity, dyslipidemia and other disorders are observed in patients with PHPT regardless of the severity of the disease. The aim of this study is to estimate metabolic parameters in patients with PHPT compared to...

ea0049ep346 | Endocrine tumours and neoplasia | ECE2017

Multiple endocrine neoplasia type 1 phenocopies: role of the genes associated with familial primary hyperparathyroidism

Mamedova Elizaveta , Mokrysheva Natalya , Vasilyev Evgeny , Petrov Vasily , Belaya Zhanna , Rozhinskaya Liudmila , Tiulpakov Anatoly

Introduction: The genetic causes of development of multiple endocrine neoplasia type 1 (MEN-1) phenocopies remain largely unknown.Aim of the study: To evaluate the role of genes associated with familial primary hyperparathyroidism (PHPT) in the development of MEN-1 phenocopies with the combination of PHPT and pituitary adenomas (PA).Materials and methods: 20 patients (19 females and 1 male) were included in the study. All patients ...