Searchable abstracts of presentations at key conferences in endocrinology

ea0014p118 | (1) | ECE2007

Novel germline VHL mutations associated to uncommon clinical presentations

Ercolino Tonino , Becherini Lucia , Simi Lisa , Sole Gaglianò Maria , Nesi Gabriella , Valeri Andrea , Mannelli Massimo

The von Hippel-Lindau (VHL) syndrome is an inherited multi-tumor disorder characterized by clinical heterogeneity and high penetrance. Pheochromocytoma (Pheo) is present in 10-15% of cases. It can be isolated or associated with other lesions such as hemangioblastomas, kidney cysts or cancer, and pancreatic lesions. Pheos secrete norepinephrine and are generally located in the adrenals. While performing genetic testing in patients affected by apparently sporadic pheos or PGLs, ...

ea0070oc1.3 | Adrenal and Cardiovascular Endocrinology | ECE2020

Tumor microenvironment adipose stem cells modulate adrenocortical carcinoma progression

Cantini Giulia , Armignacco Roberta , de Assis Goncalves Diego , Guasti Daniele , Nesi Gabriella , Romagnoli Paolo , Mannelli Massimo , Maggi Mario , Luconi Michaela

The metabolic interplay occurring between the tumor microenvironment and cancer cells may represent a potential target for novel anti-cancer approaches. Among stromal components, adipocytes and adipose precursors have been shown to actively participate in tumor progression in several solid malignancies. In adrenocortical carcinoma (ACC), a rare endocrine neoplasia with a poor prognosis, cancer cells often infiltrate the fat mass surrounding the adrenal organ, enabling a possib...

ea0032p13 | Adrenal cortex | ECE2013

Detection of circulating tumor cells in adrenocortical carcinoma: a monocentric preliminary study

Poli Giada , Pinzani Pamela , Scatena Cristian , Salvianti Francesca , Corsini Elisa , Canu Letizia , Piccini Valentina , Nesi Gabriella , Mannelli Massimo , Luconi Michaela

Objective: Adrenocortical carcinoma (ACC) is a rare malignancy, whose prognosis is mainly dependent on the stage at diagnosis. The identification of disease-associated markers representing solid biomarkers for early diagnosis and drug monitoring is mandatory to improve survival rate and life quality of patients. CTC are tumor cells originating from primary tumor or metastases. The tumor-induced angiogenesis and invasion allow aggressive tumors to release CTC into blood stream ...

ea0032p552 | Endocrine tumours and neoplasia | ECE2013

Androgen receptor expression in stromal and epithelial prostate cancer tissue specimens

Lara Tamburrino , Francesca Salvianti , Sara Marchiani , Gabriella Nesi , Michele Lanciotti , Marco Carini , Pamela Pinzani , Elisabetta Baldi , Gianni Forti

Prostate cancer (PCa) is one of the leading causes of tumor death in Western countries. Modifications in expression and functional alterations that involve the androgen receptor (AR) have been implicated in the progression of PCa and in the development of androgen independence; however, the role of AR in these processes is still debated, as contrasting results have been reported in several studies evaluating the relation between AR expression and disease progression (Tamburrin...

ea0020p54 | Adrenal | ECE2009

Rosiglitazone interferes with human adrenocortical carcinoma growth in a xenograft mouse model

Mangoni Monica , Gelmini Stefania , Nesi Gabriella , Poli Giada , Cantini Giulia , Lombardi Adriana , Orlando Claudio , Serio Mario , Mannelli Massimo , Luconi Michaela

Adrenocortical carcinoma (ACC) is a rare and aggressive tumour with a poor prognosis, characterized by radio/chemotherapy resistance. The lack of an effective medical treatment is due to the poor knowledge of the mechanisms underlying malignant tumour transformation and aggressiveness. In vitro studies on the ACC H295R cell model have demonstrated that RGZ, an antidiabetic drug belonging to the thiazolidinedione ligands of PPARgamma, blocks cell proliferation/migration ...

ea0073pep11.1 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Fascin-1, a novel-circulating marker for the prognosis of the metastatic adrenocortical carcinoma

Cantini Giulia , Canu Letizia , De Filpo Giuseppina , Ercolino Tonino , Fei Laura , Nesi Gabriella , Maggi Mario , Mannelli Massimo , Luconi Michaela

Fascin-1(FSCN1) is an actin-bundling protein expressed in several solid carcinomas and often associated to an invasive and aggressive phenotype as it is involved in cytoskeleton rearrangement and filopodia formation. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy characterized by a poor prognosis, particularly when metastatic at diagnosis. Complete surgical resection of the tumor mass is the main therapy for ACC patients in addition to the adjuvant administratio...

ea0049gp8 | Adrenal 1 | ECE2017

Clinical and translational relevance of circulating miR483 in adrenocortical cancer

Canu Letizia , Salvianti Francesca , Poli Giada , Armignacco Roberta , Cantini Giulia , Di Franco Alessandra , Gelmini Stefania , Ercolino Tonino , Terzolo Massimo , Nesi Gabriella , Pinzani Pamela , Mannelli Massimo , Luconi Michaela

Adrenocortical cancer (ACC) is a rare aggressive malignancy, with poor prognosis when metastaic at diagnosis. Recent ACC pan-genomics analysis contributed to redefine the risk groups on molecular bases, including tumor micro RNA (miR), which can be detectable not only in the primary lesion but also in the bloodstream.We develop a quantitative real-time assay for the measurement of absolute levels in plasma samples of miR483 and its mature miR483-5p form....

ea0035oc11.4 | Diabetes and Obesity 2 | ECE2014

A novel adult human adipose stem cell model from inducible brown fat surrounding pheochromocytoma tumors

Di Franco Alessandra , Guasti Daniele , Mazzanti Benedetta , Ercolino Tonino , Nesi Gabriella , Bani Daniele , Forti Gianni , Mannelli Massimo , Valeri Andrea , Luconi Michaela

The recent discovery of the presence of brown adipose tissue (BAT) also in human adults is pivotal for development of anti-obesity therapies. This type of fat, in fact, mainly consists of brite cells (brown adipocytes appearing for a browning process in white fat) which are involved in adiposity control. The origin of brite cells in adult white adipose tissue (WAT) is still unclear as human cell models are lacking.Our study demonstrated the presence of B...

ea0073pep11.3 | Presented ePosters 11: Adrenal and Cardiovascular Endocrinology | ECE2021

Identification of carbonic anhydrases III and IX in the adipose microenvironment of adrenocortical carcinoma

Fei Laura , Cantini Giulia , Nocentini Alessio , Canu Letizia , Nardini Patrizia , De Filpo Giuseppina , Ercolino Tonino , Nesi Gabriella , Maggi Mario , Bani Daniele , Mannelli Massimo , Supuran Claudiu T , Luconi Michaela

The adipose tissue (AT) is an important endocrine organ. Upon energy imbalance, the adipose cells become dysfunctional, supporting the development of metabolic pathologies and tumours. The adipose cell is among the main actor of the tumor microenvironment, and is able to establish a crosstalk with the cancer cell resulting in a reciprocal reprogramming. Adrenocortical carcinoma (ACC) is a rare endocrine malignancy affecting the adrenal cortex. In the most aggressive forms, can...

ea0032p655 | Male reproduction | ECE2013

Fat boosts, while androgen receptor activation counteracts, BPH-associated prostate inflammation

Vignozzi Linda , Gacci Mauro , Cellai Ilaria , Santi Raffaella , Corona Giovanni , Morelli Annamaria , Rastrelli Giulia , Comeglio Paolo , Sebastianelli Arcangelo , Maneschi Elena , Nesi Gabriella , De Nunzio Cosimo , Tubaro Andrea , Mannucci Edoardo , Carini Marco , Maggi Mario

Background: Metabolic syndrome (MetS) and benign prostate hyperplasia (BPH) are often comorbid. Chronic inflammation, a determinant pathogenic factor for BPH, is a putative link between the two conditions.Methods: In a multi-center cohort of BPH patients (n=244) who underwent prostatectomy, we evaluated whether MetS is associated with prostatic inflammation in BPH specimens. In addition, we investigated the in vitro inflammatory effects...