Searchable abstracts of presentations at key conferences in endocrinology

ea0032p632 | Growth hormome IGF axis – basic | ECE2013

Glucose metabolism abnormalities in a population of acromegalic patients

Nogueira Claudia , Belo Sandra , Vinha Eduardo , Magalhaes Angela , Carvalho Davide

Introduction: There is a well-established association between acromegaly and insulin resistance (IR). The abnormalities in glucose metabolism may be an important risk factor of cardiovascular morbid-mortality in these patients.Objective: Evaluation of glucose metabolism abnormalities in a population of naïve acromegalic patients and its relationship with delay in diagnosis, gender, levels of insulin like growth factor 1 (IGF1) and GH.<p class="a...

ea0056ep115 | Pituitary and Neuroendocrinology | ECE2018

Macroprolactinemia diagnosed in a patient evaluated for primary infertility

Nogueira Claudia , Cunha Filipe , Ferreira Ivan , Mesquita Joana

Introduction: Hyperprolactinemia is associated with suppression of the hypothalamic-pituitary-gonadal axis and it’s a frequent cause of infertility, occurring in about 30–40% of infertile women. The bioactive fraction of prolactin is a 23-kDa monomer. However, there are other isoforms with reduced or absent bioactivity, such as macroprolactin, which can be detected by the precipitation reaction by polyethylene glycol. Macroprolactinemia should be suspected in the pre...

ea0049ep1081 | Pituitary - Clinical | ECE2017

Hypopituitarism and central diabetes insipidus in an HIV patient – a late complication of cerebral toxoplasmosis and/or antiretrovirals?

Oliveira Sofia Castro , Souteiro Pedro , Neves Joao Sergio , Nogueira Claudia , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

ea0041ep1035 | Thyroid (non-cancer) | ECE2016

Propylthiouracil induced ANCA-associated vasculitis

Souteiro Pedro , Freitas Joana , Amaral Susana , Belo Sandra , Nogueira Claudia , Pereira Rodrigues , Meirinho Ivone

Introduction: Propylthiouracil is a drug used in the treatment of hyperthyroidism and autoimmunity phenomena have been described as a side effect of its use. Despite anti-neutrophil cytoplasmic antibodies (anca) positivity is frequent in patients treated with propylthiouracil, the occurrence of clinically evident vasculitis is rare.Case report: A 65-year-old woman, diagnosed with hyperthyroidism 2 years ago and treated with propylthiouracil (50+...

ea0032p889 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Tumors with simultaneous hypersecretion of somatotropin and prolactin are associated with earlier diagnosis compared with tumors with isolated hysecretion of somatotropin

Belo Sandra , Nogueira Claudia , Magalhaes Angela , Vinha Eduardo , Pereira Josue , Carvalho Davide

Introduction: Amenorrhoea and galactorrhoea are manifestations that may allow earlier diagnosis of pituitary tumors associated with excess somatotropin (ST) and prolactin (PRL) levels.Objective: To evaluate clinical, analytical and imaging characteristics of ST and PRL producing tumors and its affect on diagnosis.Methods: Retrospective study including acromegalic patients diagnosed between 1982 and 2012. Information on clinical, an...

ea0032p926 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Somatotropin and IGF1 levels at diagnose and after surgery in acromegalic patients: is it possible to predict the likelihood of cure at diagnosis?

Belo Sandra , Nogueira Claudia , Magalhaes Angela , Vinha Eduardo , Pereira Josue , Carvalho Davide

Introduction: Generously supported by IPSEN)-->Elevated levels of somatotropin (ST) and IGF1 in acromegalic patients are associated with high morbidity and mortality. The normalization of ST and IGF1 allows the reversal of most of their negative effects.Objective: To evaluate characteristics present at diagnosis, predictive of cure, after surgery, in patients with ST-producing tumors.Meth...

ea0032p927 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Therapeutic response to recombinat somatropin in children with isolated deficiency of GH

Belo Sandra , Nogueira Claudia , Corujeira Susana , Costa Carla , Castro-Correia Cintia , Fontoura Manuel

Introduction: Generously supported by IPSEN)-->Treatment with recombinant ST is subject to strict criteria. Differences in the response to therapy based on the maximum level of ST in diagnostic tests (ST ≤5 vs ST >5 ng/ml), could predict whose patients would benefit more from therapy.Purpase: Assess differences in the response to therapy with rST in patients with IDGH.Methods: S...

ea0032p950 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Diagnosis and treatment of a population of acromegalic patients

Nogueira Claudia , Belo Sandra , Pereira Josue , Vinha Eduardo , Magalhaes Angela , Carvalho Davide

Introduction: Generously supported by IPSEN)-->Acromegaly is a chronic disease caused by GH hypersecretion resulting in increased IGF1 levels. The actions of these hormones result into a broad spectrum of clinical manifestations.Objective: To evaluate clinical and analytical parameters, imaging, and treatment outcome in a population of acromegalic patients.Methods: Retrospective study of ...

ea0026p652 | Clinical case reports | ECE2011

Long term evolution of a coincident ACTH-dependent and independent Cushing’s syndrome

Nogueira Claudia , Vinha Eduardo , Pereira Josue , Bernardes Ines , Gomes Taveira , Pardal Joana , Bettencourt Herberto , Carvalho Davide

Introduction: The coexistence of Cushing’s disease with an ACTH-secreting adrenal adenoma is not frequent.Case report: A 32-year-old woman was observed in our Department in 2000 for obesity. Hypercortisolism was documented and the basal hormonal study and functional testing oriented towards a pituitary origin (ACTH 24.8 pg/ml). Pituitary magnetic resonance imaging (MRI) showed an asymmetric pituitary gland and a pituitary stalk deviation to the left...

ea0056p64 | Adrenal cortex (to include Cushing's) | ECE2018

Bilateral macronodular adrenal hyperplasia with autonomous cortisol secretion

Nogueira Claudia , Cunha Filipe , Souteiro Pedro , Oliveira Sofia Castro , Mesquita Joana

Introduction: Bilateral macronodular adrenal hyperplasia is a rare cause of Cushing’s syndrome (CS) characterized by multiple adrenal nodules >1 cm. It can be diagnosed in patients with overt CS but is more often diagnosed incidentally, especially in the 5th or 6th decades of life.Clinical case: 61-year-old woman with type 2 diabetes, arterial hypertension and dyslipidemia treated with metformin+sitagliptin 1000/50 mg bid, valsartan+hydrochlorot...