Endocrine Abstracts

Rhythmic change of the internal milieu is a fundamental principle in all living organisms. A variety of physiological events show daily rhythms, such as blood pressure, hormonal secretion, cell cycle, and migration of stem cells from the bone marrow to the systemic circulation. This timing is determined by the endogenous oscillatory system called the circadian clock. Within the last ten years, the molecular dissection of circadian clock has progressed dramatically, and it is n...

Introduction: Peripheral arterial disease (PAD) is increased associated with an accumulation of patients with end stage kidney disease and diabetes. Recently, the cardio-ankle vascular index (CAVI) has been developed as an index reflecting the stiffness of the aorta independently of blood pressure. The aim of this study was to assess the prevalence of PAD in hemodialysis patients with diabetes.Methods: To examine the usefulness of CAVI to screen for the ...

BackgroundBoth obesity and diabetes are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. The aim of the present study was to investigate the circulating levels of IL-18 in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetesMethodsIL-18 levels were determined using a commercia...

Objective: Osteoporosis and osteopenia (OS/OP) are frequent in patients with cortisol-producing adrenal adenomas (CPA) associated with severity of cortisol excess (CE). However, the relationship between OS/OP and CE severity considering sex differences is unknown.Patients and Methods: This was a retrospective cross-sectional observational study conducted as a part of the Advancing Care and Pathogenesis of Intractable Adrenal Disease in Japan (ACPA-J) stu...

Context: Prior to thyroidectomy for Graves’ disease, thyroid function should be adequately controlled to avoid complications such as thyroid storm. However, preoperative thyroid function control is sometimes difficult.Objective: This study assessed the postoperative risks are increased or not if biochemically hyperthyroid patients undergoing total thyroidectomy in comparison to euthyroid patients.Methods: A retrospective, coho...

Purpose: Molecularly targeted drugs are indispensable therapeutic tools for the treatment of unresectable differentiated thyroid cancer. Lenvatinib (LEN) is listed as a preferred regimen in the NCCN guidelines, and is a highly effective anti-tumor agent, but is also associated with a high rate of adverse events (AEs), which may be related to prognosis. AE management is key to LEN therapy. Although there is no recommendation in the package insert regarding the recommended time ...