Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep203 | Neuroendocrinology | ECE2017

Quality of life in patients with neuroendocrine tumors treated with 177Lu-[DOTA0,Tyr3]-octreotate: a Single Tertiary Care Portuguese Center Experience

Lages Adriana , Moreira Helder , Costa Gracinda , Oliveira Patricia , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Carrilho Francisco

Introduction and purpose: 177Lu-[DOTA0,Tyr3]octreotate (177Lu-DOTA-TATE) is a radiopharmaceutical frequently used in peptide receptor radionuclide therapy (PRRT), which is a promising treatment modality in patients with metastasized neuroendocrine tumors (NETs). We purpose to evaluate the quality of life (QoL) in patients with somatostatin receptor positive inoperable or metastatic NETs throughout the three cycle’s (with three months intervals) proto...

ea0049ep44 | Adrenal cortex (to include Cushing's) | ECE2017

Late-night salivary cortisol: cut-off definition and diagnostic value in Cushing’s syndrome

Lages Adriana , Frade Joao , Paiva Isabel , Oliveira Patricia , Oliveira Diana , Martins Diana , Ventura Mara , Cunha Nelson , Rebelo-Marques Alexandre , Antunes Susana , Leitao Fatima , Carrilho Francisco

Background: The diagnosis of Cushing’s syndrome (CS) remains a challenge in clinical endocrinology. Several screening tests have been proposed to establish hypercortisolism. Late-night salivary cortisol (LNSC) is used as screening tool, however, individualized cut-off levels for each population must be defined.Methods: Three group of subjects were studied: healthy volunteers, suspected CS and proven CS. All patients collected saliva at 23.00 h using...

ea0056p401 | Diabetes (to include epidemiology, pathophysiology) | ECE2018

Glycemic variability and diabetes-related antibodies titer at diagnose in type 1 diabetic patients: is there a correlation?

De Sousa Lages Adriana , Cardoso Luis , Baptista Carla , Barros Luisa , Oliveira Patricia , Oliveira Diana , Ventura Mara , Cunha Nelson , Catarino Diana , Fadiga Lucia , Carrilho Francisco

Introduction: Type 1 Diabetes (DM1) is associated with a destructive autoimmune process of pancreatic b-cells. The presence of anti-islet cells (ICA) antibodies (Ab), as well as for distinctive antigens – GAD65, IA2 or Insulin (IAA) - is related to the disease development.Aim: To evaluate the effect of DM1 antibodies on the measures of glycemic variability (GV) obtain through continuous glucose monitoring (CGM).Materials and m...

ea0081ep62 | Adrenal and Cardiovascular Endocrinology | ECE2022

Synchronous adrenal gland masses in a patient: clinical case

Ferreira Mafalda Martins , Lavrador Mariana , Araujo Catia , Guiomar Joana Reis , Moreno Carolina , Oliveira Patricia , Paiva Isabel

We describe the case of a 69-year-old woman with bilateral adrenal incidentalomas identified in CT-scan: on the right, a 57 mm heterogeneous mass with <10 Hounsfield units(HU) with absolute washout of 16%; on the left a 13 mm mass with 35UH, intense contrast enhancement but washout of 66%. She had a recent onset of diabetes, hypertension, androgenic alopecia and facial hair. The systolic blood pressure remained persistently >160 mmHg despite receiving four antihyperten...

ea0081ep63 | Adrenal and Cardiovascular Endocrinology | ECE2022

Malignant pheochromocytoma with bone, pulmonary and brain metastases

Araujo Catia , Ferreira Mafalda Martins , Lavrador Mariana , Moreno Carolina , Oliveira Patricia , Baptista Carla , Paiva Isabel

Introduction: Pheochromocytomas are rare neuroendocrine tumors whose malignancy is defined by the presence of metastases that may appear several years later. The appropriate follow-up time remains uncertain.Clinical Case: We present the case of a woman with a history of pheochromocytoma who underwent complete resection at 48 years old. The genetic evaluation was negative for mutations on RET, VHL, SDHB or SDHD genes. At 66 years old, a thoracic vertebral...

ea0090oc2.3 | Oral Communications 2: Thyroid | ECE2023

The variable clinical spectrum of Thyroid Hormone Resistance Syndrome type β: two different presentations of the same disease

Martins Ferreira Mafalda , Lopes Sofia , Araujo Catia , Oliveira Patricia , Moreno Carolina , Paiva Isabel

Thyroid hormone resistance syndrome(THRS) occurs in 1:40000 live births and can be diagnosed after a period of enigmatic changes in thyroid hormones(TH). Patients may be clinically euthyroid, have clinical hypo or hyperthyroidism. Mostly, it is an autosomal dominant disease due to germline mutations in THRβ-gene(exons 7-10). Resistance to peripheral action of TH leads to absence of TSH suppression (which can be normal/elevated) despite elevated fT4 and fT3.<p class="a...

ea0090p600 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Mitochondrial fitness in mouse Leydig cells is imbalanced by liraglutide upon glucose stimuli

Lopes Bruno , Braga Patricia , Oliveira Pedro F. , Alves Marco , Bernardino Raquel

Metabolic diseases represent a threatening worldwide epidemic that affects the entire body. It is known that metabolic diseases, namely diabetes, and obesity affect spermatogenesis via suppressing testosterone synthesis, inducing oxidative stress and other changes that lead to decreased male fertility. Glucagon-like peptide 1 (GLP1) receptor agonists, like liraglutide, are pharmacological agents recommended to normalize glucose levels in patients with type 2 diabetes mellitus....

ea0090p692 | Pituitary and Neuroendocrinology | ECE2023

Characterisation of the clinical and biologic behaviour of acromegaly caused by pluri-hormonal tumours in a cohort of 75 patients

Martins Ferreira Mafalda , Carreira Ana , Cardoso Luis , Oliveira Patricia , Melo Miguel , Paiva Isabel

Introduction: The clinical and biochemical spectrum of pituitary acromegaly is wide and variable. There are pure somatotroph tumors(ST), immunohistochemically positive only for GH, and pluri-hormonal(PL), also positive for other hormones, and they appear to have different presentations and responses to treatment.Aims: To compare the clinical presentation, imaging characteristics and response to treatment of acromegalic patients according to the pituitary...

ea0090p174 | Reproductive and Developmental Endocrinology | ECE2023

Congenital Adrenal Hyperplasia – When does Gender Identity Begin?

Lopes Sofia , Ferreira Mafalda , Araujo Barbara , Ruas Luisa , Paiva Sandra , Oliveira Patricia , Paiva Isabel

Introduction: Congenital adrenal hyperplasia (CAH) is a genetic condition which impairs enzymatic steroidogenesis of the adrenal cortex, leading to excessive androgen production. CAH phenotype is heterogeneous. In the mildest forms, it can present with hirsutism, acne and menstrual irregularities. Problems related to gender identification arise in about 5% of people with CAH with a 46,XX karyotype.Objective: We present the case of a young female-to-male ...

ea0090ep187 | Calcium and Bone | ECE2023

Hyperparathyroidism Jaw Tumour Syndrome in Pregnancy: A rare coexistence

Lopes Sofia , Monsanto Alice , Ferreira Mafalda , Ventura Mara , Ruas Luisa , Oliveira Patricia , Paiva Isabel

Introduction: Only <1% of cases of primary hyperparathyroidism (PHPT) occur during pregnancy. PHPT increases risk of complications such as miscarriage, premature birth and life-threatening maternal hypercalcemic crises. Hyperparathyroidism Jaw Tumor Syndrome (HPT-JT) is a rare inherited cause of PHPT, resulting from CDC73 gene mutations. There are a few reports described about HPT-JT in pregnancy. Although parathyroidectomy is the definite treatment for PHPT, given the sca...