Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep615 | Endocrine-Related Cancer | ECE2022

Frequency of CYP1B1 gene polymorphism in obese and non-obese women with hormone-dependent endometrial cancer

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

ea0081rc13.4 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Analysis of the body composition and glucose metabolism in relation to bcli glucocorticoid receptor polymorphism in women with adrenal incidentalomas

Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Elezovic Valentina , Antic Jadranka , Opalic Milica , Radic Lena , Macut Djuro P

Single nucleotide polymorphisms in the glucocorticoid receptor (GR) gene influence tissue sensitivity of GR. Several studies have shown different effects of BclI GR polymorphism on body composition and metabolic parameters. The objective of this study was to explore the effect of BclI GR polymorphism on the body composition and glucose metabolism. Biochemical tests and hormonal evaluation were performed in 106 consecutive women with adrenal incidentalomas (AI...

ea0081p665 | Pituitary and Neuroendocrinology | ECE2022

Long-term follow up after remission of Cushing’s disease - experience of a single centre

Popovic Bojana , Ognjanovic Sanja , Ilic Dusan , Elezovic Valentina , Opalic Milica , Radic Lena , Milicevic Mihailo , Macut Djuro P.

Introduction: Chronic endogenous hypercortisolism in CushingÂ’s syndrome imposes a great clinical burden of comorbidities, some of which might persist even after disease remission. Our aim was to analyze factors that predict long-term comorbidities after surgical remission of CushingÂ’s disease (CD).Subjects and methods: We retrospectively analyzed 37 patents (91.9% females) aged 39.5±13.9 years (10-70) with diagnosed CD, treated in our inst...

ea0073aep402 | Endocrine-Related Cancer | ECE2021

Gonadal dysfunction in male patients with neuroendocrine tumors

Popovic Bojana , Antic Ivana Bozic , Isailovic Tatjana , Bogavac Tamara , Ilic Dusan , Kovacevic Valentina Elezovic , Opalic Milica , Ognjanovic Sanja , Macut Djuro

IntroductionHypogonadism is a potential manifestation of many chronic diseases including cancer, presumably related to their severity. Since novel anti-cancer treatments have significantly increased survival rates of affected patients, issue of hypogonadism becomes more significant, given the importance of issues like quality of life and potential for reproduction. The aim of our study was to analyze gonadal axis function in male patients with neuroendoc...

ea0081ep889 | Reproductive and Developmental Endocrinology | ECE2022

Association of SPISE and HOMA-IR indexes with metabolic characteristics of different age groups of women with polycystic ovary syndrome

Opalic Milica , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Bjekic - Macut Jelica , Elezovic Valentina , Radic Lena , Milutinovic Danijela Vojnovic , Stanojlovic Olivera , Macut Djuro P.

Introduction: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS cardinal manifestations include hyperandrogenism, oligo/anovulation, and/or polycystic ovarian morphology, and is closely linked to metabolic disorders such as obesity and insulin resistance (IR). It was observed that single-point insulin sensitivity estimator (SPISE) index is associated with metabolic abnormalities and could predict glucose regulation ...

ea0073ep126 | Endocrine-Related Cancer | ECE2021

Hyperprogression of Merkel cell carcinoma during immunotherapy

Ivana Bozic-Antic , Jovanovic Marko , Petkovic Ana , Micev Marjan , Popovic Bojana , Ognjanovic Sanja , Tatjana Isailovic , Ilic Dusan , Bogavac Tamara , Opalic Milica , Valentina Elezovic-Kovacevic , Macut Djuro

IntroductionMerkel cell carcinoma-MCC) is a rare, aggressive, neuroendocrine skin tumor with a poor prognosis. Chemotherapy (CT) and/or local/locoregional radiotherapy (LRRT) are first-line MCC therapies, but disseminated/locally advanced MCCs often become resistant to this treatment. The use of programmed cell death receptor1/programmed cell death ligand 1 (PD-1/PD-L1) monoclonal antibodies is a new type of therapy for MCC. While PD-1 monoclonal antibod...