Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep615 | Endocrine-Related Cancer | ECE2022

Frequency of CYP1B1 gene polymorphism in obese and non-obese women with hormone-dependent endometrial cancer

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Aim: There is a significant link between the increased activity of estrogen and its metabolites in endometrial carcinogenesis. Polymorphisms of the gene involved in metabolism of estrogen can modulate risk for the development of endometrial cancer. CYP1B1 plays an important role in estrogen metabolism. In our study, the frequency of three CYP1B1 gene polymorphisms (4326 C> G, 4390 A> G and 355 G> T) were studied in obese and non-obese women with endometrio...

ea0090ep618 | Endocrine-related Cancer | ECE2023

Merkel cell carcinoma, experience of a single center

Ilic Dusan , Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , P. Macut Djuro

Introduction: Merkel cell carcinoma is a rare and aggressive neuroendocrine skin cancer. It is characterized by a high rate of local recurrence after surgical resection as well as the occurrence of distant metastases. It mostly occurs in the elderly and the exact etiology is unknown. The most significant risk factors for its occurrence are exposure to ultraviolet light and the oncogenic effect of the Merkel cell polyoma virus.Aim: Demographic and clinica...

ea0099ep38 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Relations of C-reactive protein to post-glucose load glucose in patients with prediabetes and coronary artery disease

Tankovic Valentina , Stankovic Sinisa , Popovic Pejicic Snjezana , Malesevic Gabrijela , Markovic Aleksandra , P. Macut Djuro

Introduction: The association between CRP and prediabetes has not been sufficiently investigated. The aim of the study was to determine the association of prediabetes with subclinical inflammation, as well as to examine the correlation of sensitive CRP (hsCRP) with fasting glycemia and 2 h glycemia during exercise during the OGTT test.Methods: The study included 106 patients with angiographically diagnosed coronary artery disease, who, based on the oral ...

ea0090ep582 | Endocrine-related Cancer | ECE2023

Clinical characteristics and survival of patients with functional lung neuroendocrine tumors

Popovic Bojana , Ognjanovic Sanja , Ilic Dusan , Elezovic Kovacevic Valentina , Opalic Milica , Radic Lena , Micev Marijan , P. Macut Djuro

Aim: Functional neuroendocrine tumors (NETs) represent a specific diagnostic and therapeutic challenge. Hormonal clinical syndrome can severely complicate clinical picture and affect treatment. Functional pancreatic NETs have been extensively studied. Our aim was to analyze functional lung NETs in terms of clinical characteristics and survival.Materials and methods: We retrospectively analyzed data from 230 patients with lung NETs treated at our departme...

ea0090ep689 | Pituitary and Neuroendocrinology | ECE2023

Clinical experience of single tertiary center in managing patients with paraganglioma

Kovacevic Valentina Elezovic , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Ilic Bojana , Opalic Milica , Radic Lena , P. Macut Djuro

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic/parasympathetic neural ganglia, respectively. We retrospectively analyzed 82 patients (43 female and 38 males) predominantly with PGLs who were hospitalized between January 2002 and December 2022. Twenty one patients were lost to follow up. The median age at diagnosis was 47 years (11–75) and the mean tumor size was ...

ea0090ep913 | Reproductive and Developmental Endocrinology | ECE2023

Association between circulating adiponectin levels and androgen excess in polycystic ovarian syndrome

Soldat Stankovic Valentina , Stankovic Sinisa , Popovic Pejicic Snjezana , Dojcinovic Tamara , Malinovic Pancic Jelena , Malesevic Gabrijela , P. Macut Djuro

Background: Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to androgen excess in these women. Therefore, the aim of the present study was to examine the association of adiponectin levels and androgens in women with PCOS.Methods: A total of 60 women with PCOS who met the 2003 Rotterdam ...

ea0099p145 | Reproductive and Developmental Endocrinology | ECE2024

European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS special interest group’s 2023 questionnaire

Livadas Sarantis , Yildiz Bulent , Mastorakos George , Gambineri Alessandra , Pignatelli Duarte , Giorgino Francesco , Andersen Marianne , Obermayer-Pietsch Barbara , P. Macut Djuro

Background: Although polycystic ovary syndrome (PCOS) constitutes a common endocrinopathy, there are several issues which confuse clinicians during everyday practice.Objective: To define the current status of knowledge of the full spectrum of PCOS among European endocrinologists.Methods: A detailed questionnaire comprising 41 items covering various aspects of diagnosis and management of women with PCOS was shared via web among memb...

ea0099ep419 | Adrenal and Cardiovascular Endocrinology | ECE2024

Correlation of hypothalamic-pituitary-adrenal axis parameters with the size of adrenal incidentaloma

Ognjanovic Sanja , Popovic Bojana , Elezovic Kovacevic Valentina , Ilic Dusan , Opalic Palibrk Milica , Radic Lena , Krstic Katarina , P. Macut Djuro

Introduction: The majority of adrenocortical incidentalomas (AIs) are nonfunctional adenomas. Some of them demonstrate an autonomous cortisol secretion (ACS), a pathologic condition defined as biochemical evidence of hypercortisolism without typical signs or symptoms of Cushing’s syndrome.Subjects and methods: In this cross-sectional study, we evaluated 152 consecutive patients, aged 58.3 years (range, 25-84 years) of whom 105 (69.1%) with unilatera...

ea0099ep151 | Reproductive and Developmental Endocrinology | ECE2024

Assessment of non-invasive NAFDL indices in patients with PCOS

Elezovic Kovacevic Valentina , Ognjanovic Sanja , Popovic Bojana , Ilic Dusan , Opalic Palibrk Milica , Radic Lena , Krstic Katarina , Bjekic Macut Jelica , Vojnovic Milutinovic Danijela , Stanojlović Olivera , P. Macut Djuro

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in reproductive-age women. This highly complex reproductive metabolic disorder is independently associated with high prevalence of non-alcoholic fatty liver disease (NAFLD). While the gold standard of NAFLD diagnosis is liver biopsy or MRI, it is costly and hard to perform in large population. Recently, simple and convenient markers, such as liver fat score (LFS), fatty liver inde...