Searchable abstracts of presentations at key conferences in endocrinology

ea0090p40 | Calcium and Bone | ECE2023

Polymorphisms in genes related to iron metabolism and DNA methylation and their interaction with estradiol in susceptibility to osteoporosis in postmenopausal women

Aguiar Laura , Ferreira Joana , Paula Barbosa Ana , Rui Mascarenhas Mario , Faustino Paula , Inacio Angela , Bicho Manuel

Introduction: Osteoporosis is a multifactorial disease characterized by reduced bone mass and increased risk of fragility fractures. Menopause predisposes women to osteoporosis due to declining estrogen levels. Iron is known to play a relevant role in the development of osteoporosis since iron suppresses osteoblast formation and may also stimulate osteoclast resorption of bone. Also, homocysteine is a known risk factor for osteoporotic fractures and is related to DNA methylati...

ea0056p201 | Bone ' Osteoporosis | ECE2018

May polymorphisms of DHFR, CBS and MTHFR genes modulate metabolic and bone remodeling parameters associated with reduced bone mineral density?

Freitas Joana , Carvalho Carla , Ribeiro Carolina , Sarmento David , Paula Barbosa Ana , Rui Mascarenhas Mario , Bicho Manuel

Objectives: To study the association of functional polymorphisms at DHFR, CBS and MTHFR genes with bone mineral density (BMD) and metabolic parameters of bone remodeling.Materials and methods: BMD (g/cm2) was measured by DEXA in 391 subjects: 174 with normal BMD (137F 37M; age=48.79±12.99 years; BMI=29.61±5.22 kg/m2), 62 with osteopenia (48F 14M; age=56.06±12.96 years; BMI=27.64±4.94 kg/m2) and 154 with osteoporosis (119F, 35M; age=64...

ea0073aep876 | Late Breaking | ECE2021

Influence of bitter taste gene TAS2R38 on endocrinometabolic and anthropometric parameters in a sample with thyroid disease

Mendes Costa Marta , Carolina Santos Ana , Ferreira Joana , Mário Rui Mascarenhas , Bicho Manuel , Paula Barbosa Ana , Alda Pereira da Silva

Background and objectivesTAS2R38 is a bitter taste gene that can influence food consumption depending on its single nucleotide polymorphisms (SNPs) leading to aminoacid substitutions in the receptor protein P49A (proline/alanine), A262V (alanine/valine) e V296I (valine/isoleucine). Subjects with at least one PAV (proline-alanine-valine) copy are bitter tasters, while AVI homozygotes are non-tasters. Other variants have intermediate bitter tasting: AAV&#6...