Searchable abstracts of presentations at key conferences in endocrinology

ea0081s24.1 | Diabetes remission: From dream to clinical goal | ECE2022

Type 1 diabetes remission: who, how and when

Pozzilli Paolo

Type 1 diabetes (T1D) is a chronic disease of childhood that also presents in adults, resulting from the destruction of insulin-producing β-cells by auto-reactive T cells that have escaped central and peripheral immune tolerance. It is now well established that T1D is characterised by a wide heterogeneity especially in terms of age at onset, representing a major barrier for both pathogenesis and translational efforts aimed to develop novel therapeutics approach. This conc...

ea0081p75 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes technology and quality of life: glucose control and beyond

Irina Briganti Silvia , Maggi Daria , Strollo Rocky , Kyanvash Shadi , Lanza Oreste , Pozzilli Paolo , Manfrini Silvia

Background: Technological advances in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) should aim to improve glucose control and quality of life in patients diagnosed type 1 diabetes (T1D).Aim: The aim of our study was to compare different CGM and CSII devices on these targets.Methods: Sixty-nine T1D patients (mean age 39±12; 31 males) were recruited. 36 were on multiple daily insulin inj...

ea0081p321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of a novel-app based strategy for carbohydrate counting on glucose control in type 1 diabetes

Briganti Silvia Irina , Strollo Rocky , Maggi Daria , Kyanvash Shadi , Lanza Oreste , Manfrini Silvia , Pozzilli Paolo

Background: carbohydrate counting is often performed inaccurately by patients with type 1 diabetes (T1D). We hypothesized that mobile App ‘Dietrometro’, that estimates CHO content of food figures, would ameliorate glucose control.Aim: To study the effect of ‘Dietometro’ on glucose control.Methods: 54 T1D subjects (aged 18-60 years, 26 males), on multiple daily injections (n=23) or continuous subcutaneou...

ea0081p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Roux-en-Y gastric bypass and vertical sleeve gastrectomy showed similar efficacy in achieving cardiometabolic composite target in subject with type 2 diabetes undergoing bariatric surgery

Monte Lavinia , Tuccinardi Dario , Rossini Giovanni , Watanabe Mikiko , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: The American Diabetes Association (ADA) produced a triple composite outcome that summarizes the therapeutic targets of the three most prevalent complications of obesity: type 2 diabetes (T2D), hypertension and dyslipidemia (HbA1c <7.0%; LDL cholesterol<100 mg/dl and systolic blood pressure <130 mmHg). The present study primarily investigates the difference between VSG and RYGB in achieving the composite target one year after the surgery. The secondary...

ea0081ep191 | Calcium and Bone | ECE2022

Primary hyperparathyroidism in the setting of previous roux-en-Y gastric bypass: a case report

Monte Lavinia , Tuccinardi Dario , Strollo Rocky , Briganti Silvia , Rausa Donatella , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: Primary hyperparathyroidism (PHPT) after roux-en-Y gastric bypass (RYGB) is poorly described. The diagnosis can be difficult as secondary hyperparathyroidism(SHPT) commonly occurs in patients after RYGB due to calcium hypoabsorption and vitamin D deficiency.Observation: We present the case of a 50-year-old female with a history of normocalcemic hyperparathyroidism and nephrolithiasis. In 2005 the patient had undergone RYGB. During the first...

ea0020p466 | Obesity and Metabolism | ECE2009

Glucose RapidSpray™ as adjuvant in diet restriction programmes

Khazrai Yeganeh Manon , Cacciapaglia Fabio , Altomare Maria , Leotta Sergio , Pozzilli Paolo

Overweight and obese subjects often suffer from hypoglycaemic symptoms due to hyperinsulinemia. This increases subjects’ need to eat excessive amount of food enriched in sugar causing rebound hyperglycaemia which in turn stimulates endogenous insulin release perpetuating a vicious circle that limits weight loss under diet restriction programme. Two previous studies showed that administration of Glucose RapidSpray™ (GRS) in quantity of ~ 0.5 g increases blood glucose ...

ea0016p197 | Diabetes and cardiovascular diseases | ECE2008

Circulating Reg1-α plasma levels: potential marker of beta cell regeneration?

Guglielmi Chiara , Battistoni Fabrizio , Valente Luciana , Astorri Elisa , Pitocco Dario , Pozzilli Paolo

Reg and Reg-related genes are members of a multifunctional family. Under physiological conditions Reg protein is not expressed in pancreatic beta cells, although the Reg protein receptor is expressed. When islets are damaged, the expression of Reg gene is increased in the islets of Langherans. In type 1 diabetes (T1D), insulin secretion may be still detectable in some subjects with long-standing disease indicating the existence of a small population of surviving beta cells or ...

ea0016p258 | Diabetes and cardiovascular diseases | ECE2008

Rapid glucose spray™ for the management of hypoglycaemia in children with type 1 diabetes

Pronina Ekaterina , Petraikina Helen , Antsiferov Michail , Duchareva Olga , Guglielmi Chiara , Merola Manon Yeganeh , Pozzilli Paolo

Hypoglycaemia continues to be a difficult condition to treat especially in infants and young children who cannot administer treatment themselves. Administering the correct dose of sugar is difficult for several reasons: the child may not want to intake food and it may be difficult to force the child to chew or swallow, it is difficult to identify the quantity of sugar necessary to reach optimal glucose levels. If too much sugar is administered, high levels of blood glucose may...

ea0081ep588 | Endocrine-Related Cancer | ECE2022

Severe refractory nonislet cell tumor hypoglycemia and paraneoplastic hypercalcemia in a patient with pancreatic adenocarcinoma with neuroendocrine differentiation: a case report.

Rossini Giovanni , Tommaso Alfonso Maria Di , Rausa Donatella , Palermo Andrea , Tuccinardi Dario , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Nonislet cell tumor hypoglycemia (NICTH) is a rare complication of malignancy characterized by overproduction of incompletely processed IGF-2 and subsequent stimulation of insulin receptors and increased glucose utilization. We report a patient with pancreatic adenocarcinoma with neuroendocrine differentiation who presented with NICTH and paraneoplastic hypercalcemia. A 51 year-old male was admitted to the ER for altered mental status and confusion. His blood glucose was 27 mg...

ea0073aep627 | Thyroid | ECE2021

Laser ablation versus radiofrequency ablation for benign non-functioning thyroid nodules: twelve-month results of a randomized, parallel-arm, open-label trial

Cesareo Roberto , Manfrini Silvia , Pasqualini Valerio , Ambrogi Cesare , Sanson Gianfranco , Gallo Andrea , Pozzilli Paolo , Pedone Claudio , Crescenzi Anna , Palermo Andrea

BackgroundRadiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign non-functioning thyroid nodules (BNTNs). We compared the efficacy and safety of both thermal ablation treatments at the 12-month follow-up in patients with solid or predominantly solid BNTN.MethodsThis 12-month, single-use, randomized open-label parallel trial c...