Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep670 | Pituitary and Neuroendocrinology | ECE2023

Carney complex as a rare reason of acromegaly in adulthood

Perepelova Margarita , Przhiyalkovskaya Elena , Dzeranova Larisa , Pigarova Ekaterina , Kolodkina Anna

Carney complex is a rare hereditary syndrome with an autosomal dominant inheritance pattern that manifests itself with a set of specific symptoms. Case presentation. 32-year-old woman was admitted to the endocrinological hospital with an active stage of acromegaly. From the anamnesis it is known that at the age of 11, the height was 172 cm. The diagnosis of acromegaly was established at the age of 28 years: IGF-1 673.8 ng/ml (78–311), pituitary gland with para(d)-sellar s...

ea0063p1117 | Pituitary and Neuroendocrinology 3 | ECE2019

Epidemiology of acromegaly in Russian Federation: evaluation of National registry-based data

Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Belaya Zhanna , Rozhinskaya Liudmila

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

ea0081ep644 | Pituitary and Neuroendocrinology | ECE2022

Dynamics copeptin and apelin in patients before and after transnasal adenomectomy and their relationship with the development of postoperative hyponatremia

Fargieva Khava , Katamadze Nino , Dzeranova Larisa , Pigarova Ekaterina , Przhiyalkovskaya Elena , Griroriev Andrey , Mokrysheva Natalia

Introduction: Transnasal adenomectomy is the main treatment for various pituitary adenomas. The hypothalamic-pituitary region is the site of synthesis and secretion of several hormones that have a direct effect on sodium-water metabolism, which leads to its frequent violation with the development of central diabetes insipidus and severe transient hyponatremia, the latter of which is the second most important cause of rehospitalization in the postoperative period. Currently, th...

ea0081ep724 | Pituitary and Neuroendocrinology | ECE2022

Short-term and long-term surgical remission of acromegaly in a tertiary medical center

Lutsenko Alexander , Belaya Zhanna , Przhiyalkovskaya Elena , Rozhinskaya Liudmila , Grigoriev Andrey , Azizyan Vilen , Melnichenko Galina

Background: Surgical outcomes in patients with acromegaly are highly dependent on a surgeon’s level of expertise, as the majority of patients present with macroadenomas at diagnosis.Aim: To assess remission rates in patients with acromegaly admitted to a tertiary medical center.Materials and methods: We included patients admitted to the neuroendocrinology and bone disease department with no previous radiation therapy or curren...

ea0081ep785 | Pituitary and Neuroendocrinology | ECE2022

Clinical case of syndrome of inappropriate secretion of antidiuretic hormone (SIADH) with uncertain localization

Pigarova Ekaterina , Dzeranova Larisa , Katamadze Nino , Fargieva Khava , Malysheva Natalya , Nikankina Larisa , Przhiyalkovskaya Elena

Introduction: The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is characterized by hypotonic and euvolemic hyponatremia along with urinary hyperosmolarity, resulting from antidiuretic hormone (ADH) release in the absence of adequate stimuli.Case report: A 59-year-old woman, presented with complaints of constant thirst, general weakness, memory loss, episodes accompanied by headaches, leg cramps, increased blood pressure. From the a...

ea0090ep680 | Pituitary and Neuroendocrinology | ECE2023

Clinical features and long-term follow-up of patients with Nelson syndrome: a case series presentation

Lutsenko Alexander , Trukhina Diana , Belaya Zhanna , Przhiyalkovskaya Elena , Dzeranova Larisa , Pigarova Ekaterina , Rozhinskaya Liudmila

Background: Nelson syndrome is a rare complication of Cushing disease (CD), which occurs either in patients with very aggressive CD or as a result of misdiagnosis. Clinical characterization of patients with Nelson syndrome could provide important insights in management of the disorder.Methods: We analyzed medical records of patients with CD between 2015 and 2021 to identify those who developed Nelson syndrome.Results: Nine patients...

ea0090ep696 | Pituitary and Neuroendocrinology | ECE2023

Clinical case of reverse hearing loss in a patient with acromegaly and pituitary macroadenoma

Perepelova Margarita , Dzeranova Larisa , Shutova Aleksandra , Lepeshkina Lyudmila , Pigarova Ekaterina , Azizyan Vilen , Akopyan Pavel , Przhiyalkovskaya Elena

Background: Acromegaly is an orphan neuroendocrine disease characterized by a variety of complications. Due to slow symptom progression acromegalic patients often are involved in growth hormone complications correction for a long time instead of search for main cause of these multiple disorders. A view on conductive hearing loss in acromegaly in literature is contradictory. The low incidence of hearing in acromegaly, compared with other complications, is presumably due to the ...

ea0090ep726 | Pituitary and Neuroendocrinology | ECE2023

Joint disease in patients with acromegaly

Perepelova Margarita , Przhiyalkovskaya Elena , Tarbaeva Natalya , Dzeranova Larisa , Pigarova Ekaterina , Kovalevich Liliya

Background: Acromegaly is a neuroendocrine disease that occurs with slowly progressive symptoms, which leads to delayed diagnosis and the development of complications. Arthropathy is one of such complications, which is accompanied by severe pain and significantly worsens the quality of life. The main attention of researchers is devoted to the pathology of the hip, knee and hand joints. At the same time, the study of the shoulder, acromioclavicular, costovertebral joints in acr...

ea0049ep1028 | Pituitary - Clinical | ECE2017

Russian hypothalamic and pituitary tumors registry (OGGO) data analysis: acromegaly

Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Belaya Zhanna , Rozhinskaya Liudmila , Stanoevich Irina

Objective: To analyze registry data on patients with acromegaly.Materials and methods: Russian hypothalamic and pituitary tumors registry database (on-line platform), which contains data on 3719 patients with acromegaly.Results: According to the database, highest prevalence of acromegaly per 100 000 inhabitants is registered in: Penza region (7.3), Kirov region (7.3), Krasnoyarsk region (6.2). Most common clinical presentations in ...

ea0037ep689 | Pituitary: basic and neuroendocrinology | ECE2015

Gene panel study for familial pituitary adenoma

Borodich Tatiana , Pigarova Ekaterina , Przhiyalkovskaya Elena , Dzeranova Larisa , Rozhinskaya Liudmila , Vasilyev Evgeny , Tiulpakov Anatoly , Dedov Ivan

Introduction: Several genetic syndromes are associated with familial pituitary adenomas. The penetrance of clinical manifestations of these syndromes is not ubiquitous and this might be the reason for the lack of detection of genetic mutations when only one or few genes are studied.Aim: Clinical characterisation and molecular genetic study of a panel with ten genes involved in formation of pituitary adenomas in familial setting.Mat...