Searchable abstracts of presentations at key conferences in endocrinology

ea0026p683 | Diabetes therapy | ECE2011

Monitoring thyroid function in diabetic patients on treatment with glucagon-like peptide 1 analog

Danciulescu R , Musat M , Rosca R , Cristescu V , Poiana C

Background and aims: Incretin mimetics are a new class of pharmacological agents with antihyperglycemic actions that mimic the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1. The thyroid gland exhibit a strong GLP-1 receptor expression in rodents but only low receptor levels in humans. GLP-1 receptors activation stimulates calcitonin secretion and promotes the development of C cell hyperplasia and medullary thyroid cancer in rodents....

ea0026p172 | Neuroendocrinology | ECE2011

Age related distribution of the endothelial nitric oxide synthase gene G894T polymorphism: relationship with metabolic-endocrine and cognitive features

Ianas O , Manda D , Heltianu C , Vladoiu S , Popa O , Rosca R , Oros S , Covic M , Joja O

Background: Genetic variants of the endothelial nitric oxide synthase (eNOS) gene have been reported to be associated with vascular disease. We hypothesized that G894T polymorphism might trigger many of the endocrine-metabolic cognitive changes related to aging.Study design: One hundred and eighty subjects aged 55–80+ years with moderately cognitive impairment (MCI) (MMSE<28) (lot 1), 140 age-matched subjects without cognitive impairment (MMSE&#...

ea0026p518 | Bone/calcium/Vitamin D | ECE2011

Bone turnover markers and the metabolic syndrome

Oros S E , Ianas O , Manda D , Rosca R I , Popa O M , Vladoiu S , Dumitrache C

Obesity was considered to be a protective condition against osteoporosis. New studies suggest that visceral obesity is associated with low BMD and a higher risk for fracture. Patients with diabetes mellitus, although they do not have a lower BMD, have a higher fracture risk, probably due to the lower bone turn over.Aim: The aim of the study was to evaluate bone metabolism in connection with hormonal profile in postmenopausal women with metabolic syndrome...

ea0026p566 | Cardiovascular endocrinology and lipid metabolism | ECE2011

Apolipoprotein A1 and B100 and hormones in postmenopausal women

Oros S E , Ianas O , Manda D , Rosca R I , Vladoiu N S , Popa O M , Giurcaneanu M , Dumitrache C

Menopause is a physiological condition associated with an important change in the hormonal status, an adverse lipid profile and cardiovascular risk. Apolipoproteins are proteins that bind to lipids to transport them. Apolipoprotein intestine synthesis is regulated principally by the fat content of the diet, while in the liver by dietary composition, hormones, alcohol intake and lipid lowering drugs. Are they changed due to aging? Do they interfere in the hormonal changes?<...

ea0029p131 | Bone &amp; Osteoporosis | ICEECE2012

Vitamin D and estrogen receptors’ polymorphisms in postmenopausal women

Oros S. , Ianas O. , Vladoiu S. , Giurcaneanu M. , Neacsu E. , Voicu G. , Stoiceanu M. , Rosca R. , Neamtu C. , Badiu C. , Dumitrache C.

Osteoporosis is a polygenic disease. The intensive search for genetic markers has led to the identification of several genetic polymorphisms, associated with the decrease of bone tissue and therefore a higher risk of osteoporosis.The study aimed to evaluate estrogen receptor alpha (ESR1) and vitamin D receptor (VDR) polymorphisms in postmenopausal women with or without osteoporosis and their correlations with bone markers and adipocytokines.<p class=...