Searchable abstracts of presentations at key conferences in endocrinology

ea0046p5 | (1) | UKINETS2016

Incidence and characteristics of Ileo-colonic neuroendocrine tumours identified in the UK bowel cancer screening programme

Basuroy Ron , Srirajaskanthan Rajaventhan , O'Donnell Katie , Brooks Corrine , Ramage John

Background: Colorectal cancer is the third most common cancer in the UK this had led to development of the bowel cancer screening programmes (BCSPs). It is known that ileo-colonic NETs are increasing in incidence in part thought to be related to increased endoscopy. There are few epidemiological data on rectal or ileal NETs diagnosed in BCSPs. This study aims to identify the number of NETs diagnosed through the UK BCSP.Methods: UK bowel cancer colonoscop...

ea0046p10 | (1) | UKINETS2016

Biomarkers for carcinoid heart disease

Basuroy Ron , Ramage John , Sherwood Roy , Srirajaskanthan Rajaventhan

Introduction: Carcinoid heart disease (CHD) develops in patients with small bowel NETs with carcinoid syndrome. Currently NT-proBNP (NTP) is suggested as the best current biomarker to screen for CHD and monitor heart failure. A number of other markers have been investigated for heart failure, however, none of these have been explored in NET patients with CHD or carcinoid syndrome. Galectin-3 (GAL3) promotes fibroblast proliferation and correlates with worse outcomes in heart f...

ea0080p7 | Abstracts | UKINETS2021

Sex specific differences in overall survival in patients with pulmonary neuroendocrine neoplasms (NENs) in a large United Kingdom (UK) tertiary centre

Clement Dominique , Brown Sarah , Mulholland Nicola , Sarker Debashis , Giwa Mojisola , Koundouraki Antonia , Ramage John , Srirajaskanthan Raj

Introduction: Pulmonary NENs account for around 2% of all pulmonary malignancy. They are classified histologically into 4 types typical and atypical carcinoids which are generally well differentiated and large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC) which are poorly differentiated. Within the literature there are several reports regarding overall survival on small mainly surgical cohorts, but data for the UK population are lacking. Only a few...

ea0087oc1 | Oral Communications | UKINETS2022

Urine 5-HIAA levels and quality-of-life in neuroendocrine neoplasia. Is there an association?

Chaudhry Rayhan , White Benjamin , Kandiah Chandrakumaran , Vincent Royce , Srirajaskanthan Rajaventhan , Clement Dominique , Ramage John

Introduction: Patients with neuroendocrine neoplasia (NEN) may experience psychological distress related to secretory effects of the tumour. 5-hydroxyindoleacetic acid (5-HIAA) is a metabolite of serotonin, the most important secretory product in carcinoid syndrome. This study aims to determine if urine 5-HIAA levels correlate with health-related quality of life (HRQoL) in patients with NEN.Methods: A retrospective single-centre cohort study was conducte...

ea0068oc3 | Abstracts | UKINETS2019

Incidence and prevalence of neuroendocrine neoplasms reported in England from 2015 to 2017

White Benjamin E , Bouvier Catherine , Genus Tracey , Rous Brian , Srirajaskanthan Rajaventhan , Chandrakumaran Kandiah , Ramage John K

Introduction: Previously published UK Cancer Registry data showed incidence of Neuroendocrine Neoplasms rising between 2001 and 2015. This was higher than had been thought (Genus et al.). We report more recent data with more accurate coding (ICD-O-3).Aim: To analyse National Cancer Registration and Analysis Service (NCRAS) data on Neuroendocrine Neoplasias (NENs) in England including years 2015–2017.Methods: Public He...

ea0068p19 | Abstracts | UKINETS2019

Endoscopic management and outcomes of gastro-duodenal neuroendocrine tumours

Victor Alexandra , Pizanias Michail , Gulati Shraddha , Gunasingham Nishmi , Ramage John Keith , Haji Amyn , Srirajaskanthan Raj

Background: Gastric and duodenal neuroendocrine tumours are increasing in incidence. ENETS guidelines suggest endoscopic resection of type 1 gastric NENs over 10 mm and consider endoscopic resection for duodenal NENs. However, the endoscopic techniques are not clearly mandated. There, is evidence to suggest endoscopic mucosal dissection has higher incidence of R0 resections compared with polypectomy or EMR alone. We have reviewed our data of endoscopic resection of gastro-duod...

ea0072p6 | (1) | UKINETS2020

Metachronous neuroendocrine neoplasms in England 2013–2015

White Benjamin E , Genus Tracey , Bouvier Catherine , Ramage John K , Srirajaskanthan Rajaventhan

Introduction: The aetiology of NENs vary; some are sporadic, others familial. An association between index NENs of the mid gut (ileum and colon) with subsequent colorectal primaries has been reported.Aim: We determined to evaluate the relationship between the diagnosis of an index primary malignancy and subsequent diagnosis of NEN.Methods: A population-based retrospective cohort study was under taken for persons with NEN diagnosis ...

ea0072p7 | (1) | UKINETS2020

Carcinoid heart surgery: Review of outcomes from a single large centre

Maclean Rory , Cope Jack , Hota Shweta , Mulholland Nicola , Ramage John , Wendler Olaf , Srirajaskanthan Raj

Introduction: Up to half of patients with carcinoid syndrome develop carcinoid heart disease; this is thought to be mediated by serotonin from disordered tryptophan metabolism. Valve degeneration can lead to right heart failure which drives morbidity and mortality in this patient population. Surgical replacement of affected valves is an effective therapy. Peptide receptor radiotargeted therapy (PRRT) has demonstrated better progression-free survival compared to high dose sando...

ea0096p26 | Section | UKINETS2023

Case report: a rectal neuroendocrine tumour with dynamic grade and clinical behaviour

Evan Theodore , Sarker Debashis , Mencel Justin , Srirajaskanthan Raj , Clement Dominique , Ramage John , Brown Sarah , Dolly Saoirse

Introduction: Neuroendocrine tumours (NETs) may change grade and clinical behaviour substantially over time, requiring shifts in management strategy.Case Presentation: A 53-year-old lady presented with abdominal bloating and diarrhoea. Diagnostic MRCP and CT-CAP confirmed metastatic cancer, with bilobar liver metastases and a sclerotic lesion in the right ilium. Her disease was 68Ga-DOTATATE-avid. Rectal biopsy confirmed...

ea0080OC1 | Oral Communications | UKINETS2021

Incidence, prevalence of survival of neuroendocrine neoplasia in England 1995–2018

White Benjamin E , Chandrakumaran Kandiah , Wong Kwok , Rous Brian , Bouvier Catherine , Van Hemelrijck Mieke , Srirajaskanthan Rajaventhan , Ramage John K

Introduction: Incidence of neuroendocrine neoplasia (NEN) is rising worldwide. The National Cancer Registry and Analysis Service allows accurate study of NEN in England. Aim: Calculate incidence and prevalence of NEN in England from 1995-2018. Calculate site-specific survival with multivariate analysis. Method: A population-based retrospective cohort study was performed. Data requested from NCRAS were reviewed by a steering group r...