Endocrine Abstracts

Introduction: Insulinomas are the most frequent cause of hypoglycemia and the most common functional endocrine pancreatic tumors. Whipple triad is often present and should alert to the diagnosis.Case report: A 36-year-old male was admitted in the emergency room with loss of consciousness, diaphoresis and blurred vision, and hypoglycemia (50 mg/dl). The patient recalled recurrent symptoms of diaphoresis, tremors and palpitations, sometimes with loss of co...

Introduction: Thyroid storm is a rare medical emergency with high mortality, which usually results from acute exacerbation of hyperthyroidism. Amiodarone is a highly used class III antiarrhythmic drug and amiodarone-induced thyrotoxicosis is an infrequent effect of this medication, whose treatment may be difficult.Case study: A 20-year old male with congenital cardiomyopathy (Fallot tetralogy and Ebstein anomaly), chronically medicated with amiodarone 20...

Introduction: Radioiodine treatment (RAIT) is an effective definitive treatment for Graves’ Disease (GD) and Toxic Nodular Goiter (TNG). The aim of this study was to analyze demographic and clinical factors affecting the outcome of RAIT in patients with hyperthyroidism.Methods: Retrospective review of patients treated with RAIT for hyperthyroidism. A fixed dose of 10 mCi was administered to patients with GD and 15 mCi to patients with TNG. Treatment...

Objectives: Assess the efficacy and safety of ultrasound-guided percutaneous ethanol injection (PEI) for treating benign cystic or predominantly cystic-thyroid nodules (TN).Methods: Retrospective analysis of all euthyroid patients treated with PEI for purely (>90% of cystic component) or predominantly cystic (50%-90% of cystic component) TN between January 2018 to February 2023. Efficacy was defined as 50% or greater reduction in pretreatment volume ...

Objectives: To evaluate the relationship between free T3 (FT3) levels with symptoms suggestive of thyroid dysfunction, and quality of life (QoL) outcomes, in patients with compensated primary hypothyroidism (PH).Methods: Cross-sectional study encompassing Portuguese levothyroxine(LT4)-treated patients for PH who presented Thyroid-stimulating hormone (TSH) and free T4 (FT4) within the normal range. Pregnant women, patients with central hypothyroidism and/...

Introduction: The deleterious effects of obesity on spontaneous reproduction are well recognized, although the literature on obesity and assisted reproductive technology outcome remains heterogeneous and inconsistent.Objective: To estimate the effect of BMI on ovarian stimulation response and live birth in women underwent in vitro fertilization (IVF).Methods: Retrospective observational study that included women submitted ...

Introduction: Diabetic ketoacidosis (DKA) is characterized by the triad – ketonemia, metabolic acidosis and hyperglycemia. It is typically associated with type 1 Diabetes Mellitus (T1D) and the most common culprits are infections and poor therapeutic compliance.Clinical Case DescriptionThe present case deals with a 25–year–old female patient, with T1D diagnosed in 2008, without microvascular or macrovascular compl...

Introduction: Adrenal insufficiency (AI) is a rare and potentially life-threatening disease. The most common causes are primary adrenal insufficiency (Addison’s Disease), due to an adrenocortical disease, and secondary insufficiency, due to disorders of the pituitary gland. Chronic glucocorticoid replacement is vital and patients should be educated about how to act in acute stress situations, in order to avoid adrenal crisis. Taking this into account, we organized educati...

Introduction: Graves’ disease (GD) hyperthyroidism is caused by autoantibodies against TSH receptor (TRAb). Three varieties of TRAb are now recognized: stimulating (TSI), blocking and neutral antibodies. Current TRAb immunoassays detect and quantify serum immunoglobulins that interact with the TSH receptor but without discriminating their function. An automated immunoassay for the detection and quantification of TSI is available.Objective: Our study...

Introduction: Insulin resistance, often implicated in the pathophysiology of Type 2 Diabetes Mellitus, can also occur in patients with Type 1 Diabetes Mellitus (T1DM), giving rise to a distinct phenotype that some authors describe as Double Diabetes - a population with a higher risk of developing chronic complications. The estimated glucose disposal rate (eGDR) is a validated marker of insulin resistance in Type 1 Diabetes (T1DM), based on data obtained from the hyperinsulinem...