Endocrine Abstracts

Background: The association between diabetes and dementia has been well documented (1, 2, 3) and with Australia’s aging population, the already significant disease burden of both pathologies will inevitably progress over time. Despite both being progressive pathologies which escalate over time, there have not been any studies pertaining to degree of glycaemic control and the extent to which this relates to prevalence of dementia.Aims: To determine a...

BackgroundThe reported HMBS mutations of acute intermittent porphyria(AIP) have been increasing gradually in China. We aim to explore its mutation characteristic in China and improve the understanding of its molecular heterogeneity.Material/methodsWe searched the literature about Chinese AIP patients with HMBS mutation in the PubMed, CNKI, Wanfang and CQVIP database, and 3 AIP patients with HMBS mutation in o...

Purpose: To investigate the effects of Tribulus terrestris (TT) on immune function in over-trained rats and explore the mechanisms – the role of glucocorticoid (GC) and glucocorticoid receptor (GR).Methods: Thirty male SD rats were randomly divided into control group, over-trained group and over-trained+TT group. The last two groups were trained on a motor-driven treadmill with a progressively increased load for 6 weeks. The over-trained+TT...

Context: Transcriptomic based characterization of signaling pathways in the adrenals of different subtypes of Cushing’s syndrome.Patients: For preliminary NGS analyses, a total of 27 adrenal samples were used. The cohort consisted of the following patient groups: Cortisol producing adenoma (CPA, n=9), primary bilateral macronodular adrenal hyperplasia (PBMAH, n=10). The adjacent normal adrenal tissue from pheochromocytoma patients ...

Personalized medicine is a crucial part of modern medicine. As a result, other therapeutic options apart from levothyroxine are considered when treating hypothyroidism. Desiccated thyroid pharmaceuticals, that in addition to thyroxine (T4), contain triiodothyronine (T3), are one of them. ETA recognized the rapid use of desiccated thyroid pharmaceuticals and described specific guidelines for its utilization. The biggest problem of their use is unresolved issues of content that ...

Introduction: Transcriptional regulation of gene expression by miRNAs is critical for the fine-tuning of adrenal stress response. However, its role in hypercortisolism has not been explored well. The study addresses this gap using adrenal samples of 3 patient groups from the German Cushing’s registry: Cortisol-Producing-Adenoma (CPA), Primary Bilateral Adrenal Hyperplasia (PBMAH) and controls (adrenal samples of patients with pheochromocytoma).Metho...

Introduction: Transcriptional regulation of gene expression by miRNAs is critical for the fine-tuning of stress response. However, its role in hypercortisolism has not been explored well. After exploring circulating miRNAs in Cushing’ Syndrome (CS) as biomarkers our aim was to investigate their origin and their role in adrenal tissue.Methods: Next generation sequencing (NGS) based miRNA profiling was performed in adrenal samples from patients of Ger...

Objective: Distant metastases from papillary thyroid carcinoma (PTC) are relatively rare and may be associated with a poor prognosis. Herein, we describe a case report with adrenal and lung metastasis of follicular variant of PTC in the context of the review of the literature.Case Report: A 52-year-old male presented with complaints of swelling of his neck and cough. He had been diagnosed with multinodular goiter, obesity, pre-diabetes, and hypogonadism....

IntroductionThe term factitious thyrotoxicosis is defined as an excess of thyroid hormone in the body caused by the ingestion of exogenous thyroid hormone. It can be intentional, usually in patients with psychiatric disorders, or accidentally. Another possible cause is the inappropriate use of thyroid hormone for the treatment of obesity, depression or infertility.Case reportWe present the case of a 32-year-o...

Background: Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing’s syndrome. The clinical application of adrenal venous sampling (AVS) in diagnostic work-up for PBMAH is still controversially discussed. AVS might be useful in evaluating the predominant side and guiding the decision for unilateral adrenalectomy in PBMAH.Objectives: Our aim was to evaluate whether certain metabolites in AVS samp...