Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep653 | Pituitary and Neuroendocrinology | ECE2022

The impact of Sheehan Syndrome on bone mineral density

Salah Ameni , Maaroufi Amel , Ajili Rihab , Saad Ghada , Hasni Yosra , Ach Koussay

Introduction: Sheehan syndrome (SS), or postpartum pituitary necrosis, is a complete or dissociated adeno-pituitary insufficiency due to hypovolemia secondary to excessive blood loss during or after delivery. Although few studies have investigated osteoporosis in isolated hormone deficiencies, the relationship between SS and osteoporosis has not been investigated in large series of SS. In this study, we aimed to evaluate bone mineral density (BMD) in patients with SS.<p cl...

ea0081ep725 | Pituitary and Neuroendocrinology | ECE2022

Decreased quality of life in adult patients with sheehan syndrome

Salah Ameni , Maaroufi Amel , Ajili Rihab , Saad Ghada , Hasni Yosra , Ach Koussay

Introduction: Sheehan Syndrome (SS) is the oldest known cause of non-tumor acquired anterior pituitary insufficiency in women. The incidence of SS would probably have decreased in recent decades in developed countries thanks to the development of obstetric care. However, it still remains a public health problem in developing countries. In addition, it constitutes a chronic disabling pathology and is strongly linked to an alteration of the quality of life. In this study we aime...

ea0090p318 | Calcium and Bone | ECE2023

Rare association of primary hyperparathyroidism with type 3 multiple autoimmune syndrome

Aycha Ghachem , Elfekih Hamza , Ghada Sabbagh , Saad Ghada , Fatma Barkallah , Hasni Yosra , Chadli Chaieb Molka

Introduction: Primary hyperparathyroidism (PHPT) is most commonly sporadic and in rare circumstances, it can develop as part of multiple endocrine neoplasia (MEN). There are few cases described in the literature reporting an association of PHPT with myasthenia gravis and multiple autoimmune syndrome (MAS). These patients may present only with clinical signs of PHPT making it difficult to suspect the coexistence of MAS. Here, we report the case of type 3 MAS in a woman with PHP...

ea0090p245 | Thyroid | ECE2023

Large rapidly developing goiter and Acute Leukemia

Ben Hadj Slama Nassim , Saad Ghada , Asma Gorchene , Elfekih Hamza , Kacem Maha , Molka Chadli

Introduction: Many thyroid conditions are associated with the development of a rapidly progressing goiter and should evoke several diagnoses, some of which may be of poor prognosis.Case-presentation: A 47-year-old female patient with no previous pathological history presented with a large goiter associated with a deteriorated general condition that had been evolving for 3 weeks On examination, she presented with a fever at 39°C, multiple cervical ad...

ea0090p246 | Thyroid | ECE2023

Hidden central hypothyroidism in an elderly patient following radioiodine therapy

Aycha Ghachem , Elfekih Hamza , Bnina Molka Ben , Saad Ghada , Kenza Houd , Hasni Yosra , Chadli Chaieb Molka

Introduction: Thyrotropin deficiency is a rare etiology of hypothyroidism. The diagnosis can be easily confirmed in case of low FT4 level associated with normal or low TSH value. In patients with peripheral hypothyroidism treated by levothyroxine, this biochemical profile become difficult to find. Herein, we describe the case of a patient with peripheral hypothyroidism due to radioiodine therapy in whom the diagnosis of central hypothyroidism was made.Ob...

ea0090p785 | Thyroid | ECE2023

Thyroid nodular disease in a patient with Neurofibromatosis type 1

Aycha Ghachem , Elfekih Hamza , Ghada Sabbagh , Saad Ghada , Kenza Houd , Hasni Yosra , Chadli Chaieb Molka

Introduction: Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease. Patients affected by NF1 have an increased risk of developing tumors other than neurofibromas, especially of endocrine origin, thatÂ’s why this patients should be screened for endocrine lesions. In this report, we describe a patient affected by NF1 who present a thyroid nodule.Observation: A 27-year-old woman was admitted in our department for endocrinological evaluati...

ea0090ep105 | Adrenal and Cardiovascular Endocrinology | ECE2023

Clinical and biological features of late-onset congenital adrenal hyperplasia

Ben Hadj Slama Nassim , Ach Taieb , Saad Ghada , Asma Gorchene , Abdelkarim Asma Ben

Introduction: 21-hydroxylase deficiency represents 95% of congenital adrenal hyperplasia. The non-classical form manifests in women mainly by hirsutism, menstrual disorders, or infertility. We present three patientsÂ’ cases.Observations: Patient N.C., 17 years old, who presented with hirsutism beginning at the age of 8 years and progressively worsening after puberty. The patient had her menarche at the age of 9 years, with short and irregular menses....

ea0090ep351 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Predictive factors of diabetic nephropathy in type 2 diabetics

Nouira Sawsen , Ach Taieb , Abdelkarim Asma Ben , Saad Ghada , Chaieb Molka Chadli

Introduction: Uncontrolled hyperglycemia in diabetes is a common cause of microvascular complications, including diabetic nephropathy (DN). Despite improvements in the management of type 2 diabetes (T2DM), diabetic nephropathy is still associated with high morbidity and mortality. The objective of our study is to evaluate the predictive factors of DN in adults with T2DM in order to prevent its development.Patients and Methods: A retrospective study, incl...

ea0090ep746 | Pituitary and Neuroendocrinology | ECE2023

Tumor mimicking ampullary carcinoma in a patient with acromegaly

Bnina Molka Ben , Ghada Sabbagh , Elfekih Hamza , Saad Ghada , Fatma Barkallah , Hasni Yosra , Chaieb Molka Chadli

Introduction: Acromegaly is the set of clinical manifestations induced by chronic exposure to an endogenous excess of growth hormone (GH). Most often, acromegaly is related to GH production by a pituitary adenoma. It may be associated with neuroendocrine tumors of the pancreas as part of multiple endocrine neoplasia type 1 (MEN1). Herein, we described a tumor mimicking a carcinoma of the Ampulla of Vater in a patient with acromegaly.Observation: A 54-yea...

ea0090ep790 | Pituitary and Neuroendocrinology | ECE2023

Werner syndrome and endocrine involvement: A case report

Slama Nassim Ben Hadj , Saad Ghada , Asma Gorchene , Ach Taieb , Kacem Maha , Ach Koussay

Introduction: Werner syndrome is a rare genetic disease affecting the WRN gene, of autosomal recessive inheritance.Case-presentation: We report the case of a 34-year-old patient who presented with erectile dysfunction and asthenia. His brother underwent surgery for meningioma. He was also diagnosed with hypogonadism, suffered from bilateral cataract and diabetes, and died following acute Leukemia at the age of 35 years. Our patient is from a second-degre...