Endocrine Abstracts

Introduction: Sheehan syndrome (SS), or postpartum pituitary necrosis, is a complete or dissociated adeno-pituitary insufficiency due to hypovolemia secondary to excessive blood loss during or after delivery. Although few studies have investigated osteoporosis in isolated hormone deficiencies, the relationship between SS and osteoporosis has not been investigated in large series of SS. In this study, we aimed to evaluate bone mineral density (BMD) in patients with SS.<p cl...

Introduction: Sheehan Syndrome (SS) is the oldest known cause of non-tumor acquired anterior pituitary insufficiency in women. The incidence of SS would probably have decreased in recent decades in developed countries thanks to the development of obstetric care. However, it still remains a public health problem in developing countries. In addition, it constitutes a chronic disabling pathology and is strongly linked to an alteration of the quality of life. In this study we aime...

Introduction: Primary hyperparathyroidism (PHPT) is most commonly sporadic and in rare circumstances, it can develop as part of multiple endocrine neoplasia (MEN). There are few cases described in the literature reporting an association of PHPT with myasthenia gravis and multiple autoimmune syndrome (MAS). These patients may present only with clinical signs of PHPT making it difficult to suspect the coexistence of MAS. Here, we report the case of type 3 MAS in a woman with PHP...

Introduction: Many thyroid conditions are associated with the development of a rapidly progressing goiter and should evoke several diagnoses, some of which may be of poor prognosis.Case-presentation: A 47-year-old female patient with no previous pathological history presented with a large goiter associated with a deteriorated general condition that had been evolving for 3 weeks On examination, she presented with a fever at 39°C, multiple cervical ad...

Introduction: Thyrotropin deficiency is a rare etiology of hypothyroidism. The diagnosis can be easily confirmed in case of low FT4 level associated with normal or low TSH value. In patients with peripheral hypothyroidism treated by levothyroxine, this biochemical profile become difficult to find. Herein, we describe the case of a patient with peripheral hypothyroidism due to radioiodine therapy in whom the diagnosis of central hypothyroidism was made.Ob...

Introduction: Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease. Patients affected by NF1 have an increased risk of developing tumors other than neurofibromas, especially of endocrine origin, that’s why this patients should be screened for endocrine lesions. In this report, we describe a patient affected by NF1 who present a thyroid nodule.Observation: A 27-year-old woman was admitted in our department for endocrinological evaluati...

Introduction: 21-hydroxylase deficiency represents 95% of congenital adrenal hyperplasia. The non-classical form manifests in women mainly by hirsutism, menstrual disorders, or infertility. We present three patients’ cases.Observations: Patient N.C., 17 years old, who presented with hirsutism beginning at the age of 8 years and progressively worsening after puberty. The patient had her menarche at the age of 9 years, with short and irregular menses....

Introduction: Uncontrolled hyperglycemia in diabetes is a common cause of microvascular complications, including diabetic nephropathy (DN). Despite improvements in the management of type 2 diabetes (T2DM), diabetic nephropathy is still associated with high morbidity and mortality. The objective of our study is to evaluate the predictive factors of DN in adults with T2DM in order to prevent its development.Patients and Methods: A retrospective study, incl...

Introduction: Acromegaly is the set of clinical manifestations induced by chronic exposure to an endogenous excess of growth hormone (GH). Most often, acromegaly is related to GH production by a pituitary adenoma. It may be associated with neuroendocrine tumors of the pancreas as part of multiple endocrine neoplasia type 1 (MEN1). Herein, we described a tumor mimicking a carcinoma of the Ampulla of Vater in a patient with acromegaly.Observation: A 54-yea...

Introduction: Werner syndrome is a rare genetic disease affecting the WRN gene, of autosomal recessive inheritance.Case-presentation: We report the case of a 34-year-old patient who presented with erectile dysfunction and asthenia. His brother underwent surgery for meningioma. He was also diagnosed with hypogonadism, suffered from bilateral cataract and diabetes, and died following acute Leukemia at the age of 35 years. Our patient is from a second-degre...