Searchable abstracts of presentations at key conferences in endocrinology

ea0081p611 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Influence of dopamine receptor d2 and dopamine transporter polymorphisms in angiopathy in patients with type 2 diabetes mellitus

Neves Marta , Santos Ana Carolina , Ferreira Joana , Raposo Joao F. , Valente Ana , Bicho Manuel

Introduction and Aim: Dopamine receptor D2 (DRD2) polymorphism (rs1800497) appears to be associated with increased susceptibility to the development of type 2 diabetes mellitus (T2DM). The dopamine transporter (DAT) determines dopamine signalling, responsible for the reuptake of its active form from the synapse. Polymorphism in the DAT gene (rs2836317) can increase dopamine reuptake in the synaptic cleft. However, its association with T2DM is still controversial.<p class="...

ea0073aep228 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Association of IDO polymorphism with oxidative status, metabolic control and inflammation in patients with type 2 diabetes mellitus

Neves Marta , Bicho Manuel , Santos Ana Carolina , João F. Raposo , Valente Ana

IntroductionThe Indoleamine 2.3-dioxygenase (IDO) is an enzyme involved in tryptophan metabolism, encoded by the IDO1 gene in humans. In Caucasians, the rs9657182 polymorphism of IDO gene was found to be associated with neurobehavioral complications, especially depression. Several studies in Type 2 Diabetes Mellitus (T2DM) describe psychological factors as barriers to the successful implementation of a healthy eating plan. According to our knowledge ther...

ea0081p550 | Calcium and Bone | ECE2022

Biochemical parameters in metabolic bone disease of obese patients

Binda Pereira Raquel , Santos Ana Carolina , Ferreira Joana , Mascarenhas Mario Rui , De Quinhones Levy Pilar , Barbosa Paula , Bicho Manuel

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

ea0073aep409 | General Endocrinology | ECE2021

Characterization of neuroinflammatory makers and related-genetic variants in athletes from a long duration ultramarathon mountain cycling race and endurance exercises

Matos Andreia , Matinho Miguel , Fontes Miguel , Santos Ana Carolina , Ângela Gil , Cardoso Carlos , Bicho Manuel , Alonso Isanete

IntroductionExercise induces changes in the inflammatory profile that can comprehend changes during and immediately after exercise with long-term effects. This inflammatory profile could impact the cognitive function and so, the performance.ObjectivesCompare the inflammatory status from long duration and endurance exercises and correlate it with an immune and neuroendocrine genetic profile.<p class="abste...

ea0090rc1.4 | Rapid Communications 1: Diabetes, Obesity, Metabolism and Nutrition 1 | ECE2023

Angiotensin-converting enzyme in type II diabetes: effects of combined training on cardiovascular components and blood components

Matos Andreia , Gil Angela , Alonso Isanete , P. Magalhaes Joao , Santos Ana Carolina , Ribeiro Rogerio , F. Raposo Joao , B. Sardinha Luis , Bicho Manuel

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...