Endocrine Abstracts

Introduction and Aim: Dopamine receptor D2 (DRD2) polymorphism (rs1800497) appears to be associated with increased susceptibility to the development of type 2 diabetes mellitus (T2DM). The dopamine transporter (DAT) determines dopamine signalling, responsible for the reuptake of its active form from the synapse. Polymorphism in the DAT gene (rs2836317) can increase dopamine reuptake in the synaptic cleft. However, its association with T2DM is still controversial.<p class="...

IntroductionThe Indoleamine 2.3-dioxygenase (IDO) is an enzyme involved in tryptophan metabolism, encoded by the IDO1 gene in humans. In Caucasians, the rs9657182 polymorphism of IDO gene was found to be associated with neurobehavioral complications, especially depression. Several studies in Type 2 Diabetes Mellitus (T2DM) describe psychological factors as barriers to the successful implementation of a healthy eating plan. According to our knowledge ther...

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

IntroductionExercise induces changes in the inflammatory profile that can comprehend changes during and immediately after exercise with long-term effects. This inflammatory profile could impact the cognitive function and so, the performance.ObjectivesCompare the inflammatory status from long duration and endurance exercises and correlate it with an immune and neuroendocrine genetic profile.<p class="abste...

Objectives: The angiotensin-converting enzyme (ACE1) gene is one of the most studied genes in the pathogenesis of type II diabetes (T2DM) and cardiovascular disease. However, in the context of exerciSemodels in T2DM, they are not yet fully understood. We intended to characterize the genetic profile of individuals with T2DM from an inter-individual point of view using prognostic markers and cardiovascular risk. On the other hand, relate it with the profile obtained wit...