Searchable abstracts of presentations at key conferences in endocrinology

ea0020p216 | Endocrine tumours and neoplasia | ECE2009

Insulinomas: experience of Coimbra’s University Hospital, Endocrinology Department

Santos Jacinta , Paiva Isabel , Martinho Mariana , Vieira Alexandra , Carvalheiro Manuela

Background: Insulinomas are rare neuroendocrine tumours (4 cases/million patients per year), representing an important cause of hyperinsulinemia. Usually are benign and sporadic, but can be part of multiple endocrine neoplasias. To establish the diagnosis it is essential to document inappropriately high levels of insulin during episodes of hypoglycaemia.Aim: Retrospective analysis of the clinical files of the patients followed in our department since Jan...

ea0016p298 | Endocrine tumours | ECE2008

Cyclic Cushing disease: clinical case

Santos Jacinta , Baptista Carla , Paiva Isabel , Rito Manuel , Carvalheiro Manuela

Cyclic CushingÂ’s disease is a rare situation due to episodic hypersecretion of ACTH. Suspicion is raised when strong clinical stigmata occur, with normal basal values of cortisol and normal responses to dynamic tests. After performing several tests, particularly during phases without symptoms (well-being), the probability of successful diagnosis increases.We describe the case of a 33 years old female patient with full-blown clinical picture (weight ...

ea0081p290 | Calcium and Bone | ECE2022

Utility of intraoperative parathyroid hormone monitoring to predict success of parathyroidectomy for primary hyperparathyroidism

Elvas Ana Rita , Fernandes Andreia , Couto Joana , Martins Raquel G. , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (pHPT) and has been traditionally performed through bilateral neck exploration (BNE). However, with the use of intraoperative parathyroid hormone (IOPTH) assay along with preoperative localization exams, minimally invasive surgery can be performed with good surgical success rate.Aim: To evaluate the usefulness of IOPTH assay in guiding adequate parathyroidectom...

ea0081p310 | Calcium and Bone | ECE2022

Impact of hypoparathyroidism on quality of life in patients with differentiated thyroid cancer

Elvas Ana Rita , Marques Bernardo , Couto Joana , Martins Raquel G. , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Hypoparathyroidism (hypoPTH) is one of the most feared iatrogenic complications of the surgical treatment for thyroid cancer (TC). Despite supplementation with calcium salts and calcitriol, hypoPTH seems to be associated with a negative impact on quality of life (QoL), which has not been evaluated in the Portuguese patients.Objectives: To evaluate the impact of hypoPTH on the QoL of Portuguese patients with TC and its correlation with serum...

ea0081p495 | Thyroid | ECE2022

A rare case of a non-secretory medullary thyroid carcinoma

Rita Elvas Ana , Couto Joana , Martins Raquel G. , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor (1-2% of all thyroid carcinomas), which arises from calcitonin-producing C cells. Calcitonin (CT) and carcinoembryonic antigen (CEA) are used as tumor markers in the follow-up of patients with MTC. Non-secretory forms of MTC are very rare, accounting for less than 1% of the cases.Case Report: A 53-year-old man underwent left thyroid lobectomy for a 1.1 cm thyroid nodule subjec...

ea0081ep77 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenocortical carcinoma: experience of a tertiary center

Elvas Ana Rita , Couto Joana , Martins Raquel G , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis. Objective: The aim of this study is to characterize patients with ACC followed at a tertiary center. Material and Methods: Retrospective analysis of clinical records of patients with histopathological diagnosis of ACC followed in our clinic. Results and conclusions: We reviewed 11 patients. The average age at diagnosis was 57.3±15.2 years and 63.6% were females. Seven patients...

ea0081ep213 | Calcium and Bone | ECE2022

Primary hyperparathyroidism – experience of a single center

Elvas Ana Rita , Couto Joana , Martins Raquel G. , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Primary hyperparathyroidism (pHPT) is the most common cause of hypercalcemia in the outpatient setting and is a frequent endocrine disorder. Large cohort studies of pHPT patients in the Portuguese population are scarce. Aim: To characterize patients with pHPT followed at a tertiary center.Material and Methods: Retrospective analysis of clinical records of patients with pHPT followed in our hospital from 2003 to 2021. ...

ea0063p875 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Clinical spectrum of MEN1: what about other non-endocrine neoplasias?

Marques Bernardo , Martins Raquel G , Elvas Ana Rita , Couto Joana , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1) is a hereditary autosomal dominant disorder caused by germline mutations in the MEN1 tumour-suppressor gene and is typically characterized by parathyroid adenomas, duodenopancreatic neuroendocrine tumors (NETs) and pituitary adenomas. Breast cancer has recently been identified as manifestation of MEN1 and female patients have early onset elevated breast cancer risk.Case report: Female pati...

ea0063p1191 | Thyroid 3 | ECE2019

Differentiated thyroid cancer treated with lobectomy: assessment of response to therapy

Rodrigues Fernando Elvas Ana Rita , Martins Raquel G , Couto Joana , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Background: Assessment of response to therapy is a valid tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC). It is well documented in patients treated with total thyroidectomy and radioiodine ablation therapy (RAI), but data is still sparse regarding patients treated with lobectomy. Our study aimed to evaluate response to therapy in patients with DTC treated with lobectomy.Methods: We performed a retrospective study...

ea0049ep1463 | Thyroid (non-cancer) | ECE2017

Lymph node metastases location (central vs lateral neck) in well-differentiated thyroid carcinoma: Is it important?

Marques Bernardo , Martins Raquel , Couto Joana , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Regional lymph node (LN) metastases have prognostic significance in differentiated thyroid cancer (DTC). Several studies demonstrated that lateral neck LN metastasis, classified as N1b, have a greater impact on overall survival than central LN metastasis. Our study aimed to assess the risk of N1a vs N1b involvement on outcome in patients with differentiated thyroid cancer (DTC), according to the 7th edition of the TNM staging system.Methods...