Endocrine Abstracts

Insulinoma is the most common cause of hypoglycemia related to endogenous hyperinsulinism in adults. It is very rare in pregnancy, fewer than 30 cases of insulinoma presenting in pregnancy have been reported so far and it’s managment is very challenging. We raported here the case of a pregnant women aged 35 years presenting an insulinoma.The diagnosis was made 1 year ago in the presence of hypoglycemia, high levels of inulin and C-peptide and a 10 m...

Introduction: The thyroid hypofunction is at origin of lipid metabolism disorder that enhances cardiovascular risk and increases morbidity and mortality.Objective: Search for lipid disorders in hypothyroidism comparing the results between the two sexes.Population and Method: Retrospective study of 72 patients (54 F and 18 H), mean age of 55.63 years (53.66 F and 61.5 H) hospitalized between 1996 and 2012 for primary hypothyroidism....

Introduction: Pericarditis includes all inflammatory affections of the serous covering of the heart. The clinical expression and etiology of these disorders are highly variable. Of these, hypothyroidism is an important issue to recognize.Objective: Find the frequency of pericardial effusion in primary hypothyroidism and appreciate its clinical and evolutionary characteristics.Population and method: A retrospective study in 72 patie...

Achondroplasia is the most common genetic causes dwarfism. Its prevalence is 1/10 000 à 30 000 birth. it is an autosomal dominant disease associated with the mutation of the receptor gene growth factor on chromosome 4p16 fibroblastes FGFR3 responsable rhizomelic dwarfism and multiple complications likely to compromise the functional and vital prognosis of patients.Aim: Find the frequency of neurological complications and identify scalability.<p ...

Introduction: Glucose metabolism disorders are well known in subjects with GH excess, but little is known about other metabolic abnormalities. Our aim is to analyze metabolic complications in subjects with acromegaly and pituitary gigantism.Subjects and methods: Records of 111 subjects were retrospectively examined, mean GH=62 ng/ml (n<5), mean age=39.11 (14–60). All had routine analysis for fasting blood glucose, cholesterol, triglycer...

The medullary carcinoma of thyroid is rare and represent 5–10% of the thyroid cancers. It appears under sporadic and family forms in more than a third of cases. It becomes integrated them into the multiple endocrine neoplasms type 2 of autosomique dominant transmission associate with germinal mutations of the gene RET. We bring report in this study, the observation of a new family shape. BL index case was diagnosed in the age of 42 years further to the appearance of a sev...

Introduction: Pituitary adenomas in general are deemed to be more aggressive in males. Our aim is to analyze somatotrop adenomas (SA) characteristics and neurological complications. In the second time we will compare male and female cases.Subjects and methods: In this retro-and prospective study, 112 pure and mixed SA diagnosed between 1980 and 2012 were analyzed. They all had hormonal assessment (GH before and after OGTT±IGF1, PRL, cortisol, ACTH, ...

The Silver–Russell syndrome (SRS) is a sporadic heterogeneous disorder, clinically and genetically. The intrauterine growth retardation (IUGR), short stature because of lack of catch-up growth, relative macrocrania and limb asymmetry are the major diagnostic criterias, associated with a large clinical criterias (minor criteria).We report a case series of 15 cases with SRS, our goal is to relate the frequency of each symptom of the diagnostic criteri...