Endocrine Abstracts

Introduction: Osteopenia and osteoporosis develop with aging in thalassemia patients despite clinical treatment therapy has improved. Bisphosphonates, which are potent inhibitors of osteoclastic bone resorption, have been recently used to correct the bone abnormality in thalassemia with encouraging results. Bisphosphonates are a class of drugs that prevent the loss of bone mass, used to treat osteoporosis and similar diseases. They are the most commonly prescribed drugs used t...

Aim: Obesity can be addressed through lifestyle interventions like modifying diet and engaging in physical activity. In cases where these measures prove ineffective, there is the option of administering medication (RxOb) or of surgical intervention. Sentiment analysis (SA) is an automated procedure employed to extract emotional information prevalent in a given body of text. Specifically, SA enables the determination of the "sentiment polarity" –whether the overall...

Introduction: Poorly differentiated thyroid carcinoma is a tumor of follicular origin with morphological and biological characteristics between anaplastic and well differentiated carcinoma. It accounts for less than 5% of all thyroid tumors and is characterized by adverse prognosis, aggressive behavior and frequently distant metastases, mainly to lungs and bones and to a lesser extent to brain, liver, kidney, breast and skin. Incident presentation: We report a case of a patien...

Introduction: Adrenal masses usually represent benign and nonfunctional adrenal adenomas however, primary or metastatic malignancy should also be considered. Discovery of an adrenal mass needs further evaluation in order to exclude malignancy and hormonal secretion. Primary adrenal melanoma is an extremely rare entity, while metastases of cutaneous melanoma to the adrenals occur much more often. We present a rare case of a possibly primary adrenal malignant melanoma with imagi...

Meningioma is a common, usually benign, tumor of the brain and the spinal cord that originates from any dura surface. Such lesion accounts for 10 to 15% of nonadenomatous sellar masses. Purely intrasellar meningiomas are relatively rare and can mimic a nonfunctioning adenoma. A 33-year-old man with a history of 1.5 year fatigue, anemia and erectile dysfunction referred to our department. The laboratory data revealed low levels of ACTH, Cortisol, FSH, LH and Testosterone, while...

We report on a case of a 63-year-old male patient with a history of metastatic DTC, with both lung and bone metastases and an additional paravertebral mass. The patient presented with enlargement of the left thyroid lobe. FNA was positive for malignancy and subsequent CTs were negative for distant metastases, whereas laboratory tests showed elevated thyroglobulin (Tg>500 ng/ml). The patient underwent total thyroidectomy and the pathology report revealed a multifocal, folli...

Introduction: Pheochromocytomas (PCCs) are rare neuroendocrine catecholamine secreting-tumors derived from chromaffin cells of the adrenal medulla. PCCs are usually solid tumors but rarely occur as a cystic lesion. Cystic pheocromocytomas (CPCCs) are usually asymptomatic, unilateral and of a large size without typical radiological and biochemical features of pheochromocytomas. Non-specific abdominal pain has been reported in several cases.Case Presentati...

Introduction: Anaplastic thyroid carcinoma (ATC) accounts for 1.7% of all thyroid cancers with poor prognosis and a median survival of 4 to 12 months. We report a case of ATC with small intestine perforation due to metastasis in the jejunum.Case report: A 57-year-old woman was referred to our department for a rapidly enlarging goiter and dyspnea. Her latest thyroid ultrasound was performed about a month ago and demonstrated 2 nodules measuring 21×16...

Introduction: Somatostatin analogues (SSAs) are the mainstay of treatment for carcinoid syndrome (CS)-related symptoms. Controversy still exists regarding the extent of the efficacy of this intervention. The purpose of the systematic review and meta-analysis was to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of SSAs (lanreotide, octreotide, pasireotide) in patients with CS. Due to lack of uniformity and established criteria...

Background: Milk- alkali syndrome (MAS), characterized by the triad of hypercalcemia, metabolic alkalosis, and renal dysfunction, is increasingly recognized as a complication of calcium supplementation, particularly in the management of hypoparathyroidism. Some have proposed should be called calcium- alkali syndrome (CAS). We delineate two cases of CAS and provide a review of relevant literature, emphasizing the endocrine aspects of CAS.Case Presentation...