Searchable abstracts of presentations at key conferences in endocrinology

ea0035p710 | Neuroendocrinology | ECE2014

Meal-induced plasma ghrelin suppression in different phases of anorexia nervosa

Polli Nicoletta , Giunta Francesca , Cesari Miriam , Zappulli Daniela , Scacchi Massimo , Persani Luca

Introduction: The ghrelin suppressive effect of food is well established in normal subjects, whereas the effectiveness of meals in decreasing plasma ghrelin in patients with anorexia nervosa (AN) is still debated. Based on the above, we elected to study the ghrelin dynamics after food or placebo in a group of anorectic girls at the moment of diagnosis and after weight recuperation.Study design: Nine anorectic women (age 14–32 years) were studied. Bo...

ea0032p808 | Paediatric endocrinology | ECE2013

Sex steroid priming in differential diagnosis between idiopathic GH deficiency and constitutional delay of growth and puberty

Radin Raffaella , Moro Mirella , Scacchi Massimo , Cavagnini Francesco , Danesi Leila , Persani Luca

Priming with sex steroids prior to stimulation tests for the diagnosis of GH deficiency (GHD) in peripubertal years remains controversial, though some evidence suggests its utility in improving the specificity of GH testing for the distinction between idiopathic GHD (IGHD) and constitutional delay of growth and puberty (CDGP). However, few data are available on the final height (FH) of untreated CDGP patients. In order to better understand the usefulness of priming, we analyze...

ea0022p562 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Assessment of biochemical control of acromegaly during treatment with somatostatin analogues: is there still a role for glucose oral load?

Carzaniga Chiara , Scacchi Massimo , Vitale Giovanni , Fatti Maria Letizia , Giraldi Francesca Pecori , Andrioli Massimiliano , Cavagnini Francesco

Biochemical control of acromegaly is currently defined by the achievement of GH suppression after oral glucose tolerance test (OGTT) and of normal age- and gender-matched IGF1 levels. OGTT is believed to inhibit somatotropin secretion by enhancing central somatostatinergic tone; thus, the use of this test in evaluating biochemical control in acromegalic patients on somatostatin analogues (SSA) is questionable. To gain further insights into this topic, we analyzed basal and nad...

ea0056gp144 | Neuroendocrinology | ECE2018

Genetics of binge-eating disorder (BED): a pilot study

Cacciatore Chiara , Vezzoli Valeria , Duminuco Paolo , Scacchi Massimo , Mai Stefania , Polli Nicoletta , Persani Luca

Binge-eating disorder (BED) is characterized by recurrent (≥1 per week for 3 months), brief (≤2 h), psychologically distressing binge-eating episodes during which patients sense a lack of control and consume larger amounts of food than most people would under similar circumstances. The prevalence of BED is estimated to be between 2% and 3.5% and majority of individuals with BED are either overweight or obese. Most of the genetic research about eating disorders (ED)...

ea0022p561 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The diagnosis of GH deficiency in obese patients: what help from pharmacological blockade of lipolysis?

Orsini Federica , Cattaneo Agnese , Grasso Alice , Filippini Barbara , Fatti Maria Letizia , Moro Mirella , Scacchi Massimo , Cavagnini Francesco

The diagnostic approach to GH deficiency (GHD) in obese patients is complicated by the reduced spontaneous and stimulated GH secretion associated with overweight. A GH response to GHRH+arginine lower than 4.2 μg/l is currently considered indicative of GHD in obesity (Corneli et al., Eur J Endocrinol 2005). Aim of the study was to verify the diagnostic validity of this cut-off value by investigating the effect of acute pharmacological blockade of lipolysis on...

ea0020p242 | Bone/Calcium | ECE2009

Peculiar features of bone disease in thalassemia: comparison with anorexia nervosa

Cattaneo Agnese , Danesi Leila , Scacchi Massimo , Carzaniga Chaiara , Vai Silvia , Ortolani Sergio , Cappellini Maria Domenica , Cavagnini Francesco

In thalassemic patients individual values of BMD measured by traditional DEXA are lower than those determined by QCT. The reason for this discrepancy is still controversial.Aim: To investigate bone features in a large group of thalassemic patients, compared with patients with anorexia nervosa, also characterized by precocious osteoporosis.Study design: Forty-six adult thalassemic subjects and 25 anorectic women were studied. In all...

ea0081p82 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Irisin in pediatric patients with Prader Willi Syndrome: the role of body composition and glucose metabolism

Mai Stefania , Fintini Danilo , Mele Chiara , Convertino Alessio , Bocchini Sarah , Grugni Graziano , Aimaretti Gianluca , Vietti Roberta , Scacchi Massimo , Crino Antonino , Marzullo Paolo

Irisin is a myokine involved in the browning of white adipose tissue and in the regulation of energy expenditure, glucose tolerance and insulin sensitivity. It was previously demonstrated that obese adults with Prader-Willi syndrome (PWS) harbor lower irisin levels than individuals with common obesity. Significant associations seem to relate irisin to muscle mass, REE, insulin resistance and triglycerides and also the strongest independent predictors of irisin levels were PWS ...

ea0026p132 | Growth factors | ECE2011

Bone turnover and mineral density in thalassemia: relationships with gh secretory status and circulating somatomedins

Danesi Leila , Cattaneo Agnese , Scacchi Massimo , Sciortino Giovanna , Vitale Giovanni , Domenica Cappellini Maria , Arvigo Marica , Ferone Diego , Minuto Francesco , Cavagnini Francesco

Introduction: Previous data from our group suggested a role for the GH/IGF1 axis in the pathophysiology of osteoporosis in thalassemia (Clin Endocrinol 69:202, 2008). The present study was aimed at evaluating the relationships between circulating IGFs and bone metabolism and density in a very large series of adult thalassemic patients.Study design: One hundred and thirty-nine patients affected by thalassemia major (mean age 32.3±7.87 years) underwen...

ea0016p66 | Bone and calcium | ECE2008

Osteopenia/osteoporosis in adult thalassemic patients: contribution of growth hormone - insulin-like growth factor I deficiency

Scacchi Massimo , Danesi Leila , Cattaneo Agnese , Valassi Elena , Pecori Giraldi Francesca , Argento Crocetta , D'Angelo Emanuela , Mirra Nadia , Zanaboni Laura , Tampieri Benedetta , Cappellini Maria Domenica , Cavagnini Francesco

GH and IGF-I exert an important role in the control of bone formation. Osteopenia and osteoporosis are a frequent recurrence in patients with thalassemia. Due to the high prevalence of GH deficiency (GHD) in adult thalassemic patients (Scacchi et al., Clin Endocrinol 2007), we investigated the possible role of GH - IGF-I abnormalities in the pathogenesis of the osteopenia/osteoporosis of this disease.Study: Sixty-four adult thalassemic pati...

ea0014p181 | (1) | ECE2007

The growth hormone – insulin-like growth factor-I axis in adult thalassemic patients

Danesi Leila , Cattaneo Agnese , Valassi Elena , Scacchi Massimo , D’Angelo Emanuela , Mirra Nadia , Zanaboni Laura , Cappellini Maria Domenica , Cavagnini Francesco

GH deficiency (GHD) can be recognized in a not negligible proportion of thalassemic children, while data on the prevalence of this disorder in adult patients are lacking. Therefore, we elected to study the GH – IGF-I axis in a large group of adult thalassemic subjects.Study design: Ninety-four patients (69 with thalassemia major and 25 with thalassemia intermedia on stable transfusional regimen, 39 men and 55 women, aged 31.5±6.8 years, receivi...