Endocrine Abstracts

Today calcitonin (CT) and carcinoembryonic antigen (CEA) are widely used as markers of medullary thyroid carcinoma (MTC). Postoperative CT and CEA normalization is a favorable prognostic factor. The work was initiated to assess CEA diagnostic and prognostic value before and after surgery in patients with familial medullary thyroid carcinoma (FMTC). Methods: blood serum from 11 patients with FMTC (mean age 27.4 plus/minus 3.2) undergoing total thyroidectomy and lymph node disse...

Purpose: To evaluate the level of intellect according to tests data in the regions with iodine deficiency.Methods: In the frame the ‘Thyromobil’ project that was held during 2003-2005y in 18 regions of Russian Federation were done standartized epidemiologic research. The research included clinical examination, palpation thyroid, ultrasonic examination of thyroid, definitions of ioduria. We used Cattell test, free of cultural influence (Culture ...

Background: Statins are widely prescribed cholesterol-lowering drugs. They inhibit cholesterol synthesis through inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. They have also been recently identified as bone stimulatory agents (Mundy et al., 1999). They have been found to increase the expression of BMP-2 that triggers a cascade of events leading to increased bone formation. However, the exact mechanism for the stimulatory action of statins is not fully elucidat...

Actuality: According to the World Health Organization, the escalating international epidemic of obesity is now the most significant contributor to ill health. More than 30% of US adults are obese, i.e. body mass index (BMI) 30 kg/m2, and it is feared that one in three children born in the early 21st century will develop diabetes with a consequent reduction in lifetime expectancy. In Uzbekistan 20.2% of population is obese.Aims of study: Examin...

Uzbekistan is area of low dietary iodide intake (45.5% of population with iodide deficiency) and high goiter prevalence (more then 40%).Objective: The aim of this study was to investigate the prevalence of amiodarone-induce thyroid disorders among patients residence in iodine deficiency region.Patients and methods: We observed 46 patients with supraventricular or ventricular arrhythmias, aged 53±12 years. The mean duration of ...

Introduction: The thyroid hypofunction is at origin of lipid metabolism disorder that enhances cardiovascular risk and increases morbidity and mortality.Objective: Search for lipid disorders in hypothyroidism comparing the results between the two sexes.Population and Method: Retrospective study of 72 patients (54 F and 18 H), mean age of 55.63 years (53.66 F and 61.5 H) hospitalized between 1996 and 2012 for primary hypothyroidism....

Introduction: Pericarditis includes all inflammatory affections of the serous covering of the heart. The clinical expression and etiology of these disorders are highly variable. Of these, hypothyroidism is an important issue to recognize.Objective: Find the frequency of pericardial effusion in primary hypothyroidism and appreciate its clinical and evolutionary characteristics.Population and method: A retrospective study in 72 patie...

Case history: This 33-year old Scottish female presented in February 2017 with a 3-month history of vomiting, erythematous vesicular pruritic rash and three stone weight loss. The rash started 1 day postpartum in January 2015 and migrated from dorsum of feet to both lower legs, upper thigh and torso. A negative biopsy for pemphigus led the team to suspect necrolytic migratory erythema (NME) in November 2016. Her past medical history includes gestational diabetes with her third...

Introduction: Sarcoidosis is a systemic inflammatory disease characterized by noncaseating granulomas. Its pseudo-tumor manifestation in certain organs such as the thyroid can mimic thyroid carcinoma and lead to erroneous therapeutic decisions. We report a case of sarcoidosis with cervical adenopathy initially considered as a cervical metastasis of thyroid cancer.Observation: A 61-year-old woman, with a history of spontaneous subacute subdural hematoma o...

Introduction: Basedowian exophthalmos is an inflammatory disease of the orbit of autoimmune origin, potentially threatening with severe functional and psychosocial effects. It is usually accompanied by hyperthyroidism. It constitutes a real diagnostic challenge in patients with euthyroidism, as is the case with our patient.Observation: A 34-year-old young woman with no particular pathological personal or family history. Who initially consults, a year ago...