Searchable abstracts of presentations at key conferences in endocrinology

ea0075p01 | Pituitary and neuroendocrinology | EYES2021

Leptomeningeal metastasis in a patient with nasosinusal paraganglioma

Cavaco Daniela , Simoes-Pereira Joana

Paragangliomas (PG) originating from the nasal cavity are very rare and usually have an indolent growth. Surgery offers the only possibility of cure for these patients while radiotherapy can only slow their growth rate. Intracranial or leptomeningeal dissemination is very rare, with only 7 cases described in the literature. A 77 year old man with a 4-years history of nasal obstruction. He underwent a nasofibroscopy with a biopsy that revealed a nasosinusal neuroendocrine tumou...

ea0049ep772 | Clinical case reports - Thyroid/Others | ECE2017

Immune checkpoint inhibitors related thyroiditis – a report of two cases

Donato Sara , Antunes Pedro , Simoes-Pereira Joana , Simoes Helder

Introduction: Immune checkpoint inhibitors (ICPIs) are recent approved drugs used in malignant melanoma, non-small-cell lung cancer and renal cell cancer. They act by activating host T cell against malignant antigens. Immune checkpoint blockade can lead to breaking of immune self-tolerance, thereby inducing autoimmune/autoinflammatory side effects, such as endocrinopathies. It may affect thyroid, adrenal and pituitary. We present two ICPIs induced thyroiditis cases.<p clas...

ea0049ep783 | Endocrine Disruptors | ECE2017

Endocrine dysfunctions associated with Hodgkin Lymphoma treatment

Dias Daniela , Simoes-Pereira Joana , Donato Sara , Pereira Conceicao

Introduction: Hodgkin lymphoma (HL) survivors may develop a range of long-term complications that arise years after therapy. Among these, the endocrine dysfunctions are a major concern. Aim: To investigate the long-term endocrine effects of HL treatment.Methods: Revision of the HL patients’ medical files who were followed at our Endocrine Late-effects Clinics.Results: We studied 178 patients (86 (48.3%) were female), whose mea...

ea0049ep1142 | Female Reproduction | ECE2017

How far is possible to make a diagnosis of infertility

Dias Daniela , Simoes-Pereira Joana , Donato Sara , Pereira Conceicao

Introduction: Chemotherapy may be an important cause of primary infertility, especially in girls submitted to this therapy at very young ages.Clinical case: A 20-year-old female was diagnosed with acute lymphoblastic leukaemia at the age of 1. She was submitted to chemotherapy: intrathecal methotrexate and cyclophosphamide and i.v. doxorubicin, vincristine, mercaptopurine, asparaginase and bone marrow transplantation at the age of 2. She was ref...

ea0035p95 | Bone and Osteoporosis | ECE2014

Osteoporosis in young male secondary to cancer treatment: case report

Simoes-Pereira Joana , Silva-Vieira Margarida , Pereira Maria Conceicao

Introduction: Children undergoing treatment for cancer are prone to several long-term endocrine complications, which can permanently affect bone tissue.Case report: A 25-year-old man was diagnosed with right maxillary sinus rhabdomyosarcoma at the age of 5. He was submitted to chemotherapy – intrathecal methotrexate+prednisolone and i.v. vincristine+actinomycin+ifosfamide – and submaxillary+cervical radiotherapy, 60Gy. At the age of 12, he was ...

ea0035p1146 | Thyroid Cancer | ECE2014

Long-term follow-up of young patients submitted to radiotherapy: analysis of ten thyroid cancer cases

Simoes-Pereira Joana , Silva-Vieira Margarida , Pereira Maria Conceicao

Introduction: The increasing risk of thyroid cancer (TC) in patients who underwent radiotherapy is well documented, especially at early ages. In our center, young patients undergoing cancer treatments are referenced to Endocrine Rehabilitation Clinics (ERC). Their risks are initially identified and monitored regularly. We intended to analyze the characteristics and outcomes of patients who developed post-radiotherapy TC.Methods: Medical records of patien...

ea0081p282 | Adrenal and Cardiovascular Endocrinology | ECE2022

Behavior of metastatic paragangliomas and pheocromocytomas: experience from a single center

Verissimo David , damasio ines , Gomes Ana , Simoes-Pereira Joana , Donato Sara , Leite Valeriano

Paragangliomas (PGL) and pheochromocytomas (PHEO) are rare neuroendocrine tumors with an estimated prevalence of 1:6500 and 1:2500, respectively. Although most PGL/PHEO are benign, approximately 10% of PHEOs and 15-35% of PGLs have metastatic disease, which it is main cause of death, with 6 years of median survival. Objective: To characterize the metastatic PHEOs and PGLs from a single center. Methods: Retrospective analysis of clinical records of patients with metastatic PHEO...

ea0081p496 | Thyroid | ECE2022

Outcomes of low-risk differentiated thyroid cancer submitted to radioactive iodine ablation - a comparative analysis in a single tertiary centre

Ivo Catarina , Amaral Sara , Raposo Nuno , Maciel Joana , Simoes Pereira Joana , Vilar Helena , Leite Valeriano

Introduction: The update of 2015 American Thyroid Association (ATA) guidelines recommend that radioactive iodine (RAI) ablation therapy should be used in line with patients’ risk stratification. However, there is no consensus on benefits of post-operative RAI ablation in patients with low risk differentiated thyroid cancer (DTC). The aim of this study is to compare the outcomes of patients with low risk DCT submitted to RAI ablation with those who were not.<p class="a...

ea0081p497 | Thyroid | ECE2022

Impact of 2015 ATA guidelines in 131I prescription in low-risk DTC

Amaral Sara , Ivo Catarina , Cordeiro Raposo Nuno , Maciel Joana , Simoes-Pereira Joana , Vilar Helena , Leite Valeriano

Background: To minimize potential harm from overtreatment of low-risk thyroid cancers, the 2015 American Thyroid Association (ATA) Guidelines recommend that radioactive iodine (RAI) ablation should not be routinely used in low-risk differentiated thyroid carcinoma (DTC). The present study aims to evaluate trends in RAI therapy in a tertiary center after the update of these Guidelines.Methods: Data from patients followed in a tertiary center with low-risk...

ea0084ps1-03-27 | Thyroid Cancer CLINICAL 1 | ETA2022

Clinical significance and prognosis of solid / trabecular component areas of papillary thyroid carcinoma

Pinheiro Sara , Damasio Ines , Simoes-Pereira Joana , Nunes da Silva Tiago , Leite Valeriano

Introduction: the presence of areas with a solid / trabecular growth pattern in differentiated papillary thyroid carcinoma (PTC) represents a source of controversy regarding clinical and prognostic significance and usually requires a more aggressive therapeutic approach. The aim of this study was to compare clinicopathological characteristics, treatments and prognosis of PTC with and without solid component (SC). We also aimed to evaluate whether SC affects patient outcome in ...