Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep168 | Calcium and Bone | ECE2023

Menses-associated decline of serum calcium in hypoparathyroid women

Mirnaya Svetlana

Some hypoparathyroid women report the appearance or intensification of hypocalcemia symptoms at the time of menses. It is still unknown whether this is the result of premenstrual syndrome or fluctuations in serum calcium levels. Studies have not found a relationship between fluctuations in levels of sex hormones and serum calcium and phosphorus and it appears probable that they affect neuromuscular excitability through a separate mechanism. Alterations in serum calcium levels ...

ea0041gp50 | Bone & Calcium Homeostasis (1) | ECE2016

Renal concentration capacity in primary hyperparathyroidism and changes after surgery and during medical management and monitoring

Mirnaya Svetlana , Mokrysheva Natalya

Introduction: Patients with primary hyperparathyroidism (pHPT) run an increased risk of death, and in some studies cardiovascular diseases were inversely related to urine osmolality.Aim: Evaluate the renal concentration capacity in patients with mild and severe pHPT, and its changes after surgery for pHPT and during medical management and monitoring.Materials and methods: The study included 77 patients (median age 57 (52;61)) with ...

ea0056p264 | Clinical case reports - Thyroid/Others | ECE2018

Functional hypoparathyroidism secondary to magnesium deficiency in long-term users of proton pump inhibitor: case report

Egshatyan Lilit , Mirnaya Svetlana

Introduction: Gastroesophageal reflux disease (GERD) is now widely prevalent around the world, with clear evidence of increasing prevalence in many developing countries. Treatment for most people with GERD includes lifestyle changes and medication. Proton pump inhibitors (PPIs) are a mainstay therapy for all gastric acid-related diseases. Long-term use of PPIs is associated with hypomagnesaemia, hypokalemia, hypocalcaemia, osteoporosis and bone fractures, renal disease, and ot...

ea0041gp44 | Bone & Calcium Homeostasis (1) | ECE2016

Diabetes mellitus and carbohydrate metabolism in primary hyperparathyroidism

Mokrysheva Natalya , Mirnaya Svetlana , Lipatenkova Anna

Introduction: Primary hyperparathyroidism (PHPT) results in alterations in carbohydrate metabolism, characterized by insulin resistance, hyperinsulinemia, and glucose intolerance.Objective: The aim of our study was to evaluate carbohydrate metabolism status in patients with PHPT.Methods: One hundred and nine patients with PHPT were investigated, healthy controls included 36 individuals matched by sex age and BMI (BMI=27±5 kg/m...

ea0063p102 | Calcium and Bone 1 | ECE2019

Various clinical features of Digeorge syndrome

Mokrysheva Natalia , Mirnaya Svetlana , Eremkina Anna , Dobreva Ekaterina , Bibik Ekaterina

Background: DiGeorge syndrome (DGS) is the rare genetic disorder caused by a 22q11.2 chromosome microdeletion. The main clinical features are associated with defective development of the pharyngeal pouch system and usually include congenital heart disease, hypoplasia of thymus resulting in immune deficiency and hypoparathyroidism. Also DGS patient has characteristic long face with narrow palpebral fissures, broad nasal bridge, micrognathia and small mouth, small dysmorphic ear...

ea0049ep257 | Calcium & Vitamin D metabolism | ECE2017

Normocalcemic versus Hypercalcemic Primary Hyperparathyroidism: a comparative study

Mokrysheva Natalya , Mirnaya Svetlana , Eremkina Anna , Krupinova Julia , Kovaleva Elena

Introduction: Normocalcemic primary hyperparathyroidism (NPHPT) is defined as a condition in which persistently normal serum calcium levels are observed in the presence of high levels of parathyroid hormone (PTH). NPHPT is a new entity which possibly represents a clinically symptomatic disease and which has generated a considerable scientific interest.Aim: To compare the clinical and laboratory data between the normocalcemic and hypercalcemic forms of PH...

ea0049ep318 | Clinical case reports - Thyroid/Others | ECE2017

Clinical case of atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures

Eremkina Anna , Mokrysheva Natalia , Krupinova Julia , Mirnaya Svetlana , Voronkova Iya

Introduction: Atypical parathyroid adenoma (APA) is rarely encountered cause of primary hyperparathyroidism (PHPT). No definite criteria are considered to distinguish preoperatively APA from parathyroid typical adenoma or carcinoma.The aimTo describe the clinical course of a patient with an atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures.Case presentation: A 61-year-old...

ea0049ep347 | Endocrine tumours and neoplasia | ECE2017

Recurrent ectopic parathyroid carcinoma

Krupinova Julia , Mokrysheva Natalia , Eremkina Anna , Pigarova Ekaterina , Mirnaya Svetlana

Background: In most cases of parathyroid carcinoma (PC) only recurrence could be a credible feature of malignancy.Clinical case: At the age of 19 years a woman was diagnosed with urolithiasis. At the age of 22 years she had a surgical resection of the neck nodule at the right site in the projection of carotid triangle. After the histological study, ectopic parathyroid tumor was misdiagnosis with paraganglioma (material is available for review). At the ag...

ea0070aep165 | Bone and Calcium | ECE2020

Primary hyperparathyroidism in multiple endocrine neoplasia type 1 (MEN-1) according to the online russian registry

Eremkina Anna , Mirnaya Svetlana , Maganeva Irina , Ajnetdinova Alina , Mokrysheva Natalia

Objective: Primary hyperparathyroidism (PHPT) is one of the most frequently diagnosed endocrine disorders. The Russian Registry of PHPT is an on-line web-based database with the aim to estimate the prevalence and main features of disease. PHPT in Multiple Endocrine Neoplasia type 1 (MEN-1) is associated with polyglandular and early involvement of parathyroid glands.Material and Methods: The database from The Russian Registry of PHPT was used for retrospe...

ea0026p545 | Bone/calcium/Vitamin D | ECE2011

Some epidemiological aspects of primary hyperparathyroidism in Russia

Rostomyan Liliya , Mokrysheva Natalya , Mirnaya Svetlana , Kirdyankina Nataliya , Rozhinskaya Liudmila

Primary hyperparathyroidism (PHPT) is the third most frequent endocrine disorder and has a variable clinical presentation. Asymptomatic PHPT became the predominant form of the disease with increase of itÂ’s incidence after the introduction of automated serum calcium measurement in North America and Europe. Data from Russia is lacking.Aim: To present the clinical profile of PHPT in Russia.Materials and methods: This retrospectiv...