Endocrine Abstracts

A young woman aged 23 years, with non-toxic goiter was treated in our Department. Serum levels of FT4, FT3 and TSH were within normal range, high resolution ultrasonography show very large glands (60 ml), with large nodule in left lobe and smaller one in the right lobe. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. Thyroid radioiodine scintigraphy showed homogenous and diffuse uptake in the right lobe, with very low uptake i...

Radioiodine therapy is non-invasive, safe and cost effective method of therapy for reduction of goitre. We aimed to determine whether radioiodine therapy has benefit effect on the symptoms mimicking hyperthyroidism in nontoxic goitre patients.Material and methods: We studied 20 patients with non toxic nodular goitre, aged 42–79 years, 12 females and 8 males. All the patients complained of some symptoms of hyperthyroidism (palpitation, hot intoleranc...

Objective: The aim of this study was to evaluate the influence of subclinical and overt hyperthyroidism on the chosen markers of endothelial function.Material and methods: The groups studied consisted of 97 hyperthyroid subjects (51 with subclinical and 46 with overt hyperthyroidism) and 39 healthy controls matched for age, gender and body mass index. The following parameters were measured: TSH, FT3, FT4 (by MEIA), VCAM-1 (vascular cell adhesion molecule...

Most of the patients with the benign cold nodule refuse surgical operation. Radioiodine therapy (RIT) is the choice for these patients. The aim of our study was to evaluate the efficacy of radioiodine therapy to reduce thyroid volume in patients with cold nodule by the use of two doses of radioiodine.Methods: We treated 40 patients with non-toxic nodular goitre with large cold nodule, aged 18 and 48 years; initial 24 h radioiodine uptake (RAIU) was range...

Introduction: The report describes the case of a late-diagnosed primary hyperparathyroidism in the patient, who developed catastrophic renal complications and such advanced osteoporosis, that hungry bone syndrome occurred after removal of parathyroid adenoma.Case report: A 63-year-old woman with long-lasting nephrolithiasis was admitted to the hospital due to high PTH discovered in a routine laboratory testing. She had undergone left-side nephrectomy 2 y...

The aim of our study was to assess the influence of radioiodine (131I) therapy on the achievement of euthyroidism, prevention of adverse effects on the cardiovascular and prevent evolvement to overt hyperthyroidism.Materials and methods: We treated 1600 patients refered to our department during the last 8 years, aged 23–77 years; 89% of them were females and 11% males; 520 patients with multinodular goitre (MNG), and 1080 patients with au...

We treated 4150 patients, aged 30–70 years; 1950 patient with toxic multinodular goitre (TMNG), and 2200 patient with autonomous toxic nodule (ATN). Qualification of these patients was based on high levels of serum fT3 and fT4, low levels of serum TSH. Malignant changes were excluded in all nodules by fine needle aspiration biopsy. All the patients had serum TSH levels ≤0.1 mU/l and the effective T-half was ≥3 days at the time of treatmen...

Oxidative stress plays an important role in hyperthyroidism-induced tissue damage. We aimed to determine whether radioiodine therapy has benefit effect on the oxidant and antioxidant status in patients with Graves’ Disease.Material and methods: We studied 30 patients with Graves’ disease, aged 18–48 years. 12 normal adult volunteers were studied as control group. All the patients were treated unsuccessfully by antithyroid drugs. The effect...

Aim: Clinical studies in Hashimoto thyroditis (HT) confirm, that even a minor thyroid dysfunction is related to significant changes in body mass. Betatrophin, also known as TD26/RIFL/lipasin/ANGPTL8/C19orf80, is a novel protein predominantly expressed in human liver and adipose tissue. Stimulators of betatrophin, such as thyroid hormones are usually relevant to energy expenditure or thermogenesis. The mechanisms of action of betatrophin are still unknown. In the present study ...

Introduction and aims: To date we have had some evidence that betatrophin is associated with insulin resistance. Some studies have demonstrated that betatrophin levels are elevated in type 2 diabetes, obesity and gestational diabetes. It has been shown that in mice betatrophin significantly improves beta cell function and glucose tolerance. This is the first study on betatrophin in which pregnant women were observed during all trimesters and in postpartum period to evaluate it...