Searchable abstracts of presentations at key conferences in endocrinology

ea0022p148 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Searching for the metabolic syndrome criteria in young adults with hypogonadism

Sonmez Alper , Haymana Cem , Bolu Erol , Tapan Serkan , Barcin Cem , Aydogdu Aydogan , Taslipinar Abdullah , Kutlu Mustafa

Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any c...

ea0022p162 | Cardiovascular endocrinology and lipid metabolism | ECE2010

The effect of testesterone replacement therapy on HDL subfraction levels in hypogonadotropic hypogonadism

Taslipinar Abdullah , Sonmez Y Alper , Bolu Erol , Tapan Serkan , Uckaya Gokhan , Aydogdu Aydogan , Kutlu Mustafa

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

ea0020p492 | Obesity and Metabolism | ECE2009

The influence of weight lose on immune system

Yazici Mahmut , Engin Gok Deniz , Pekel Aysel , Tapan Serkan , Sonmez Yusuf Alper , Musabak Ugur , Bolu Sinasi Erol , Kutlu Mustafa

Aim: The prevalence of overweight and obesity is increasing and becoming a global health problem. Obesity is the cause of increased cardiovascular morbidity and mortality and psychosocial problems. There are several reports which mentioning the unfavourable effects of aggressive weight loss regimes on the immune system. This study was designed to search for the effect of a straightforward, controlled and permanent weight loss program on the immune system.<p class="abstext"...

ea0041ep1087 | Thyroid cancer | ECE2016

Comparisons of Endothelial Dysfunction, Inflammation and Insulin Resistance in Differentiated Thyroid Cancer Patients According to Their Radioactive Iodine Treatment Status

Dinc Mustafa , Baskoy Kamil , Yildiz Ramazan , Tapan Serkan , Alagoz Engin , Yesildal Fatih , Ozturk Erkan , Taslipinar Abdullah , Aydogdu Aydogan , Deveci Salih , Arslan Nuri , Azal Omer , Sonmez Alper

Objective: Radioactive iodine (RAI) treatment has been reported to be associated to increased cardiovascular events and death compared to the general population, but the mechanism is not fully understood. Endothelial dysfunction, inflammation, and insulin resistance play important roles in the pathogenesis of atherosclerotic events. We aimed to compare papillary thyroid carcinoma patients receiving levothyroxine suppression therapy after bilateral total thyroidectomy with or w...

ea0032p186 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

The effect of testosterone replacement on endothelial dysfunction, inflammation and insulin resistance in male hypogonadotrophic hypogonadism

Sonmez Alper , Taslipinar Abdullah , Aydogdu Aydogan , Tapan Serkan , Meric Coskun , Basaran Yalcin , Sertoglu Erdim , Yilmaz Mahmut I , Serdar Muhittin A , Ozgurtas Taner , Bolu Erol , Kutlu Mustafa

Objective: Metabolic disorders are common in patients with hypogonadism. Testosterone replacement therapy (TRT) significantly improves symptoms of testosterone deprivation such as mood, libido or musculoscelatal power. However, whether the metabolic and cardiovascular risk is improved is not clearly known. We aimed to search for the metabolic and cardiovascular effects of TRT.Design: Prospective study, performed in the outpatient units of Gulhane Medical...

ea0032p193 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

HDL cholesterol subfractions and the effect of testosterone replacement in hypogonadism

Bolu Erol , Sonmez Alper , Tapan Serkan , Taslipinar Abdullah , Aydogdu Aydogan , Meric Coskun , Basaran Yalcin , Uckaya Gokhan , Serdar Muhittin A , Kurt Ismail , Azal Omer

Metabolic disorders and cardiovascular events are increased in hypogonadism. Serum HDL composition is a better cardiovascular predictor than the HDL counts. However, there is no information about the HDL subfractions in patients with hypogonadism. We designed a prospective study to investigate the HDL subfractions in treatment naïve subjects with hypogonadism and the effects of two different testosterone replacement regimens on the HDL subfractions. Seventy young male pat...

ea0022p327 | Diabetes | ECE2010

Chitotriosidase activity predicts endothelial dysfunction in type 2 diabetes mellitus

Haymana Cem , Sonmez Alper , Tapan Serkan , Safer Umut , Celebi Gurkan , Ozturk Ozlem , Genc Halil , Dogru Teoman , Tasci Ilker , Erdem Gokhan , Taslipinar Abdullah , Aydogdu Aydogan , Yilmaz Mahmut I , Kurt Ismail , Kutlu Mustafa

The enzyme chitotriosidase (ChT) is secreted by activated macrophages and play active role in human immune response. ChT activity is increased in atherosclerosis in association to the extent of the disease. We investigated the relevance of ChT to endothelial functions and insulin resistance in patients with T2DM.Forty newly diagnosed and untreated patients with T2DM (male 17; age: 47.0±6.2 years) and 50 healthy volunteers (male 21; age: 50.2±8....