Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep651 | Endocrine tumours and neoplasia | ECE2016

Hirsutism with rapid onset presenting in a 62-year-old postmenopausal woman

Tzaves Ioannis , Papadakis Georgios , Moustakas Konstantinos , Keramidas Ioannis , Kaltzidou Victoria , Veniou Eirini , Kalinoglou Nikolaos , Tertipi Athanasia

Introduction: Virilizing tumors are rare, but frequent cause of virilization in postmenopausal women.Case report: A 62-year-old postmenopausal woman presented with a rapid onset of hirsutism with increased terminal hair growth, particular on chin and abdomen, frontal male pattern balding in the last 5 months. Physical examination revealed a low-pitched, deepened voice and clitoromegaly. The Ferriman–Gallwey score was 18. Laboratory evaluation: Testo...

ea0020p323 | Clinical case reports and clinical reports | ECE2009

Treatment of a case of metastatic thyroid cancer with sorafenib

Kaldrymides Philippos , Kostoglou-Athanassiou Ifigenia , Goudouvas Anastasios , Thomas Dimitrios , Tertipi Athanasia , Ziras Nikolaos

Although the prognosis of thyroid cancer is in general quite favorable when standard management paradigms are applied, some patients do much less well. Radioactive iodine refractory, recurrent or metastatic disease is prognostically more worrisome. Sorafenib, a multitargeted small molecule kinase inhibitor, including the VEGF receptor and BRAF kinase, has been evaluated in patients with thyroid cancer. The aim of the study was to present a case of metastatic thyroid cancer and...

ea0020p528 | Paediatric Endocrinology | ECE2009

Childhood obesity and bone age

Petrou Vassilios , Tertipi Athanasia , Georgoulas Thomas , Papastathi Eleni , Deligeorgi Maria , Skarpa Vassiliki , Papathanasiou Asteroula

Obese children frequently present with accelerated growth and early puberty.Objective: To examine the degree of bone maturation in children with simple obesity.Patients and methods: One hundred eighteen boys with mean chronological age (CA) 9.9±2.2 years (3–13 years) and 102 girls with CA 8.4±2.0 years (3–12 years) with simple obesity (BMI>97th centile for age and sex) were studied. Ninety-five children were...

ea0016p112 | Clinical cases | ECE2008

Children with growth retardation due to Rathke cleft cyst

Petrou Vassilios , Papachilleos Petros , Valvis Nikolaos , Ioannidis Dimitrios , Tertipi Athanasia , Georgoulas Thomas , Chadjiathanasiou Charalambos , Papathanasiou Asteroula

Rathke cleft cysts (RCCs) are non-neoplastic sellar lesions derived from remnants of Rathke’s pouch, and mostly asymptomatic. Symptomatic RCCs occur usually in middle-age, are >1 cm, and cause pituitary hypofunction, diabetes insipidus, hyperprolactinemia or visual impairment. In children, RCCs are rare and usually asymptomatic. However, symptomatic cases may present with growth retardation and diabetes insipidus. We report two children with symptomatic RCC manifestin...

ea0016p299 | Endocrine tumours | ECE2008

Adrenal ganglioneuroma: a new cause of increased serum calcitonin

Bakola Theodosia , Gkountouvas Anastasios , Aggelopoulou Anastasia , Tertipi Athanasia , Pappas Anastasios , Iakovidou Ioanna , Nisiotis Athanasios , Kaldrimidis Philippos

Introduction: Ganglioneuromas are rare, benign tumors of mature ganglion cells, arising from the sympathetic ganglia and 20% are located in the adrenal medulla, representing 1–4% of adrenal incidentalomas. About 1/3 secrete catecholamines but hypertension and other adrenergic symptoms are rare. About 60% are depicted with 131I- MIBG.Case report: A 72-year-old man was admitted for a left adrenal tumor 9×8 cm, incidentally found in abd...

ea0016p725 | Thyroid | ECE2008

Treatment with thyroxine reduces thyroid volume in euthyroid children with Hashimoto thyroiditis

Scarpa Vasiliki , Kousta Eleni , Tertipi Athanasia , Ioannidis Dimitris , Petrou Vasilis , Chatziathanasiou Charalambos , Papathanasiou Asteroula

Introduction: There is no concensus whether euthyroid children with Hashimoto’s thyroiditis (HT) need treatment with thyroxine.Aim of the study: To assess whether thyroxine influences goitre progression (calculated thyroid volume on U/S scan) in euthyroid children with HT.Subjects and methods: We studied 50 euthyroid children with HT for a 2-year period. Children with a multinodular goitre were not included in the study. Twent...

ea0014p441 | (1) | ECE2007

An 8-year-old boy with seizures and hypokalemia due to a paraganglioma

Petrou Vassilios , George Kolofotis , Georgouli Eleni , Papathanasiou Asteroula , Athanasia Tertipi , Stefanidis Constantinos , Hadjiathanasiou Charalambos

Pheochromocytomas and paragangliomas, tumors originating from the chromaffin cells, are rare in children.We report an 8-year-old boy who was admitted to the intensive care unit with seizures for which the child had to be intubated, severe hypokalemia (1.8 mEq/l), hyponatremia (127 mEq/l) and fever. Parents reported that several months before admission the boy had nocturnal sweating. Brain MRI revealed areas of increased sign intensity in the parietal lob...

ea0041ep251 | Clinical case reports - Pituitary/Adrenal | ECE2016

21-hydroxylase deficiency presenting as bilateral adrenal masses in the sixth decade of life in a phenotypically male but genetically female patient

Panagiotidi Evgenia , Papadakis Georgios , Manitarou Paraskevi , Tzaves Ioannis , Triantafillou Eleni , Kalaitzidou Styliani , Sapera Aggeliki , Katsoulis Konstantinos , Kaltzidou Victoria , Tertipi Athanasia

Introduction: 21-hydroxylase deficiency (21-OHD) is a common inherited disorder accounting for 90–95% of congenital adrenal hyperplasia (CAH) cases. Some cases may be diagnosed in adulthood after the incidental discovery of adrenal masses on computerized tomography (CT).Case report: A 59-year-old male was investigated for incidentally discovered bilateral adrenal masses in an abdomen CT scan, measuring 5 cm on the right and 8 cm on the left adrenal....

ea0037ep846 | Thyroid cancer | ECE2015

Association of calcium-stimulated calcitonin values with pathological findings following total thyroidectomy

Papadakis Georgios , Keramidas Ioannis , Triantafillou Eleni , Kanouta Foteini , Pappa Theodora , Kaltzidou Victoria , Tertipi Athanasia , Vecchini Gino , Papadouli Despoina , Pappas Anastasios

Background and objectives: Medullary thyroid carcinoma (MTC) originates from thyroid C-cells and is a calcitonin (CT) secreting tumour with aggressive behaviour. Surgery is recommended in all patients with basal or calcium-stimulated CT values of 100 pg/ml or higher due to the high probability of MTC. The objective of this study was to investigate the utility of calcium stimulation test for CT in order to distinguish MTC from C-cell Hyperplasia (CCH) preoperatively and to exam...

ea0037ep848 | Thyroid cancer | ECE2015

False-positive uptake of radioiodine WBS in a patient with papillary thyroid cancer due to a vertebral hemangioma

Triantafillou Eleni , Kanouta Foteini , Papadakis Georgios , Tzaves Ioannis , Panagiotidi Evgenia , Trivizaki Erasmia , Kaltzidou Victoria , Tertipi Athanasia , Drosou Aspasia , Pappas Anastasios

Introduction: Diagnostic and post-therapy radioiodine whole body scan (WBS) is used in the follow-up of differentiated thyroid carcinoma (DTC) for the detection of local recurrence or remote metastasis. We report a case of false-positive uptake of radioiodine WBS.Case report: A 37-year-old female patient underwent subtotal thyroidectomy for multinodular goitre and histology revealed multifocal papillary thyroid carcinoma, of follicular type with three fo...