Searchable abstracts of presentations at key conferences in endocrinology

ea0065op4.1 | Bone and Calcium | SFEBES2019

Oral calcium loading test can predict the progression of hypercalcaemic primary hyperparathyroidism in patients with normocalcaemic hyperparathyroidism

Oungpasuk Kanapath , Hadjiminas Demetrios , Tolley Neil , Robinson Stephen , Cox Jeremy

Introduction: Normocalcaemic hyperparathyroidism (nHPT) is a persistently elevated parathyroid hormone (PTH) with normal ionised calcium levels in the absence of secondary hyperparathyroidism. nHPT is proposed to be an earlier phase of hypercalcaemic primary hyperparathyroidism (PHPT). nHPT patients can present with progressive complications such as osteoporosis and nephrolithiasis. Currently, there is no diagnostic test to confirm primary hyperparathyroidism in nHPT patients,...

ea0081p505 | Late-Breaking | ECE2022

Primary hyperparathyroidism, familial hypocalciuric hypercalcaemia or both?

Kapoor Ashutosh , Sharma Bhavna , Sriranganathan Danujan , Tolley Neil , Dimarco Aimee , Rahman Mushtaqur

Introduction: Primary hyperparathyroidism (PHPT) is an endocrine condition in which autonomous excessive secretion of parathyroid hormone (PTH) results in hypercalcaemia. In approximately 80% of cases the aetiology is due to a single parathyroid adenoma, the remainder are due to hyperplasia of more than one gland. Familial Hypocalciuric Hypercalcaemia (FHH) is an autosomal dominant, inactivating mutation of the calcium-sensing receptor, causing a right-shift in the concentrati...

ea0021p219 | Endocrine tumours and neoplasia | SFEBES2009

MEN2B patients with a RET A883F mutation have less aggressive MTC than those with the common RET M918T mutation

Worth Gabriella , Palazzo Fausto , Tolley Neil , Robinson Stephen , Cox Jeremy , Williams Graham , Bassett Duncan

MEN2B is the most aggressive form of MEN2. Consequently, the new American Thyroid Association guidelines recommend prophylactic thyroidectomy early in the first year of life. Ninety-seven percentage of MEN2B cases result from a germline methionine to threonine mutation at codon 918 (M918T) of the RET proto-oncogene. In addition, an exceedingly rare alanine to phenylalanine mutation at codon 883 (A883F) has been reported in 4 unrelated adults. In each case metastatic MTC and th...

ea0073aep662 | Thyroid | ECE2021

An audit of thyroidectomy in Graves’ Disease, in a large UK tertiary centre

Jones Larissa , Khan Shaila , Tolley Neil , Palazzo Fausto , Cox Jeremy , Agha-Jaffar Rochan , Robinson Stephen

BackgroundThyrotoxicosis with GravesÂ’ Disease is treated with thionamide, radio-iodine treatment and thyroidectomy. Surgery is an important choice, especially when GravesÂ’ Disease is complicated by thyroid orbitopathy. Pre- and post-operative protocols for thyroidectomy are imperative.Aims1) To assess pre-operative preparation of patients, with potassium iodide, vitamin D, beta blockade, and the pre...

ea0094op4.1 | Thyroid | SFEBES2023

Management of thyroid nodules in patient with phosphatase and tensin homolog gene (PTEN) mutation

Yang Wei , Palazzo Fausto , Tolley Neil , Dimarco Aimee , Brady Angela , Tan Tricia

Introduction: Phosphatase and tensin homolog gene (PTEN) gene encodes a lipid phosphatase that plays a central role in cell-cycle processes. PTEN hamartoma tumour syndrome (PHTS), caused by the mutation of the PTEN gene, is a diverse multi-system disorder. PHTS is characterised by the hamartomatous growths, increased risk of breast, thyroid, and renal cancers. In terms of thyroid presentation of PHTS, there is up to 75% risk of multinodular goitre and the life...

ea0059p208 | Thyroid | SFEBES2018

Clinico-pathological correlation of U3 thyroid nodules: A retrospective review

Ellatif Mostafa , Idowu Oluwagbemiga , Khalid Neelam , Darko Daniel , Lingam Ravi , Tran Tan , Tolley Neil , Khatri Pushpa , Muralidhara Koteshwara

Background: The incidence of thyroid cancer is increasing globally mainly due to increased detection of papillary microcarcinoma. The British Thyroid Association (BTA) guideline (2014) recommends the use of U1-U5 classification on ultrasound to assess thyroid cancer risk. U3 nodules have low, but indeterminate risk and therefore need FNAC. This retrospective review analyses the outcome of U3 nodules in an outer London hospital.Methods: Thyroid ultrasound...

ea0025p318 | Thyroid | SFEBES2011

Serum phosphate predicts temporary hypocalcaemia following thyroidectomy

Sam Amir H , Dhillo Waljit S , Donaldson Mandy , Moolla Ahmad , Meeran Karim , Tolley Neil S , Palazzo Fausto

Background: Temporary hypocalcaemia occurs in up to 40% of patients following a total thyroidectomy. Serum calcium and parathyroid hormone (PTH) measurements are currently used to predict post-thyroidectomy hypocalcaemia. However, immediate access to PTH measurement is expensive and not widely available. Serum phosphate responds rapidly to changes in circulating PTH levels and its measurement is readily available in all hospitals. We evaluated the use of serum phosphate to pre...

ea0077p162 | Bone and Calcium | SFEBES2021

Undiagnosed probable genetic primary hyperparathyroidism presenting with brown tumors and deafness

Sharma Bhavna , Qureshi Asjid , Rahman Mushtaqar , Tolley Neil , Thakker Rajesh , Hui Elaine , Seechurn Shivshankar , Remedios Denis , Seetho Ian , Deore Mahesh , Mantega Michele , Mateen Abdul

A 25 year old Afghan male presented with a 4 day history of worsening left-sided loin pain. He had a past history of deafness since birth, speech problems and development delay. Bilateral renal calculi and widespread multiple well defined lytic lesions (likely brown tumours) were seen on CT-KUB. The corrected calcium was 3.21 mmols/l, PTH 80 pmol/l, Vitamin D 25 nmol/l, phosphate 0.49 mmols/l, ALP 960 IU/l and fractional calcium excretion was 0.16. His skull X Ray/OPG, done du...

ea0094oc7.5 | Thyroid | SFEBES2023

Thyroid cancer referral pathways: findings from an inner-city tertiary thyroid centre

Singh Ainesh , Agha-Jaffar Rochan , Cox Jeremy , Madani Gitta , Bhatia Kunwar , Moonim Mufaddal , Wernig Florian , Di Marco Aimee , Palazzo Fausto , Robinson Stephen , Tolley Neil

Background: Absence of effective clinical indicators for thyroid cancer, which has an excellent prognosis, means community ultrasounds (US) can be important in identifying risk. Where cytology is definitive it should be reviewed by appropriate MDT specialists. This study aimed to examine the outcomes from two-week-wait (2WW) referrals.Methods: To achieve these aims, we retrospectively reviewed 293 patients referred on th...