Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep348 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Modified Appleby Procedure in the Treatment of Pancreatic Neoplasms

Torres Susana

Introduction: Pancreatic neoplasms portray the 12th most prevalent neoplasm worldwide, determining a five-year survival of only 5 to 10% including all stages. Despite tumoral aggressiveness, the modified Appleby procedure can be performed in selected patients, representing a curable alternative in borderline-resectable or locally advanced pancreatic tumors’ treatment in the context of a multimodal practice. Objectives: This work aims to review the state of the art regardi...

ea0020s5.4 | IGF1 survival, proliferation and cancer | ECE2009

IGF-I and neuroprotection

Aleman Ignacio Torres

Neuroprotection defines a set of homeostatic, self-repair mechanisms that probably evolved for the specially demanding conditions imposed by brain function. Among these, intercellular messengers such as the insulin-like growth factors (IGFs), that appeared very early during phylogeny, apparently play a prominent role despite their peripheral origin. In contrast to the heterogeneity seen in primitive organisms where at least 30 different IGF-like peptides are described, in mamm...

ea0035p312 | Clinical case reports Thyroid/Others | ECE2014

Diagnosis of neonatal diabetes mellitus in the mother through the detection of hyperglycemia in her child

Torres Isabel , Santos M Angeles , Castano Luis

Introduction: Neonatal diabetes mellitus (NDM) is a rare disease diagnosed within the first months of life that is usually permanent in 50% of cases. Heterozygous mutations of KCNJ11 and ABCC8 genes encoding the two Kir6.2 and SUR1 subunits of the b-cell ATP-dependent potassium channel have been associated with NDM, which is characterized by a successful response to sulfonylureas.Case report: We present a 32-year-old woman diagnosed wit...

ea0022p92 | Bone/Calcium | ECE2010

Management of primary hyperparathyroidism in Spain: a national survey

Torres Manuel Munoz , on behalf of Calcium Study Group

Background: At the Third International Workshop on asymptomatic primary hyperparathyroidism (PHPT), recent data on the disease were reviewed, but limited information of the PHPT management in Europe is available.Methods: We performed an online questionnaire survey in hospital endocrinology services to determine knowledge of current PHPT recommendations and its management in the clinical practice during 2009 Spain.Results: Ninety-ni...

ea0070aep537 | Endocrine-related Cancer | ECE2020

Pheochromocytoma due to TMEM127 mutation – the importance of genetic test for clinical decision

Paredes Silvia , Lopes Sara , Torres Isabel , Alves Marta

Background: Catecholamine-secreting tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic ganglia are respectively referred to as pheochromocytomas and paragangliomas. The classic triad of symptoms in patients with pheochromocytoma (PHEO)consists of episodic headache, sweating, and tachycardia. Approximately one-half have paroxysmal hypertension; the rest have either primary hypertension or normal blood pressure. Clinicians should always consider P...

ea0070aep808 | Reproductive and Developmental Endocrinology | ECE2020

Androgen receptor inhibition by 4, 4’ DDE is reduced by mutations in the BF3 site

Lozano Andrea , Torres Justo , Resto Tahyra , Dean Frank

Androgen receptor (AR) is an important target for inhibition by some endocrine disrupting chemicals. Some diphenyl compounds inhibit AR activity by binding to a hydrophobic surface binding site, BF3. A similar diphenyl structure is found in 4.4’ DDT and its breakdown product 4.4’ DDE. Previous results showed that DDT, DDE, and related compounds induced the release of bound dihydrotestosterone from the AR ligand binding domain with IC50 values ranging fro...

ea0029p1341 | Pituitary Basic | ICEECE2012

Effect of estrogen and FGF-2 interaction on lactotroph cell proliferation mediated by membrane-initiated signaling

Sosa L. , Gutierrez S. , Petiti J. , Vaca A. , De Paul A. , Torres A.

Estradiol (E2) may directly interact with growth factors stimulating cell proliferation and differentiation. Previously, we have demonstrated that E2 through membrane estrogen receptor α (mERα) modulates the lactotroph cell population which exhibit noticeable changes in the pituitary gland. The aim of this study was to analyze the mERα contribution on lactotroph cell proliferation in response to E2 and FGF-2 interaction evaluatin...

ea0029p1827 | Thyroid cancer | ICEECE2012

Follicular Neoplasms: Clinical, Sonographic and Cytological Determinants and its Histological Correlation

Couto J. , Martins R. , Santos A. , Monteiro P. , Torres I.

Introduction: Fine-needle biopsy(FNB) is an essential diagnostic tool in the evaluation of thyroid nodules, however, follicular neoplasm(FN) does not exclude malignancy. Some sonographic and cytological features have been described as being associated with increased risk of malignancy. The authors aimed to identify demographic, sonographic and cytologic features associated with malignancy in patients with a cytological diagnosis of FN.Methods: Descriptiv...

ea0026p646 | Clinical case reports | ECE2011

Diabetes insipidus in a patient with breast carcinoma

Couto J , Santos A P , Martins R , Giesteira L , Torres I

Introduction: Central diabetes insipidus (CDI) is characterized by a deficient secretion of anti-diuretic hormone (ADH), in which a large volume of hypotonic urine is eliminated. Pituitary metastatic disease is rare, accounting for 1% of all excised pituitary tumors and generally involves the posterior pituitary. Neoplasms that more often originate pituitary metastases are breast and lung cancer. Breast cancer (BC) is associated with pituitary secondary involvement in 5.3 to 2...

ea0090p762 | Thyroid | ECE2023

Assesmement of An Artificial Intelligence-Based Decision Support System in The Thyroid Nodule Evaluation in Clinical Practice

Fernandez Velasco Pablo , Torres Torres Beatriz , Perez Lopez Paloma , Benito-Sendin Plaar Katia , De Luis Roman Daniel , Diaz Soto Gonzalo

Objective: To evaluate the impact of a decision support system (DSS) based on artificial intelligence (AI) -KoiosDS- on ultrasound (US) image analysis and risk stratification in thyroid nodules. Material and methods Retrospective US study of all thyroid nodules with histologic (AP) result from June 2020 to December 2021. Diagnostic performance of US with ACR-TIRADS, by four endocrinologists and DSS, before and after the use of AI was evaluated.Results: A...