Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp21 | Adrenal (2) | ECE2016

Clinical characteristics and tumour size evolution in patients with bilateral adrenal tumours

Galoiu Simona , Pena Raluca , Trifanescu Raluca , Niculescu Dan Alexandru , Dumitrascu Anda , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...

ea0022p853 | Thyroid | ECE2010

Marked sensitivity of pituitary feedback to levothyroxine in asymptomatic primary autoimmune hypothyroidism

Trifanescu Raluca-Alexandra , Coculescu Mihail

Background: Few cases of hypersensitivity of thyroid–pituitary feedback in hypothyroid children were reported.Aim: To present a family with asymptomatic, severe biochemical primary autoimmune hypothyroidism who showed a marked sensitivity of pituitary feedback to levothyroxine treatment.Methods: TSH was measured by 3rd generation immunoassay kit.Case report: R.G, woman, aged 22, presented for asymptomati...

ea0037ep289 | Calcium and Vitamin D metabolism | ECE2015

Glucocorticoid induced osteoporosis: can we do more to prevent it?

Cristina Plaisanu , Vasilia Iorgoveanu , Raluca Trifanescu

Introduction: Osteoporosis is a well-known and extremely debated side effect of glucocorticoid therapy being able to generate vertebral fractures even at low doses. Our study highlights the need for better prevention through improved doctor-patient communication and correct implementation of available screening tools.Methods: Since August–December 2014 we distributed to 85 rheumatic patients a self-compiled questionnaire. We recorded patient data an...

ea0020p88 | Thyroid | ECE2009

What is the outcome of combined therapies in amiodarone-induced thyrotoxicosis?

Trifanescu Raluca-Alexandra , Ursu Horea , Purice Mariana

Objective: To assess the outcome of medical and ablative therapies in amiodarone-induced thyrotoxicosis (AIT).Subjects and methods: Seventy patients (32 M/38 F, aged 59.7±1.4 years) with AIT (24-type 1, 20-type 2 and 26-mixed forms) were followed-up 13.4±2.3 months. TSH was measured by immunoradiometric assay, TT3 and TT4 by chemiluminescence.Results: Antithyroid drugs (ATD) were used as single thera...

ea0086p254 | Neuroendocrinology and Pituitary | SFEBES2022

Prevalence of cancer in a cohort of acromegaly patients

Trifanescu Raluca , Toma Iustin , Dumitrascu Anda , Goldstein Andrei , Poiana Catalina

Background: Growth hormone directly stimulates tumour growth, angiogenesis and metastasis through autocrine and paracrine effects on cancer cells, while through IGF1 inhibits apoptosis and promotes epithelial proliferation. Although disputed, some studies have shown an increased cancer incidence in acromegaly patients, especially in uncontrolled subjects, while others have not.Aim: To assess prevalence of cancer in a cohort of patients with long term tre...

ea0086p259 | Neuroendocrinology and Pituitary | SFEBES2022

Successful use of recombinant human TSH prior to radioiodine therapy in an acromegaly patient with differentiated thyroid cancer and pituitary insufficiency

Toma Iustin , Trifanescu Raluca , Goldstein Andrei , Dumitrascu Anda , Poiana Catalina

Background: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. Standard treatment includes thyroidectomy (extention depending on tumour size, pathology and lymph nodes involvement). If indicated, radioiodine therapy after TSH stimulation either by levothyroxine withdrawal or rhTSH administration is recommended. In patients with thyrotropin deficiency rhTSH administration is mandatory.Case report: A 30-year-old woman, resident in...

ea0044p228 | Reproduction | SFEBES2016

Causes of primary amenorrhea in women evaluated in an academic center of adult endocrinology

Gheorghiu Monica Livia , Cucu Constantin , Trifanescu Raluca Alexandra , Badiu Corin

Introduction: Primary amenorrhea is defined as the absence of menses at age 15 years in the presence of normal growth and secondary sexual characteristics, or at 13 years, if there is no breast development. We retrospectively assessed the causes of primary amenorrhea in a series from an academic center of adult endocrinology.Patients and methods: We retrieved data from the files of 111 consecutive patients with primary amenorrhea evaluated in our center ...

ea0038p162 | Neoplasia, cancer and late effects | SFEBES2015

Outcome of insulinomas diagnosed in a tertiary endocrine centre

Trifanescu Raluca , Baciu Ionela , Gheorghiu Monica , Dumitrascu Anda , Poiana Catalina

Background: Insulinomas, the most common functional neuroendocrine tumours of the pancreas, are usually sporadic, benign and solitary.Aims: To assess biochemical data, localisation and treatment outcome of insulinomas diagnosed in a tertiary endocrine centre.Patients and methods: Twenty-five patients (14 F/11 M), aged 49.1±14.1 years, diagnosed with insulinoma in a Neuroendocrine Tumours centre between 2000 and 2014 were retro...

ea0035p92 | Bone and Osteoporosis | ECE2014

Increased osteoporotic fractures' risk in elderly patients with lower sodium levels

Trifanescu Raluca , Carsote Mara , Soare Dan , Poiana Catalina

Background: Low serum sodium levels were associated both in experimental studies and in clinical practice with increased prevalence of osteoporosis, due to decreased bone mineralization and increased osteoclastic activity. On the other hand, hyponatremia – independent of osteoporosis – is associated with fracture occurrence.Objectives: To assess the relationship between serum sodium levels and osteoporotic fractures.Patie...

ea0032p326 | Clinical case reports - Thyroid / Others | ECE2013

Radiation-induced primary hypothyroidism in patients with head and neck cancer

Trifanescu Raluca , Ion Oana , Carsote Mara , Poiana Catalina

Background: Hypothyroidism is a frequent side effect of external radiotherapy of the cervical region for head and neck cancer. Up to 33% of irradiated patients developed primary hypothyroidism within 2 years after radiation therapy. The risk of hypothyroidism increases with radiation dose.Patients and methods: Four patients (2M/2F), aged 53.3±13.9 years, resident both in iodine sufficient (n=2) and iodine deficient areas (n=2), wer...