Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep540 | Diabetes therapy | ECE2016

Impact of obesity on management of type 2 diabetes

Cheah Seong Keat , Duane Catherine , Durak Abigail , Sreenan Seamus , McDermott John , Tun Tommy Kyaw

Management of type-2 diabetes (T2D) should be individualised given recent increase in treatment options. There is a spectrum of phenotype of T2D from thinner patients who may be more insulin deficient to those who are overweight/obese and insulin resistant. We hypothesized that, if we are personalising treatment, thinner patients would be more likely to be treated with insulin secretagogues. To compare the management between these phenotypes, we reviewed 1007 patients with T2D...

ea0015p160 | Diabetes, metabolism and cardiovascular | SFEBES2008

Independent effects of insulin resistance and high molecular weight adiponectin on HDL cholesterol in polycystic ovarian syndrome

Phelan Niamh , O'Connor Annalouise , Tun Tommy Kway , Correia Neuman , Roche Helen , Boran Gerard , Gibney James

There is an increase in cardiovascular risk factors in polycystic ovarian syndrome (PCOS) compared with BMI matched controls. Almost all women with PCOS are insulin resistant and increased cardiovascular risk is commonly attributed to insulin resistance (IR). However, it is unclear if cardiovascular risk differs in women with PCOS compared to equally insulin resistant women. We performed a case–control study (n=56 pairs) of women with PCOS (NIH criteria) compared t...

ea0013p256 | Reproduction | SFEBES2007

Differential causes of hypertriglyceridaemia and low HDL-cholesterol in women with polycystic ovary syndrome

Tun Tommy Kyaw , Correia Neuman , Phelan Niamh , Roche Helen , Boran Gerard , Gibney James

Women with polycystic ovary syndrome (PCOS) have an increased prevalence of cardiovascular risk factors. Insulin resistance (IR) is believed to be an important factor in the pathogenesis of both PCOS and cardiovascular disease and thus provides a plausible link between these two conditions. An exaggerated post-prandial triglyceride (TG) response is thought to be one of the mechanisms through which IR is associated with atherosclerosis. The aim of this study was to compare fast...

ea0073aep750 | Thyroid | ECE2021

Increasing levothyroxine requirements in a patient with previously stable hypothyroidism

Batool Maria , Cadogen Sinead , Kyaw Tun Tommy , Sreenan Seamus , Denton Mark , Mcdermott John

A 44 year old woman presented with leg swelling. Past history included hypothyroidism and ulcerative colitis treated with eltroxin (100 mg/day) and azathioprine (100 mg/day) respectively. Clinical examination revealed pitting oedema to knees and a ’puffy face’. Free T4 was 5.8 pmol/l (12–22 pmol/l), TSH 84.61 mU/l (0.27–4.20), serum albumin 24 g/l (40–49 g/l). She reported good compliance with L-thyroxine and no recent gastrointestinal symptoms. L-thyr...

ea0073ep67 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Boerhaave syndome and ’Diabetic Ketoalkalosis’ in a patient with type 1 diabetes mellitus: a case report

Batool Maria , Ni Chinneide Ashling , Tudor Roxana , Kyaw Tun Tommy , Sreenan Seamus , Arumugasamy Mayilone , McDermott John

A 20-year-old woman, with type 1 diabetes, presented to Emergency Department complaining of abdominal pain and vomiting for 3 days. She reported intermittent non-compliance with insulin therapy. Physical examination revealed epigastric tenderness. Blood glucose was 34.6 mmol/l, blood ketones 7.8 mmol/l, creatinine 131 µmol/l and CRP 31.47 mg/l (< 10). Despite clinical and initial laboratory features suggesting diabetic ketoacidosis, pH was 7.52 (7.32–7.43), pCO<s...

ea0013p333 | Thyroid | SFEBES2007

Neuropsychological abnormalities in overt and sub-clinical hypothyroidism improve but do not normalise following 3 months replacement with L-thyroxine

Correia Neuman , Mullally Sinead , Tun Tommy Kyaw , Phelan Niamh , Fitzgibbon Maria , O’Mara Shane , Boran Gerard , Gibney James

The neuropsychological mechanism underlying cognitive impairment in hypothyroidism is poorly understood. It is not known whether cognitive impairment resolves following L-Thyroxine (LT4) replacement. It is also unknown whether similar neuropsychological abnormalities occur in patients with sub-clinical hypothyroidism (SCH). To address these questions, we performed neuropsychological tests in 17 patients with hypothyroidism (age 45±3 years; mean±S.E.M.)...

ea0041ep1122 | Thyroid cancer | ECE2016

A study on age and nodule size in affecting decision for repeat thyroid FNAC after one benign cytology

Keat Cheah Seong , Pierce Brian , Kumar Anusha , Kyaw Tun Tommy , Sreenan Seamus , McDermott John , Hickey Neil , Leen Eamon , Sabah Muna , Walsh Thomas

Introduction: Fine needle aspiration cytology (FNAC) is a widely adopted pre-operative investigatory tool for thyroid nodules. The British Thyroid Association (BTA) recently updated guidelines recommending that an FNAC that initially yields benign cytology (Thy2) should be repeated if there is any clinical or ultrasound (US) suspicion (1). We postulate that there is a tendency for a more conservative approach in older age groups with smaller thyroid nodules on US studies.<...

ea0015p352 | Thyroid | SFEBES2008

Hippocampal memory deficits in hypothyroidism

Correia Neuman , Mullaly Sinead , Cooke Gillian , Tun Tommy Kyaw , Phelan Niamh , Feeney Joanne , Fitzgibbon Maria , O'Mara Shane , Boran Gerard , Gibney James

Memory formation largely depends on normal function of the temporal lobes (particularly the hippocampal complex) and prefrontal cortex. Evidence from animal studies suggests abnormal hippocampal function in hypothyroidism1. We hypothesized that specific defects in hippocampal-dependent memory would be observed in hypothyroid patients. Patients with overt (n=17) and subclinical (n=17) hypothyroidism underwent neuropsychological testing at baseline, 3 an...

ea0037ep759 | Pituitary: clinical | ECE2015

Alterations in thyroid hormone levels following GH replacement exert complex biological effects

Glynn Nigel , Kenny Helena , Salim Tarik , Halsall David J , Boran Gerard , Cook Paul , Smith Diarmuid , Tun Tommy , McDermott John H , Tormey William , Thompson Chris J , McAdam Brendan , O'Gorman Donal , Agha Amar

Introduction: Alterations in the hypothalamic–pituitary–thyroid axis have been reported following GH replacement, with a decline in circulating T4 concentration the most consistent finding. However, the clinical significance of GH-induced alterations in circulating levels of thyroid hormone is unclear.Aim: To examine the relationship between changes in serum concentration of thyroid hormones and known biological markers of thyroid ho...