Searchable abstracts of presentations at key conferences in endocrinology

ea0063p743 | Thyroid 2 | ECE2019

The prevalence of anti-parietal cell and tissue-transglutaminase antibodies in patients with autoimmune thyroid disease: a preliminary report

Rosenblum Rachel Chava , Rotman-Pikielny Pnina , Shapiro Menachem , Twito Orit

Background: The association between autoimmune thyroid disease (AITD) and other autoimmune diseases is well-known. The prevalence of concurrent autoimmune gastritis and celiac disease in AITD has been estimated at approximately 20–25% and 2–5% respectively. Although both conditions have significant morbidity including malignancy and may necessitate dietary modifications and endoscopic evaluation, no recommendation exists to screen AITD patients for these autoimmune d...

ea0073aep242 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Post hip-fracture rehabilitation outcomes of diabetic and non-diabetic elderly patients

Ben-Joseph Ronen , luboshitz Barak , Heffez-Ayzenfeld Rachel , Twito Orit

BackgroundAlthough patients with diabetes mellitus (DM) are at higher risk of hip fracture, data regarding the effect of DM on rehabilitation outcomes is limited.MethodsA retrospective population-based study was conducted comparing diabetic and non-diabetic elderly patients with a recent hip fracture who were admitted to a geriatric rehabilitation facility during 2014–2019. The Functional Independence Me...

ea0081p384 | Endocrine-Related Cancer | ECE2022

Appendiceal neuroendocrine neoplasms diagnosed during pregnancy-case series and review of the literature

Twito Orit , Amit Akirov , Chava Rosenblum Rachel , Herzberg Dana , Oleinikov Kira , Pnina Rotman-Pikielny , Glasberg Simona

Introduction: Although appendicitis occurs in approximately 1:1000 pregnancies, appendiceal neuroendocrine neoplasm (ANEN) diagnosis during pregnancy is very rare. Data on presentation, treatment and prognosis is scarce.Aim: To describe ANEN cases diagnosed during pregnancy.Materials and Methods: A retrospective appraisal of 7 consecutive ANEN patients diagnosed during pregnancy from four Israeli tertiary medical centers and compar...

ea0063p50 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

A seminoma with entrapped nerve ganglion masquerading as a paraganglioma

Rosenblum Rachel Chava , Atlan Karine , Diment Judith , Mazeh Haggi , Rotman-Pikielny Pnina , Twito Orit

Background: The differential diagnosis of retroperitoneal tumors includes lymphoid, germ cell and neurogenic tumors such as paraganglioma. Paragangliomas are rare neuroendocrine tumors of the autonomic nervous system, which may secrete catecholamines and their metabolites. Clinical features include sustained or paroxysmal hypertension, headaches, sweating and palpitations. Here we present an unusual case of a retroperitoneal tumor entrapping a sympathetic nerve ganglion and mi...

ea0063p107 | Calcium and Bone 1 | ECE2019

Pseudohypoparathyroidism- a tale of hypo- and hypercalcemia with a genetic solution

Chava Rosenblum Rachel , Einbinder Yael , Twito Orit , Mantovani Giovanna , Marta Elli Francesca , Rotman-Pikielny Pnina

Introduction: Pseudohypoparathyroidism (PHP) is a rare genetic disease characterized by renal resistance to parathyroid hormone (PTH), presenting with hypocalcemia, hyperphosphatemia and elevated PTH levels. We describe a PHP patient who presented with clinically significant hypercalcemia.Case description: A 46-year-old woman with a prior history of hypocalcemia presented to the emergency department with new-onset hypercalcemia, renal failure and anemia....

ea0049ep1391 | Thyroid (non-cancer) | ECE2017

The impact of age and gender on the presentation and prognosis of medullary thyroid cancer – an Israeli multicenter study

Twito Orit , Grozinsky-Glasberg Simona , Benbassat Carlos , Llevy Sigal , Bachar Gideon , Gross David J , Hirsch Dania

Background: Data regarding the effect of gender and age on medullary thyroid cancer (MTC) presentation and prognosis is limited. Although older age and male sex were found to correlate with poorer prognosis in some studies, this correlation may reflect differences in MTC presentation between sex and age groups, or a mixture of hereditary and sporadic MTC forms.Objective: To evaluate the impact of age and sex on the presentation and outcomes of MTC.<p...

ea0070aep623 | Pituitary and Neuroendocrinology | ECE2020

Temporal trends in incidence, evaluation and management of neuroendocrine neoplasms of the appendix-15 years’ experience

Twito Orit , Haim Paran , Shmuel Avital , Vladimir Kravtsov , Pnina Rotman-Pikielny , Noa Klein

Introduction: Appendiceal neuroendocrine neoplasms (ANEN) account for approximately 50% of all primary tumors of the appendix and are between the first and third-most frequent gastrointestinal neuroendocrine neoplasms. Data regarding trends in incidence, management and prognosis of ANEN is limited.Aims: To evaluate temporal trends in ANEN incidence, evaluation and management over a 13-year period.Materials and methods: Appendectomy...

ea0070ep71 | Bone and Calcium | ECE2020

Efficacy and safety of pamidronate in the treatment of parathyroid hormone-dependent hypercalcemia in hospitalized patients

Chava Rosenblum Rachel , Twito Orit , Barzilay-Yoseph Liat , Ramaty Erez , Klein Noa , Rotman-Pikielny Pnina

Background: Bisphosphonates are effective in malignancy-related hypercalcemia and have been beneficial in parathyroid-hormone (PTH)-dependent hypercalcemia in small randomized-controlled trials. However, data regarding efficacy and safety in PTH-dependent hypercalcemia is limited, and pamidronate is not indicated for this condition.Objective: To evaluate efficacy and safety of pamidronate in moderate-severe PTH-dependent hypercalcemia. Control groups wer...

ea0073aep135 | Calcium and Bone | ECE2021

Osteoporosis treatment following osteoporotic fractures- data from a single medical center

Tell-Lebanon Osnat , Rosenblum Rachel Hava , Yaccobi Eyal , Ohana Nissim , Twito Orit , Rotman-Pikielny Pnina

BackgroundMost post-osteoporotic fracture patients do not receive osteoporosis treatment, although it reduces risks for additional fractures. This retrospective, observational study reviewed osteoporosis evaluation and treatment following typical osteoporotic fractures.MethodsWe identified patients with hip, vertebral, humerus or radius fractures, examined in Meir Medical Center, January-December 2017. Exclus...

ea0073aep185 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Anemia in diabetes and pre-diabetes with normal kidney function: Prevalence and long- term association with morbidity and mortality

Erez Daniel , Shaefler Coral , Roitman Eytan , Levy Sigal , Ellis Martin , Dovrish Zamir , Twito Orit

BackgroundAlthough anemia was previously described as a complication of diabetes mellitus (DM), it’s prevalence and prognostic meaning in patients with DM and pre-DM with normal kidney function was not thoroughly investigated.MethodsA retrospective analysis of patients with DM and pre-DM referred to the endocrine institute in Meir medical center during 2015. Patients with estimated glomerular filtration ...