Searchable abstracts of presentations at key conferences in endocrinology

ea0035p26 | Adrenal cortex | ECE2014

Recovery of the hypothalamo–pituitary adrenal axis following successful surgical treatment in various forms of Cushing's syndrome

Palimeri Sotiria , Tzanela Marinella , Assimakopoulou Athina , Tsagarakis Stlylianos

It is well known that successful treatment of Cushing’s syndrome (CS) leads to transient adrenal insufficiency due to suppression of the hypothalamo–pituitary–adrenal (HPA) axis by the long-standing cortisol excess. Reports on HPA recovery in recent years including CS patients with less florid clinical features are scarce. Herein we report our findings in a series of patients with various forms of CS successfully treated in our department over the last 15 years....

ea0014p547 | (1) | ECE2007

Effect of treatment with somatostatin analogue on glucose homeostasis in patients with acromegaly

Gavalas Nikos , Sabo Andrea , Papastathopoulou Lida , Botoula Efi , Tzanela Marinella

Long acting somatostatin analogues (SMS) are extensively used as second and even first line treatment of acromegaly. Except of the inhibition of GH secretion, somatostatin is a potent inhibitor of insulin secretion from the pancreatic b- cells. As defects of glucose homeostasis are very common in acromegaly, we decided to examine the effect of the control of GH hypersecretion with SMS on glucose metabolism.We study 44 acromegalic patients divided in 3 gr...

ea0049ep1047 | Pituitary - Clinical | ECE2017

Considerable delays to achieve adequate control in treating patients with acromegaly

Tzanela Marinella , Karapanou Olga , Giatra Christianna , Botoula Efstathia , Tiaka Elisabeth , Anastasia Lambraki , Tsagarakis Stylianos

Acromegaly is a rare disease that leads to considerable morbidity and mortality, both reversible by adequate control of the disease. However, patients that could be adequately controlled confront delays in achieving treatment targets. The aim of the present study was to estimate the time to disease control after diagnosis and the reason leading to control delays. We retrospectively studied 119 acromegalic patients (aged 46.4±12.5; 71 females). Following appropriate treatm...

ea0032p896 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Effect of treatment outcome on co-morbidities of Cushing's disease

Assimakopoulou Athina , Tzanela Marinella , Palimeri Sotiria , Karapanou Olga , Botoula Efi , Tsagarakis Stylianos

Generously supported by IPSEN)-->Endogenous hypercortisolism leads to increased morbidity and mortality. As Cushing’s disease (CD) is a rare disorder, data on co-morbidities outcome after current treatment interventions are scarce.We studied 78 patients with CD (67 females, 11 males, mean age 42.2±1.4 years), with a follow up of 90.8±7.8 months. All patients underwent transsphenoidal surgery (TSS...

ea0022p701 | Obesity | ECE2010

The circulating pattern of adiponectin and resistin in critically ill patients with sepsis

Vassiliadi Dimitra , Tzanela Marinella , Dimopoulou Ioanna , Orfanos Stylianos , Kotanidou Anastasia , Armaganidis Apostolos , Tsagarakis Stylianos

Several alterations of the metabolic processes develop during sepsis. Adiponectin and resistin are amongst the main adipokines that may contribute to the metabolic adaptations observed in the context of critical illness. However, there is scarce data on the circulating pattern of these adipokines in human sepsis. Therefore we aimed to describe the variation in circulating levels of resistin and adiponectin during the course of sepsis and examine whether they are related to the...

ea0094p306 | Adrenal and Cardiovascular | SFEBES2023

The heterogeneous spectrum of adrenal ganglioneuromas: two interesting cases

Ntali Georgia , Kardalas Efstratios , Markou Maria , Mouchtouris Panagiotis , Partsalaki Eirini , Lavrentaki Aikaterini , Kyriakopoulos Georgios , Tzanela Marinella

Introduction: Ganglioneuromas (GNs) are rare, benign tumors, arising from neural crest cells. Their incidence amongst adrenal masses is 0.3%-6%. The majority are incidentalomas and hormonally inactive but a subset may cause compressive effects. Presentation in the context of genetic syndromes (NF1/NF2, RET, MAX, Von Hippel Lindau disease) has been reported. We present two cases of adrenal GNs: Case 1. A 31-year-old female patient who presented with a history o...

ea0063p1026 | Interdisciplinary Endocrinology 2 | ECE2019

Glucocorticoid receptor alpha and betaexpression, serum cortisol and cytokine levels in critical illness

Vassiliadi Dimitra Argyro , Vassiliou Alice , Stamogiannos G , Floros G , Botoula Efthymia , Jahaj Edison , Tzanela Marinella , Orfanos Stylianos E. , Kotanidou Anastasia , Dimopoulou Ioanna , Tsagarakis Stylianos

Purpose: HPA axis activation resulting in increased cortisol production by the adrenals is a crucial part of the response to critical illness. The action of cortisol may also be modulated at the tissue level, through changes in the availability of the free fraction and modifications of the glucocorticoid receptor activity. It has been proposed that tissue resistance to glucocorticoids may occur, at least in some patients, and relate to insufficient anti-inflammatory activity a...

ea0032p26 | Adrenal cortex | ECE2013

Longitudinal assessment of adrenocortical responses to low-dose ACTH in critically ill septic patients

Vassiliadi Dimitra A , Dimopoulou Ioanna , Zervou Maria , Tzanela Marinella , Tsagaris Hercules , Augustatou Callirrhoe , Douka Evangelia , Livaditi Olga , Orfanos Stylianos , Kotanidou Anastasia , Armaganidis Apostolos , Tsagarakis Stylianos

Introduction: The hypothalamo-pituitary adrenal axis has been extensively investigated in sepsis. Most studies concentrated in the acute phase and in most the high-dose ACTH stimulation test has been applied. Studies extending in the post-acute phase by using the more physiological low-dose ACTH stimulation are scarce.We aimed to investigate the time course of cortisol levels before and after stimulation with 1μg Synacthen in mechanically ventilated...