Endocrine Abstracts

Smoking is a modifyable risk factor in the incidence of impaired glucose tolerance and type 2 diabetes, but the data concerning the effect of smoking on the course of type 2 diabetes is limited. In this study, we aimed to investigate a possible relationship between smoking and the need of insulin therapy in patients with type 2 diabetes. 470 patients with type 2 diabetes were assessed for smoking habitus, marital and educational status, duration of diabetes, duration of insuli...

Acromegaly is known to be associated with insulin resistance. Visceral adipose tissue is increased in patients with insulin resistance and we aimed to investigate a visceral adipose tissue content as a possible marker of insulin resistance in diabetic and nondiabetic acromegalic patients. We compared 16 diabetic and 16 nondiabetic acromegalic patients for fasting blood glucose (FBG), insulin and visceral adipose tissue content calculated from abdominal computer tomography. All...

Acromegaly is known to be associated with both increased cardiovascular mortality and carbohydrate intolerance. The aim of our study is to compare intima-media thickness, a marker of atherosclerosis in active acromegalic patients with and without diabetes. 32 active acromegalic patients (M/ F: 15/17, 16 diabetic and 16 nondiabetic) were assessed for fasting blood glucose (FBG), insulin, growth hormone, insulin-like growth factor 1 and carotid intima-media thickness (IMT). Diab...

Increased heel pad thickness can be used as a marker of soft tissue enlargement in acromegalic patients. We aimed to investigate if concomittant hyperinsulinemia/and or diabetes secondary to insulin resistance in acromegaly contribute to the enlargement of heel pad. We compared heel pad thickness in 16 diabetic and 16 nondiabetic active acromegalic patients using X-ray images. All of the diabetics were well controlled with diet and/ or oral antidiabetic drugs. GH and IGF-1 wer...

Hungry bone syndrome (HBS) is associated with recent parathyroid surgery. The Wolfram syndrome is characterised by diabetes insipidus, diabetes mellitus, optic atrophy and deafness. Other anomalies, such as renal outflow tracts and multiple neurological disorders may develop later. We present a Wolfram patient with tertiary hyperparathyroidism due to chronic renal failure associated with bilateral reterohidronephrosis who developed prolonged HBS after parathyroid adenomectomy....

Objective: Polycystic ovary syndrome (PCOS) is closely associated with insulin resistance (IR) and about 50–70% of women with PCOS have significantly increased IR. Our study was performed to determine the effects of metformin on IR indices with lean PCOS patients.Methods: Our study was a single center, randomized prospective study, approved by the local ethical committee. 53 patients with BMI <25 kg/m2 who had chronic anovulation and ...

Objective: Hirsutism, is characterized by excessive growth of terminal hair in a male pattern. Idiopathic hirsutism (IH) is a common cause of hirsutism. Since there are few data demonstrating IH is associated with insulin resistance we tried to assess various insulin sensitivity indices in lean IH and compare with healthy subjects.Methods: A cross-sectional study was performed in 71 lean (BMI between 20–25 kg/m2) women (17–39 years o...

Objective: To evaluate the level of awareness among patients with thyroid disorders presenting to our hospital and determine patient profiles.Design: The present study was conducted using a survey technique on patients aged between 18 and 75 years, who were admitted to our hospital for follow-up between December 1, 2014 and December 31, 2014. The pregnant women and those with a thyroid malignancy and patients who did not consent for the study were exclud...

Objective: The present study aimed to evaluate thyroid stimulating hormone (TSH) levels and anti-thyroid peroxidase antibodies (anti-TPOab) in euthyroid subjects with metabolic syndrome (MetS) and to compare them with healthy subjects without MetS.Design: Study included 173 subjects consisted of 96 subjects with MetS and 77 healthy controls. Gender, age, body mass index (BMI), waist circumfrence (WC), and detailed medical history of all participants were...