Endocrine Abstracts

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

Objective: Diabetes mellitus (DM) is a complex disease that affects many systems. The most important cells of the immune system are lymphomononuclear (LMN) cells. Here, we aimed to evaluate the energy metabolism of LMN cells in patients with diabetes and impaired glucose tolerance.Methods: We measured LMN cell energy metabolism in patients with type 2 diabetes mellitus, impaired glucose tolerance (IGT) and healthy subjects. Cells were freshly isolated fr...

Obesity is a risk factor for calcaneal spur (CS) formation which is supposed to originate from chronic plantar fasciitis. But histological findings support the thesis that ‘plantar fasciitis’ is a degenerative fasciosis without inflammation. Diabetes mellitus may contribute to the risk of CS by decreased ability of tissue repair and increased reactive ossification. Thus, we aimed to determine CS incidence in asymptomatic obese subjects with and without type 2 diabete...

While low testosterone levels are associated with higher incidence of type 2 diabetes mellitus in males. In contrast, hyperandrogenism is associated with higher risk of type 2 diabetes mellitus in females.We, therefore, have assessed alterations in beta-cell functions before and after testosterone replacement therapy in male patients with idiopathic hypogonadotropic hypogonadism (IHH) and before and after anti-androgen therapy in patients with polycystic...

Hypogonadism is associated with increased body fat content and insulin resistance. Many associations including ADA, IDF and EASD declare that waist circumference is a reliable measure of visceral adiposity and may account for insulin resistance. Our observations in young male patients with idiopathic hypogonadotrophic hypogonadism (IHH) are opposite. Thus, we aimed to compare body fat content and anthropometric measurements between patients and age-matched eugonadal healthy co...

Introduction: Hemoglobin (Hb) is the main carrier and buffer of Nitric oxide. Recently, an inverse association between Hb and the endothelium dependent relaxation was observed in patients with Type 2 diabetes. Testing whether this association exists also in diabetic nephropathy is important because anemia in these patients starts at an earlier stage than in other renal disease. Also, at population level diabetes and renal dysfunction, particularly albuminuria, contribute indep...

Visfatin is a newly discovered adipocyte hormone. Recent studies showed a possible relationship between diabetes mellitus and visfatin level. But the effect of visfatin on the insulin resistance was not well understood. The aim of the present study was to explore the relation of visfatin with insulin resistance in patients with prediabetes and diabetes.We included a total of 128 persons in the study and of these 128 persons, 36 were diabetic, 69 were pre...

Metabolic disorders and cardiovascular events are increased in hypogonadism. Serum HDL composition is a better cardiovascular predictor than the HDL counts. However, there is no information about the HDL subfractions in patients with hypogonadism. We designed a prospective study to investigate the HDL subfractions in treatment naïve subjects with hypogonadism and the effects of two different testosterone replacement regimens on the HDL subfractions. Seventy young male pat...

The relation between obesity and diabetes mellitus is known for long periods and this relation is based on insulin resistance. Recent studies showed that epicardial adipose tissue thickness measured by echocardiography is the marker of the visceral adipose tissue and cardiovascular risk. Visfatin is a new described adipokine and it has been showed to have mRNA expression in epicardial adipose tissue. There is a conflict about the role of visfatin on obesity, insulin resistance...