Searchable abstracts of presentations at key conferences in endocrinology

ea0090p489 | Thyroid | ECE2023

Microscopic Calcifications Isolated from Thyroid Nodule Fine Needle Aspiration Can Serve as Biomarkers of Thyroid Nodule Malignancy

Yoel Uri , Fraenkel Merav , Gotnayer Lotem , Aranovich Dina , Vidavsky Netta

Background: When US characteristics and the diameter of a thyroid nodule (TN) justify further evaluation to rule out or to establish the diagnosis of thyroid cancer (TC), fine needle aspiration (FNA) biopsy for cytology (FNAC) is indicated. A major limitation of FNAC is the high rate of indeterminate significance (~30%) results, which require further evaluation. Although recently introduced molecular testing contributed to the ability to differentiate benign from malignant TNs...

ea0063p945 | Diabetes, Obesity and Metabolism 3 | ECE2019

The association between glycemic control and hip fracture risk – a retrospective Cohort study

Yoel Uri , Zimhony-Nissim Noa , Novack Victor , Fraenkel Merav

Introduction: Fragility fractures are increasingly recognized as a complication of diabetes mellitus (DM). Disease duration, poor glycemiccontrol, diabetes complication, and glycemic variability may be associated with increased risk.Aim: To investigate the association between glycemic control and hip fracture (HF) risk in a cohort of diabetic patients.Methods: This retrospective cohort study included all patients 50 years and older...

ea0081ep984 | Thyroid | ECE2022

Thyroglobulin is a poor predictor of differentiated thyroid cancer in patients operated for thyroid nodular diseases

Rigbi Shoham , Baraf Lior , Joshua Ben-Zion , Yoel Uri , Fraenkel Merav

Background: Thyroglobulin, serves as a specific tumor marker following thyroidectomy in differentiated thyroid cancer (DTC) patients. However, its role as DTC predictor in patients with thyroid nodules (TN) is controversial.Aim: We aimed to assess the potential role of preoperative serum thyroglobulin concentration to predict DTC in patients who were operated for thyroid nodular disease.Methods: This retrospective study included pa...

ea0090p129 | Pituitary and Neuroendocrinology | ECE2023

Asymptomatic Familial Hyperprolactinemia Caused by a Unique bi-Allelic Variant in the Prolactin-Receptor Gene

Natif Yoav , Jean Matan M. , Birk Ohad S. , Eskin-Schwartz Marina , Fraenkel Merav , Yoel Uri

Introduction: Hyperprolactinemia is usually an acquired condition. Typical clinical manifestations include hypogonadism, infertility, and galactorrhea. Rarely, hyperprolactinemia has been attributed to a variant in the prolactin receptor gene (PRLR), presenting as agalactia, without hypogonadism, infertility, or galactorrhea.Aim: In the current study we aimed to delineate the clinical phenotype and the genetic basis of marked hyperprolactinemia ...

ea0090p751 | Thyroid | ECE2023

Thyroglobulin Point of Care Assay for Rapid Detection of Metastatic Differentiated Thyroid Carcinoma- A Pilot Study

Yoel Uri , Angel Sagi , Bosin Emily , Elezra Miri , Marks Robert S. , Fraenkel Merav

Introduction: Fine needle aspiration (FNA) for thyroglobulin (Tg) measurement (FNA-Tg) and for cytology (FNAC) are recommended for the evaluation of cervical lymph nodes (LN) suspected as differentiated thyroid carcinoma (DTC) metastases. LN proven to represent a metastasis of thyroid origin, change the operation plan, both prior to surgery and while encountering suspicious LN during surgery.Aim: To assess the diagnostic accuracy of a novel point-of-care...

ea0090p310 | Calcium and Bone | ECE2023

The impact of a post hip fracture FLS on mortality and recurrent fracture - a tertiary medical center retrospective study

Alkobi-Weiss Hadar , Goldbart Adi , Hassan Lior , Polischuk Vera , Press Yan , Siris Ethel , Yoel Uri , Fraenkel Merav

Background: Rates of osteoporosis treatment following hip fractures are low. Fracture liaison service (FLS) has been shown to increase medical treatment for osteoporosis and decrease mortality. The aim of our study was to assess the impact of in hospital FLS on mortality and second hip fracture.Methods: This retrospective study included patients over 65 years of age, insured by “Clalit” health service who were admitted to Soroka University Medi...

ea0037gp.20.03 | Pituitary – Hypopituitarism | ECE2015

Timing is everything? Postpartum pituitary dysfunction – variability of clinical and radiological presentation

Tirosh Amit , Iraqi Hiba Masri , Hirsch Dania , Robenshtok Eyal , Yoel Uri , Toledano Yoel , Twito Orit , Tsvetov Gloria , Shimon Ilan

Introduction: Two aetiologies are responsible for postpartum hypopituitarism; Sheehan’s syndrome which develops following traumatic labour, and lymphocytic hypophysitis. Since management of lymphocytic hypophysitis does not require surgery in most cases, pathology is usually absent, and the clinical presentation, in combination with laboratory and imaging characteristics establish the diagnosis. We aimed to describe the various patterns of presentation, including assistin...

ea0081oc6.4 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Clinical correlates of a large Israeli cohort of Cys 618 Arg RET mutation

Chava Rosenblum Rachel , Hirsch Dania , Glasberg Simona , Benbassat Carlos , Yoel Uri , Ishay Avraham , Lamprecht Sagit Zolotov , Bachar Gideon , Banne Ehud , Twito Orit

Introduction: A syndrome of MEN2A and Hirschsprung’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...