Endocrine Abstracts

Background: When US characteristics and the diameter of a thyroid nodule (TN) justify further evaluation to rule out or to establish the diagnosis of thyroid cancer (TC), fine needle aspiration (FNA) biopsy for cytology (FNAC) is indicated. A major limitation of FNAC is the high rate of indeterminate significance (~30%) results, which require further evaluation. Although recently introduced molecular testing contributed to the ability to differentiate benign from malignant TNs...

Introduction: Fragility fractures are increasingly recognized as a complication of diabetes mellitus (DM). Disease duration, poor glycemiccontrol, diabetes complication, and glycemic variability may be associated with increased risk.Aim: To investigate the association between glycemic control and hip fracture (HF) risk in a cohort of diabetic patients.Methods: This retrospective cohort study included all patients 50 years and older...

Background: Thyroglobulin, serves as a specific tumor marker following thyroidectomy in differentiated thyroid cancer (DTC) patients. However, its role as DTC predictor in patients with thyroid nodules (TN) is controversial.Aim: We aimed to assess the potential role of preoperative serum thyroglobulin concentration to predict DTC in patients who were operated for thyroid nodular disease.Methods: This retrospective study included pa...

Introduction: Hyperprolactinemia is usually an acquired condition. Typical clinical manifestations include hypogonadism, infertility, and galactorrhea. Rarely, hyperprolactinemia has been attributed to a variant in the prolactin receptor gene (PRLR), presenting as agalactia, without hypogonadism, infertility, or galactorrhea.Aim: In the current study we aimed to delineate the clinical phenotype and the genetic basis of marked hyperprolactinemia ...

Introduction: Fine needle aspiration (FNA) for thyroglobulin (Tg) measurement (FNA-Tg) and for cytology (FNAC) are recommended for the evaluation of cervical lymph nodes (LN) suspected as differentiated thyroid carcinoma (DTC) metastases. LN proven to represent a metastasis of thyroid origin, change the operation plan, both prior to surgery and while encountering suspicious LN during surgery.Aim: To assess the diagnostic accuracy of a novel point-of-care...

Background: Rates of osteoporosis treatment following hip fractures are low. Fracture liaison service (FLS) has been shown to increase medical treatment for osteoporosis and decrease mortality. The aim of our study was to assess the impact of in hospital FLS on mortality and second hip fracture.Methods: This retrospective study included patients over 65 years of age, insured by “Clalit” health service who were admitted to Soroka University Medi...

Introduction: Two aetiologies are responsible for postpartum hypopituitarism; Sheehan’s syndrome which develops following traumatic labour, and lymphocytic hypophysitis. Since management of lymphocytic hypophysitis does not require surgery in most cases, pathology is usually absent, and the clinical presentation, in combination with laboratory and imaging characteristics establish the diagnosis. We aimed to describe the various patterns of presentation, including assistin...

Introduction: A syndrome of MEN2A and Hirschsprung’s disease described in Israeli Jews of Moroccan descent is caused by Cys 618 Arg mutation, one of the less common causes of MEN2A. We aimed to define the clinical characteristics of a large cohort with this mutation from a multi-center Israeli registry.Methods: The Israeli MTC registry including 8 centers was searched retrospectively for results of RET mutational analysis. Patients with a Cys 618 Ar...