Endocrine Abstracts

Introduction: Teriparatide (TPTD) is a recombinant aminoterminal fragment (1–34) of the human parathyroid hormone (PTH), which has a predominantly stimulating effect on bone formation. We report results of an 18-month prospective multicenter study with daily s.c. application of 20 μg of teriparatide in 85 elderly women with severe osteoporosis, the efficacy, safety and compliance of the treatment.Outcomes: The primary outcomes were defined as c...

Background: Endogenous Cushing’s syndrome (CS) comprises the symptoms and signs associated with prolonged exposition to inappropriately high levels of glucocorticoids produced by adrenal cortex. Epidemiological studies reported an incidence of 0.7–2.4 cases per 1 million inhabitants per year. Late-night salivary cortisol (LNSC) is one of three currently recommended initial screening tests for CS. The advantages of LNSC are nonivasive specimen collection and minimal i...

Background: Although the excision of ACTH-producing tumors or adrenal tumors is the principal treatment for Cushing syndrome (CS), pharmacologic treatment has a well-established role. Among various medical agents, ketoconazole (KTZ) has inhibitory effect over 17,20 desmolase, 17α-hydroxylase, 11β-hydroxylase, and 16α- and 18-hydroxylase; moreover, it also inhibits ACTH production and cellular growth, partly because of apoptosis induction.C...

Background: The presence of functional ACTH receptors (MC2R) on osteoblasts and fact, that their activation lead to the proliferation of osteoblasts is consistent with the presence of receptors for another anterior pituitary hormones (FSH and TSH) on bone cells. Does ACTH directly regulate bone? Is it possible, that this is another hormone of a novel regulatory axis, pituitary-bone axis, in which hormones bypass traditional endocrine targets to regulate bone mass directly? Sup...

Authors present a 35-year-old female with thyroid orbitopathy (EO) associated with Graves disease. After initial antithyroid therapy, thyroidectomy was indicated and performed uneventenfully. Due to persisting severe clinically active EO, thyroablative therapy with 131I was performed three years later, intravenous pulse of methylprednisolone was given and consecutive oral therapy with prednisone initiated. This caused weight gain (from 63 to 80 kg) and iatrogenic Cu...

Backrgound: Coexistent gastrointestinal pathology might alter hydrocortisone (HCT) and levothyroxine (LT4) absorption and gut transit times.Aims: To screen patients with autoimmune Addison disease for the presence of serological markers of autoimmune gastrointestinal disorders, to compare doses of HCT and LT4 in patients with positive autoantibodies to those of patients without signs of autoimmune gastroenteropathy.Subjects and met...

Background: Newborn screening is the only systematic work-up of thyroid disorders in Slovakia with unambigously proven positivities. There is wide discussion regarding the screening of thyreopathies in specific risk groups such as pregnant women.Aims: To study the gynaecologist and endocrinologist co-operation in screening pregnant patients from region of Liptov and Orava for autoimmune thyroiditis.Subjects and methods: The partici...

Introduction: A form of ACTH-dependent Cushing syndrome is an ectopic production of ACTH. The aetiology can by benign lesion or a malignant non-pituitary tumor, which is more common. The prevalence of endogenous Cushing syndrome is 1 in 26 000. Ectopic ACTH secretion is responsible for 7–15% of the cases. Principal position of the ACTH-producing tumor is in lungs – a bronchial endocrine tumor and small cell lung cancer. Small peripheral bronchial carcinoids can easil...

Carney complex (CNC) is rare autosomal dominant disorder, which was firstly described as a combination of manifestation of myxomas, spotty skin pigmentation and endocrine overactivity in 1985. This condition affects many organs and varies in clinical manifestation. The presence of at least two clinical signs is considered as pathognomonic with regard to a sporadic form of CNC, and an evidence of at least one sign with simultaneous manifestation of CNC in any of first degree re...

Introduction: GH deficiency (GHD) is associated with reduced bone mineral density (BMD) and treatment leads to its increase. BMD, a quantitative bone parameter, doesn’t bring whole information about bone status. Nowadays, bone quality shows as main determinant of bone strength, fracture prediction and treatment effect monitoring. A method to assess bone quality through the grey-level texture analysis from lumbar spine DXA scan is trabecular bone score (TBS).<p class="...