Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep126 | Clinical case reports - Pituitary/Adrenal | ECE2017

Clinical case of aldosterone-producing adrenocortical carcinoma

Krivosheev Alexey , Voronkova Iya , Platonova A , Britvin Timur

Aldosterone-secreting adrenocortical carcinoma (ACC) is rare neoplasm, which detected in 2.5% of active ACCs.Clinical case: A 58 years old female, was admitted to our clinic with complaints of high blood pressure, back pain, weakness, convulsions. Biochemical evaluation confirmed primary hyperaldosteronism (serum aldosterone 1012 pg\ml, serum renin concentration 0.5 mkME\ml, aldosterone-renin ratio 202.4, hypokalemia 1.2 mmol\l). There was no evidence of...

ea0049ep318 | Clinical case reports - Thyroid/Others | ECE2017

Clinical case of atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures

Eremkina Anna , Mokrysheva Natalia , Krupinova Julia , Mirnaya Svetlana , Voronkova Iya

Introduction: Atypical parathyroid adenoma (APA) is rarely encountered cause of primary hyperparathyroidism (PHPT). No definite criteria are considered to distinguish preoperatively APA from parathyroid typical adenoma or carcinoma.The aimTo describe the clinical course of a patient with an atypical parathyroid adenoma with severe hypercalcemia and multiple fragility fractures.Case presentation: A 61-year-old...

ea0032p713 | Neuroendocrinology | ECE2013

Clinical case of silent corticotropinoma

Dzeranova Larisa , Lipatenkova Anna , Pigarova Ekaterina , Voronkova Iya

Silent corticotropinomas (SCAs) are a subtype of non-functioning pituitary adenomas (NFPAs) demonstrating positive immunoreactivity for ACTH, but without clinical or biochemical features of hypercortisolism. SCAs typically present as macroadenomas with symptoms related to a local mass effect. In some cases SCAs can transform into hormonal active formations with gradually developing symptoms of hypercortisolism.The aim: To describe a patient with NFPA who...

ea0056p917 | Female Reproduction | ECE2018

The paracrine endometrium expression in women with autoimmune thyroid imbalance and spontaneous abortion

Fris Ksenia , Andreeva Elena , Platonova Nadezhda , Voronkova Iya

Context: Autoimmune thyroid pathology can lead to serious complications of pregnancy and can be combined with generalized autoimmune imbalance, in particular, in the endometrium. The imbalance in the regulation of the immunocompetent cells activity and the increase of cytokines production are one of the reasons for the failed implantation or disruption of embryo development with future consequencesObjective: To assess the role of paracrine factors (expre...

ea0056p919 | Female Reproduction | ECE2018

Endometrium steroid receptors expression in women with autoimmune thyroid pathology and reproductive failures

Fris Ksenia , Andreeva Elena , Platonova Nadezhda , Voronkova Iya

The complex study of the endometrium, in particular, immunohistochemical (IHC), allows to determine the state of steroid receptivity and allows to choose the optimal way of examination in women with autoimmune thyroid diseases and miscarriages.Aim: To evaluate IHC expression of steroid receptors (ERα, ERβ, PR) in endometrium in women with a history of reproductive loss and autoimmune thyroid diseasesMaterials and methods:...

ea0073yi12 | Young Investigator Awards | ECE2021

Preoperative predictors and prognostic factors of recurrence of the parathyroid carcinoma – Data of a multi-center study

Krupinova Julia , Voronkova Iya , Aynetdinova Alina , Pigarova Ekaterina , Mokrysheva Natalia

BackgroundThere are no specific markers for parathyroid carcinoma (PC) therefore, the development of algorithms for identifying high-risk patients is an urgent task.AimsTo determine clinical and laboratory predictors of PC and identify the factors of a poor prognosis.Materials and methodsA multi-center retrospective study included 242 patients with primary hyperpa...

ea0073aep380 | Endocrine-Related Cancer | ECE2021

Multiple metastases of parathyroid carcinoma and papillary thyroid carcinoma in a female patient treated with long-term hemodialysis

Krupinova Julia , Eremkina Anna , Dobreva Ekaterina , Voronkova Iya , Mokrysheva Natalia

The combination of thyroid and parathyroid carcinoma (PC) are extremely rare. We present a case with metastases of both tumors to the lymph nodes of the neck in a woman who received renal replacement therapy with long-term hemodialysis.Case reportIn 1984, when she was 24 years old, the patient began working at a nuclear power plant as a chemical water treatment operator. The total length of service was 25 years. In 2009 (at the age...

ea0063gp227 | Adrenal and Neuroendocrine - Clinical (1) | ECE2019

Multikinase inhibitors for the treatment of progressive, metastatic parathyroid cancer

Krupinova Julia , Mokrysheva Natalia , Pigarova Ekaterina , Gorbunova Vera , Voronkova Iya , Rozhinskaya Liudmila

Introduction: The treatment of choice for parathyroid carcinoma (PC) is a radical en bloc resection. Treatment options for patients with metastatic PC are limited especially if a complete tumor removal cannot be performed. We present four cases of PC patients with multiple metastasis and refractory hypercalcemia that eventually received a multikinase inhibitor with different response on therapy.Clinical cases: The first patient was a 27-year-old woman wi...

ea0049ep323 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid carcinoma can be misdiagnosis with medullary thyroid cancer: how is that possible?

Mokrysheva Natalia , Krupinova Julia , Pigarova Ekaterina , Platonova Nadezhda , Voronkova Iya , lanschakov Kirill

Background: Hypercalcemia may stimulate thyroid’s C-cells to produce the calcitonin, that could lead to misdiagnosis of medullary thyroid cancer.Clinical case: A 47-year-old woman suffered from fracture of the left knee. She could not walk and used a wheelchair. CT scan in a public hospital detected multiple bone lytic changes in the ribs and vertebrae (mts?), tumor in the liver (mts?) and node in the thyroid gland 2.6*1.9 cm. Thyroid biopsy showed ...

ea0041ep13 | Adrenal cortex (to include Cushing's) | ECE2016

Immunohistochemical characteristics of blood vessels in non-visualized and visualized on MRI pituitary adenomas in patients with Cushing’s disease (pilot study)

Voronkova Iya , Belaya Zhanna , Khandaeva Patimat , Rozhinskaya Liudmila , Vorontsov Alexander , Sitkin Ivan , Grigoriev Andrey , Melnichenko Galina

Introduction: Regardless of improvements in MRI, up to 20% of ACTH-secreting pituitary tumors are only identified at surgical exploration. The objective was to estimate whether there is any difference in blood vessels and the subsequent ability to uptake contrast agent in visualized micro-adenomas as compared to non-visualized on MRI ACTH-secreting pituitary tumors.Materials and methods: Retrospective evaluation of ACTH-positive pituitary tumors from pat...