Searchable abstracts of presentations at key conferences in endocrinology

ea0022p546 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Plasma agouti-related peptide (AgRP) levels in male patients with hypogonadotropic hypogonadism

Demirci Hakan , Yonem Arif , Gozum Gunay , Ozata Metin

Objective: Agouti related peptide (AgRP), the endogenous antagonist of the melanocortin 3 and 4 receptors, is expressed at high levels in the arcuate nucleus of the hypothalamus. Some studies have demonstrated that intracerebroventricular AgRP administration increases plasma LH, FSH, testosterone levels. It also increases hypothalamic LHRH release in vitro, an effect that can be prevented by addition of melanocyte stimulating hormone. These findings suggest that AgRP ma...

ea0041ep307 | Clinical case reports - Pituitary/Adrenal | ECE2016

A rare complication of macroprolactinoma treatment with cabergoline: herniation of optic chiasma

Ahmet Ay Seyid , Baskoy Kamil , Ozalper Veysel , Deniz Ferhat , Yonem Arif

Introduction: Prolactinoma is the most common form of all pituitary tumors, and currently, treatment with cabergoline constitutes first choice therapy for prolactinoma. Surgical approach is recommended when medical therapy fails or visual disturbance due to pituitary mass develops. Here we present a case of macroprolactinoma who developed empty sella and optic chiasm protrusion secondary to cabergoline treatment.Case: A 20-year-old male patient referred ...

ea0041ep308 | Clinical case reports - Pituitary/Adrenal | ECE2016

A rare case of panhypopituitarism: pituitary stalk interruption syndrome

Baskoy Kamil , Ahmet Ay Seyid , Basbug Barbaros , Deniz Ferhat , Yonem Arif

Introduction: Hypopituitarism is characterized by decreasing of pituitary hormones, which can result from diseases of the pituitary gland or the hypothalamus. The prevalence of hypopituitarism is 30–45 out of 100 000 in the world wide. Causes of panhypopituitarism are non-tumoral hypotalomopituitary reasons (50%), pituitary tumors (43%) and extra-pituitary tumors (7%). Here we want to present a very rare case of pan hypopituitarism; pituitary stalk interruption syndrome (...

ea0041ep320 | Clinical case reports - Pituitary/Adrenal | ECE2016

A case of Cushing syndrome: long-time before being diagnosed ultimately in despite of abdominoplasty and reduction mammoplasty

Ahmet Ay Seyid , Baskoy Kamil , Ozalper Veysel , Deniz Ferhat , Yonem Arif

Introduction: Cushing’s disease (CD) is rare systemic disease characterized by an endogenous hypercortisolism and it is the most common cause of Cushing’s syndrome (CS). CS is encountered more often in women than in men, associated with an increased morbidity and mortality. Hence, early diagnosis and proper management of the condition is crucial. Here, we present a case of CD, who had abdominoplasty and reduction mammoplasty but went undiagnosed long time with correc...

ea0041ep386 | Clinical case reports - Thyroid/Others | ECE2016

A rare variant of hyperthyroidism: unilateral Graves’ disease

Deniz Ferhat , Baskoy Kamil , Ay Seyid Ahmet , Urhan Muammer , Yonem Arif

Introduction: Despite the fact that Graves’ disease (GD) almost always presents as a diffuse hyperfunctioning goiter involving both lobes of the thyroid gland, it may rarely reveal at only unilateral lobe with bilobar thyroid gland. We herein present a case of unilateral GD involving the right thyroid lobe of a bilobar gland.Case report: A 42-year-old woman presented with symptoms and signs of hyperthyroidism; thyrotropin (TSH) was undetectable, whi...

ea0070ep417 | Thyroid | ECE2020

Refractory hypothyroidism: What else should be done?

Ozum Nursah , Yay Adnan , Yaman Miray , Ozsari Levent , Deniz Ferhat , Yonem Arif

The treatment of hypothyroidism is straightforward,replacing with orally L-thyroxine(LT4).However,some factors including malabsorption,pancreas and liver disorders,drug interactions,etc.,may impair the absorption of LT4,and cause therapy failures.In these circumstances,high doses of different oral formulae or parenterally given LT4 may be a solution. Here,we present a case of primary hypothyroidism,resistant to high doses of oral LT4 replacement but,responsive parenteral LT4 a...

ea0041gp72 | Diabetes | ECE2016

Olfactory and gustatory functions in patients with non-complicated type 1 diabetes mellitus

Baskoy Kamil , Ay Seyid Ahmet , Hira Serdar , Salihoglu Murat , Deniz Ferhat , Yıldırım Aynur , Altundag Aytug , Yonem Arif , Tekeli Hakan , Hummel Thomas

Introduction: Olfactory and gustatory dysfunction in patient with diabetes mellitus (DM) and its pathophysiology were studied in many previous studies. Some studies reported that there was a relationship between type 1 DM (T1DM) and olfactory and gustatory functions the presence of diabetic complications. However findings are limited and controversial. The aim of this study was to determine the relationship between olfactory and gustatory scores and patients with non-complicat...

ea0041ep405 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

A novel E108D mutation of AVP-NPII gene in a Turkish patient with central diabetes insipidus

Ozcan Merve , Karaduman Tugce , Saglar Emel , Erdem Beril , Deniz Ferhat , Yonem Arif , Baskoy Kamil , Ahmet Ay Seyit , Oflaz Ofcan , Mergen Hatice

Familial central or neurohypophyseal diabetes insipidus (FNDI) results from insufficient production of antidiuretic hormone arginine vasopressin, which is caused by mutations in arginine vasopressin-neurophysin II gene (AVP-NPII). In this study, we present the clinical features of a male Turkish patient with autosomal dominant neurohypophyseal DI caused by a novel mutation (p.E108D). The prospective clinical data were collected for the proband patient and his family members. T...

ea0041ep420 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Molecular and clinical identification of A45T mutation in AQP2 gene

Karaduman Tugce , Ozcan Merve , Saglar Emel , Erdem Beril , Deniz Ferhat , Yonem Arif , Baskoy Kamil , Ay Seyit Ahmet , Oflaz Ofcan , Mergen Hatice

Diabetes insipidus (DI) is a disorder which is rarely seen and it is characterized by polydipsia and polyuria. Inadequate secretion of arginine vasopressin (AVP) from hypothalamus or inadequate response of kidney cells to AVP could be causes of DI. Therefore, any mutations in AVPR2, AVP and AQP2 genes which are the parts of that stimulation and response pathyway can cause DI. In this study, mutational analyse was performed for A45T mutation in AQP2 gene. We present a novel hom...