Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep837 | Clinical case reports - Pituitary/Adrenal | ECE2017

Multifocal multisystem langerhans cell histiocytosis – a rare cause of panhypopituitarism and diabetes insipidus – a case report

Gabalec Filip , Simkovic Martin , Kasparova Petra , Zak Pavel , Cap Jan

Introduction: Langerhans cell histiocytosis (LCH) is a very rare disease in adults and as well a very rare cause of sellar expansion. The clinical presentation can be heterogeneous, from a single bone lesion to potentially fatal, widespread disease. We describe the difficulties with the evaluation and the treatment of LCH.Case: 39 years old woman has had amenorrhea for 2 years and higher intake of fluids (5–7 l/day) for 6 years. Non-functioning pitu...

ea0070aep929 | Thyroid | ECE2020

No important salivary gland damage following radioiodine remnant ablation

Krcalova Eva , Horacek Jiri , Gabalec Filip , Zak Pavel , Dolezal Jiri

Radioiodine (131I, RAI) has traditionally been used in thyroid cancer treatment but its benefitshould be balanced against possible risks. Among them, salivary gland dysfunction has oftenbeen discussed, although the reported data have been inconsistent. While some authors reported functional changes following higher (mostly cumulative) activities, there have been scarce data on the activity of 3.7 GBq (100 mCi) that is most commonly used for RAI remnant ablation...

ea0041ep315 | Clinical case reports - Pituitary/Adrenal | ECE2016

Posture-responsive primary aldosteronism – the utility of seated saline suppression test

Jakubikova Iva , Horacek Jiri , Spitalnikova Sylvie , Ballon Marek , Lojik Miroslav , Gabalec Filip , Zak Pavel

Introduction: The diagnostic procedure of primary aldosteronism (PA) includes one of four confirmatory tests, of which the saline suppression test (SST) seems to be the most convenient one. Current guidelines recommend SST to be performed in a recumbent position. However, a recent preliminary study demonstrated a higher sensitivity of SST when performed in the upright (i.e. seated) position. Here, we report a case of posture-responsive PA with a negative recumbent SST but clea...

ea0056oc9.3 | Thyroid from basics to clinics | ECE2018

A mouse model of BRAF V600E mutated papillary thyroid cancer imitating sporadic conditions

Jakubikova Iva , Schoultz Elin , Johansson Ellen , Liang Shawn , Patyra Konrad , Kero Jukka , Zak Pavel , Nilsson Mikael

Introduction: Worldwide constantly rising incidence of thyroid cancer promotes research activities. Nowadays the most speculated issue is the clinical significance of BRAF mutation. For sure BRAF mutation is a cancer-specific somatic mutation consistent with papillary thyroid cancer phenotype, otherwise, its role in tumor aggressiveness, progression, and the overall poor outcome is controversial. As far as several clinical studies claim opposing opinions, the learning aspect o...

ea0032p1042 | Thyroid (non-cancer) | ECE2013

Haemodialysis-induced changes in thyroid hormones and thyrotropin

Horacek Jiri , Sulkova Sylvie Dusilova , Malirova Eva , Dlabalova Blanka , Safranek Roman , Kubisova Michaela , Kalousova Marta , Maly Jaroslav , Zak Pavel

Introduction: In end-stage renal disease (ESRD), thyroid function tests are often abnormal, and their interpretation is not always straightforward. While haemodialysis (HD) procedure has well-established profound effects on the serum levels of a variety of molecules no such data have been published on thyroid hormones.Methods: In 110 ESRD patients, total and free thyroxine (T4 and fT4), total and free triiodothyronine (T3...