Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep84 | Calcium and Bone | ECE2021

Non-nuclear cataracts in hypoparathyroidism are associated with biochemical control of the disease

Zavatta Guido , Tebben Peter , Clarke Bart L.

IntroductionA high calcium-phosphate product is thought to increase the risk of soft tissue calcification in hypoparathyroidism, including cataracts. Based on small case series, cataracts in hypoparathyroidism typically develop in the posterior subcapsular region of the lens. However, the mechanism of cataract formation is still not well understood.Materials and methodsIn a large cohort of 1014 patients with ...

ea0081p561 | Calcium and Bone | ECE2022

Nutritional and clinical manifestations of normocalcemic hyperparathyroidism in women: interim results from a case-control cross-sectional study evaluating dietary calcium intake with three validated questionnaires

Malagrino Matteo , Altieri Paola , Clarke Bart , Pagotto Uberto , Zavatta Guido

Context: Normocalcemic hyperparathyroidism (NHPT) is considered as an earlier or milder phenotype compared to traditional primary hyperparathyroidism (PHPT). To make a correct diagnosis, secondary hyperparathyroidism due to low calcium intake must be excluded. Whether calcium intake might affect presentation of PHPT vs NHPT has never been addressed consistently.Objective: To describe patients with a diagnosis of NHPT or PHPT in relation to their calcium ...

ea0081ep195 | Calcium and Bone | ECE2022

Management of denosumab discontinuation in a patient with osteonecrosis of the jaw and coexisting primary hyperparathyroidism

Malagrino Matteo , Belardinelli Elisabetta , Altieri Paola , Pagotto Uberto , Zavatta Guido

Context: Patients with primary hyperparathyroidism (PHPT) may be treated with denosumab due to coexisting osteoporosis. Few studies have been conducted in this population.Case presentation: An 84-year-old woman was seen in the outpatient clinic in March 2018 due to calcium levels at the upper limit of reference range (10,2 mg/dl) associated with elevated levels of PTH (112 pg/ml) and sufficient 25(OH)Vit D (24 ng/ml) levels, findings consistent with mild...

ea0073aep153 | Calcium and Bone | ECE2021

Unexpected association of severe hypercalcemia and hypophosphatemia in a patient with chronic hypoparathyroidism: A case report

Vandi Giulia , Zavatta Guido , Repaci Andrea , Altieri Paola , Pagotto Uberto

Clinical vignetteA 65-year-old woman was hospitalized due to severe hypercalcemia (albumin-corrected calcium 16.9 mg/dl) associated with severe renal failure (creatinine 3.48 mg/ml), normal phosphate levels (3.9 mg/dl) and PTH < 5 pg/ml. Her past medical history included total thyroidectomy complicated by chronic hypoparathyroidism, for which she was followed by her primary care physician. One year before hospital admission, renal function was normal...

ea0063p502 | Calcium and Bone 2 | ECE2019

Evaluation of bone metabolism in women on aromatase-inhibitors before and after antiresorptive treatment

Vandi Giulia , Zavatta Guido , Repaci Andrea , Di Dalmazi Guido , Altieri Paola , Pagotto Uberto

Introduction: Adjuvant therapy with aromatase-inhibitors (AIs) increases bone loss and fracture risk. Concomitant antiresorptive treatment is currently recommended. The aim of this study was to evaluate the effects of AIs on bone metabolism and mineral density at 12 and 24 months.Methods: Among 400 women on AIs who attended our Endocrinology Unit from 2014 to 2016, we retrospectively evaluated those who initially refused antiresorptive and took cholecalc...

ea0063p515 | Calcium and Bone 2 | ECE2019

Denosumab, alendronate and zoledronate failure to suppress bone resorption markers in a woman affected by severe osteoporosis and subclinical hypercortisolism due to an adrenal adenoma: A case report

Zavatta Guido , Preiato Valentina Lo , Vandi Giulia , Vicennati Valentina , Di Dalmazi Guido , Pagotto Uberto , Altieri Paola

Context: ß-CTX are considered useful markers of response to denosumab and other anti-resorbtive treatments for osteoporosis. We report an unusual case of a completely absent effect of both denosumab and bisphosphonates on bone resorption markers.Case description: In 2017 a 74-year-old woman sought medical attention at the Endocrinology Unit of Policlinico di SantÂ’Orsola for the evaluation of an adrenal adenoma associated with osteoporosis. Meno...

ea0063p521 | Calcium and Bone 2 | ECE2019

A rare case of cushing disease and hypophosphatasia

Preiato Valentina Lo , Zavatta Guido , Ribichini Danilo , Altieri Paola , Pelusi Carla , Pagotto Uberto

Cushing disease and hypophosphatasia are rare conditions that may be both responsible of an important impairment of bone metabolism with increased fracture risk. We reported for the first time a case of a 43-year-old woman that came at our attention for recent onset of alopecia and amenorrhea. At the anamnesis, she denied any past relevant events and no drug assumption. At the physical examination, she presented rubeosis and facies lunaris and central adipose distribution (wai...

ea0041ep23 | Adrenal cortex (to include Cushing's) | ECE2016

Ascending aorta dilatation in primary aldosteronism: a new deleterious consequence of aldosterone excess

Vicennati Valentina , Zavatta Guido , Pagotto Uberto , Casadio Elena , Di Dalmazi Guido , Eleonora Rinaldi , Pasquali Renato

Introduction: Primary aldosteronism (PA) features a higher prevalence of cardiovascular events and renal complications as compared with essential hypertension. The effects of aldosterone excess on ascending aorta have never been investigated in human subjects.Methods: From August 2014 to December 2015, we enrolled forty-seven consecutive PA outpatients who had not undergone surgery of the adrenal mass. Hypercortisolism and pheochromocytoma were excluded....

ea0063gp110 | Calcium and Bone 2 | ECE2019

Denosumab in post-liver transplantation osteoporosis: preliminary data on the effects on bone mineral density and turnover markers

Zavatta Guido , Vandi Giulia , Di Dalmazi Guido , Repaci Andrea , Ravaioli Matteo , Cescon Matteo , Morelli Maria Cristina , Pagotto Uberto , Altieri Paola

Introduction: Several risk factors are involved in post-liver transplantation osteoporosis. Immunosuppressive agents, glucocorticoids, decreased renal function associated with secondary hyperparathyroidism and immobilization are the main determinants of fragility fractures in this population. Denosumab is highly effective in increasing bone mineral density (BMD) and preventing fragility fractures. However, the efficacy of denosumab in liver transplantation osteoporosis has nev...

ea0056oc5.2 | Diving deep into adrenal cortex diseases | ECE2018

Steroid profiling by liquid chromatography tandem mass spectrometry in a large cohort of patients with adrenal incidentalomas

Di Dalmazi Guido , Fanelli Flaminia , Zavatta Guido , Rinaldi Eleonora , Casadio Elena , Bitti Silvia Ricci , Mezzullo Marco , Vicennati Valentina , Pagotto Uberto

Background: Steroid profiling by mass spectrometry (MS) provided novel insights into the pathogenesis of adrenocortical tumors and hypercortisolism. The aims of the study were (I) to analyze the steroid profiling by liquid chromatography-tandem MS (LC-MS/MS) in a large cohort of patients with adrenal incidentalomas and (II) to investigate the relationship between steroid profile and clinical outcomes.Methods: We included 307 patients with mono- and bilat...