Endocrine Abstracts

Background: Acanthosis nigricans (AN) is a cutaneous condition characterised by pigmented hyperkeratosis of the skin flexures and neck and occurs most commonly in association with hyperinsulinaemia and insulin resistance (IR). A high prevalence of hyperinsulinaemia and abnormal glucose intolerance has been reported in the Emirati population. Current knowledge of AN suggests that it is a strong visible cutaneous marker associated with IR and can precede the onset of hyperglycae...

Introduction: Definitive treatment of hyperthyroidism with Radioactive Iodine (RAI) ablation therapy has been associated with weight gain from RAI induced hypothyroidism. Literature on weight data of post-RAI patients following normalisation of thyroid function is equivocal.Objective: We undertook a retrospective study to evaluate the effect of RAI on weight in Hyperthyroid patients in University Hospitals of Leicester NHS Trust (UHL). <p class="abst...

Introduction: Adrenal haemorrhage (AH) carries high mortality and morbidity. It can be unilateral or bilateral (BAH), trauma or non-trauma (NT) related. The predisposing factors include adrenal tumours, anticoagulation, thrombocytopenia, sepsis, thromboembolic disease, pregnancy, liver transplant and vaccine-induced-immune-thrombocytopenia-and-thrombosis. BAH can result in an adrenal crisis in up to 15%. BAH is usually associated with conditions contributing to adrenal vein sp...

Introduction: Type 2 diabetes, obesity and fatty liver disase are the most common comorbidities at the orgin of metabolic syndrome. Treatment of these conditions overlaps significantly. The most recent innovation in the armamentarium of pharmacotherapy of type 2 diabetes is Glp 1 agonist, More recent research on the effect of GLP-1 receptor agonist on weight loss, metabolic parameters and fatty liver disease are promising. The weight reduction offered by GLP-1 agonist treatmen...

Introduction: Despite Egypt being a sunny country (latitude 22–32°N) and enjoying a high year-round UV exposure (highest UV index in Cairo 12 in July and lowest 3 in December), it harbors a high prevalence of vitamin D deficiency especially in females (Botros et al, Endocrinol Nutr, 2015;62(7):314–321).Aim of work: We aimed to study a larger representative sample of Egyptian males and females, to identify the extent of the phenomenon and c...

Three phenotypes of prediabetes are known: impaired fasting glucose (IFG), Impaired glucose tolerance (IGT), and combined IFG/IGT. IFG is associated with impaired early phase and normal second-phase of insulin secretion. IGT is associated with both impaired early and late phase of insulin secretion. Numerous studies have demonstrated efficacy of lifestyle intervention in improving 2-hr oral glucose tolerance and fasting plasma glucose (FPG) in individuals with prediabetes, whi...

Objective: Pituitary stalk interruption syndrome (PSIS) is a rare congenital abnormality of the pituitary that is responsible for multiple anterior pituitary hormone deficiencies with the estimated incidence of 0. 5/100,000 live births. We report the a case of PSIS from Saudi Arabia.Case report: A 16 year old Saudi boy with short stature and undescended testis, status post bilateral orchidopexy presented to our endocrine clinic. He was delivered by caesa...

Pheocromocytomas (PHEO) are catecholamine secreting tumours which can occur sporadically or as part of other hereditary/familial syndromes including Neurofibromotosis 1 (NF-1). Unlike the case with other genetic syndromes, the current neurofibromatosis guidelines do not recommend a routine hormonal screening strategy for PHEO in the absence of hypertension or other symptoms. In this paper we describe 2 asymptomatic and normotensive patients with NF-1 where secretory PHEO were ...

The standard management for Grave’s thyrotoxicosis includes the use anti-thyroid drugs, surgery and radioactive iodine treatment. In certain situations,alternative methods including bile acid sequestrants and therapeutic plasma exchange (TPE) have proven effective especially when other treatment modalities fail. We describe a case where conventional and alternative non-invasive measures failed to restore an euthyroid state and resorted to emergency thyroidectomy. A 49 yea...

A 50 year old male presented with left visual field loss, afferent pupillary defect and reduced libido in 1999. Initial pituitary profile showed prolactin 130 000 mu/l (55.4–276), and testosterone was 5 nmol/l (10–27.6). MRI pituitary showed giant pituitary macroadenoma compressing chiasm. He was started on Cabergoline with subsequent improvement in visual fields, prolactin levels and size of adenoma on subsequent MRI. His disease remained stable on ...