Endocrine Abstracts

Acylation stimulating protein (ASP) synthesis occurs through the interaction between complement C3, factor B and adipsin in adipose tissue. ASP demonstrates potent lipogenic effects that are modulated by sex hormones in vivo and in vitro. In this study, an ex vivo investigation was carried out to analyse expression of genes related to ASP production and function. Adipose tissue was harvested from ovariectomized rats (n=6), and treated with s...

Introduction: Hyperglycaemia induced elevation in alanine aminotransferase (ALT) in people with type 1 diabetes has been well described in children but is a less recognised complication in adults.CaseAn 18 year old slim girl was admitted to hospital with diabetic ketoacidosis (DKA). She had type 1 diabetes for 16 years and recurrent hospital admissions with DKA. Her HbA1C was 126 mmol/mol. After correction of her DKA and restarting...

Background: There is a strong association between type II diabetes mellitus (DM) and gaining weight. Lifestyle modification is an important factor for weight management to overcome the obesity as well as DM epidemics.Aim of study: To find the differences of eating habits and Rosenberg Self-Esteem between DM patients and control and to find the strongest contributor of risk factors by study groups.Methods: A hospital-based matched c...

Objective: This study was planned to examine the effect of galangin on hyperglycemia mediated oxidative stress in streptozotocin (STZ)-induced diabetic rats.Methods: Diabetes was induced by intraperitoneal administration of low dose of STZ (40 mg/kg body weight (BW)) into male albino Wistar rats. Galangin (8 mg/kg BW) or glibenclamide (600 μg/kg BW) was given orally daily once for 45 days to normal and STZ-induced diabetic rats.<p class="abstext...

Background: Evidence suggests associations between vitamin D deficiency and cardiovascular risk factors, including hypertension and excessive cortisol levels. Also, vitamin D levels may be associated with exercise performance. Thus, we aimed to investigate the effects of vitamin D intake on cardiovascular risk factors, free urinary cortisol and exercise performance.Methods: A randomised placebo controlled single-blinded parallel trial was conducted in he...

The synthesis and metabolism of bile acids and steroid hormones are conflicted at several levels. We investigated potential interactions using a feeding paradigm to stimulate bile acid secretion and salivary steroid measurements to monitor post-prandial changes.The study followed a randomised cross over design; both cortisol and cortisone were measured by specific ELISAs to assess effects on 11 beta-hydroxysteroid dehydrogenase activity (11βHSD). At...

AbstractBackground: β-cell apoptosis is a cardinal feature of type 1 diabetes. A20 is an important negative regulator of inflammation and apoptosis and protects against β-cell death in response to inflammatory cytokines, and β-cell rejection following islet transplantation1. Preliminary experiments showed rapid induction of A20 (15–60 min) in β-cells in response to treatment with TNFα. Experimenta...

We present a 41 years old lady who presented with non specifc symptoms- lethargy, general myalgia, memory impairment. She also complained of hot flushes, sweats and had a brief episode of panic attacks hence was commence on Sertraline by the GP. She has a past medical history of appendicectomy. Her mother had lymphoma and mother died from lung cancer. She is a smoker, however is teetotal. She has 3 children and works in a laundry. She was initially referred to the haematologis...

Introduction: Ongoing scientific research indicates that there is a dangerous link between eating foods that contain gluten and Hashimoto’s thyroiditis (HT). Gluten can be an irritant to HT by creating inflammation in the thyroid gland. Selenium, an important oligoelement, is a component of the antioxidant system. Over the last decade, it has been ever more frequently discussed in the context of thyroid disorders. The purpose of this study was to highlight the positive r...

Background: Although risk factors for diabetic foot ulceration (DFU) have been extensively studied in patients with diabetes in Egypt, there is surprisingly limited evidence among those on chronic hemodialysis (CHD).Aims: To investigate the risk factors for foot ulceration in adult patients with diabetes with end stage renal disease on hemodialysis in Dakahlia Governorate central hemodialysis units.Patients and methods: This Cross-...