Endocrine Abstracts

Here we discuss two cases of adverse systemic effects of inhaled corticosteroids.A 38-year-old lady presented with lethargy and was noted to be cushingoid, with round face, central adiposity, and bruising. She had history of allergic rhinitis and asthma. She was receiving beclometasone both as nasal spray 100 μg b.d, and as inhaler 400 μg b.d. for the last 10 years. She had only received, a one-week course of oral steroids for acute asthma in t...

Androgens are increasingly known to play an important role in female health, development and well being. Alongside a controversial increase in androgen therapy there is a realisation that what actually constitutes androgen insufficiency is poorly understood. The aim of this study was to establish circadian profiles for salivary testosterone in healthy women from the age of 19 through 69 year old at 3 points during the menstrual cycle. Females were subdivided into these groups:...

There have been several case reports over the years of hypopituitarism occurring after cerebral oedema caused by diabetic ketoacidosis (DKA). The case reports have ranged from a single hormone defect to a more extensive loss of hormone production. What is not reported in the literature so far is what happens to these patients and their hormone deficiencies in the longer term.This is a case report of a young man who presented with DKA aged twelve who rapi...

The aim of this study was to determine if a change in the amount of fat consumed in the diet influenced female salivary postprandial testosterone and cortisol concentrations and whether any changes affected circadian rhythm.The study was conducted on 9 healthy female subjects aged 21–45 years (BMI mean=22.5±1.61) and has been approved by the University College Ethical Committee. Over 3 non-consecutive days, each subject consumed 2 meals, lunch...

Does Iodide Modulate The Biological Outcome of Activating Thyrotropin Receptor Mutations?Dr. F. Al-Khafaji and Dr. M. LudgateHyperthyroidism is caused by pathogenic activation of the thyrotropin receptor (TSHR) either by the thyroid stimulating antibodies of Graves' disease (GD) or activating TSHR mutations. These produce nodular goitre or familial hyperthyroidism. The pathogenic mechanism predominating varies according to the iodide intake, with nodular goitre account...

Background: Polycystic ovarian syndrome (PCOS) is a multifactorial condition with metabolic-related complication, including chronic renal disorder, which is the leading cause of renal transplant globally. HDAC inhibitors (HDACi) have been suggested to protect renal function against biological assaults. Nonetheless, the current study investigated the restorative role of HDACi, butyrate in experimental PCOS-induced renal disorder.M...

Nitric Oxide (NO) has been considered a very important molecule in the biological system because of its interaction with other molecules for mediating various bio-pathways. Its interaction with vitamin D in particular studied well in animal models, cell lines and patients with various diseases. However, the relationship between NO and vitamin D has never been studied in healthy adolescents. We aimed to determine the association of NO with vitamin D and other serological factor...

Introduction: The triad of diabetic ketoacidosis (DKA), acute pancreatitis (AP), and hypertriglyceridaemia (HTG) has been described mainly in T1DM with few cases in T2DM. We report the first case of this triad revealing T2DM.Case report: A 30-year-old male with strong family history of T2DM presented to the emergency with severe epigastric pain radiating to the back associated with abdominal swelling, vomiting and diarrhea. He also reported history of po...

Background: Wide range of biochemical and hematological laboratory values changed during diabetic pregnancy comparable to physiological pregnancies. hyperglycemia is a risk factor for fetal macrosomia. The level of maternal triglycerides have been strongly correlated with excess fetal growth and large for gestational age.Aim of the study: The aim of this study is to evaluate the effect of maternal hyperglycemia and triglycerides on pregnancy outcome in d...

Fasting of Holy month of Ramadan may be beneficial for patients with Type-2 diabetes but patient education and advice is of paramount importance to offset any effect from changing of dietary habits and treatment schedule. We conducted a questionnaire study few weeks before, during Ramadan and few weeks after Ramadan 1424 H/ 2004. A cross sectional random sample of patients with diabetes attending our services was analyzed. 50 patients mean age 65 yeas (20–83), (median, ra...