Endocrine Abstracts

Introduction: Adrenal venous sampling (AVS) is the reference standard test to differentiate between unilateral and bilateral adrenal diseases in patients with primary hyperaldosteronism. Current Endocrine society guidelines recommend AVS in all cases of primary hyperaldosteronism where surgery is desirable and practical. However, this procedure is technically challenging and failure rate is high.Aims: The aim of this audit was to evaluate success rate of...

A 28 year old female with no significant medical history, 25 weeks into her second pregnancy was referred to endocrinology with adjusted calcium of 2.99 mmol/l. She had a short history of generalised aches and tiredness. Examination did not reveal any stigmata of MEN1 or the HPT-JT syndromes. There was no known family history of endocrine disorders. Her PTH was 7 pmol/l, confirming primary hyperparathyroidism. As parathyroid Tc-scintigraphy would be contraindicated in pregnanc...

Introduction: Adipokines, such as resistin and fasting-induced adipose factor (FIAF), are implicated in the regulation of insulin sensitivity and regulated by nuclear receptors like peroxisome proliferator activated receptor gamma (PPARγ), and retinoic acid receptor alpha (RARα). Primarily expressed in murine fat, we also showed that these adipokines are expressed in the mouse hypothalamus, as well as in N-1 hypothalamic neurons. We hypothesized that rosiglitazone (R...

Introduction: The Birt–Hogg–Dube syndrome (BHDS) is a rare autosomal dominant genodermatosis characterised by presence of at least one of the following: benign skin fibrofolliculomas, lung cysts with recurrent pneumothoraces or renal tumours. The phenotypic constellation is due to heterozygous germline mutations of the tumour suppressor gene – FLCN, located on 17p11.2, encoding a 579 aminoacid protein termed folliculin. Case reports have described endocrine tumo...

A 25-year lady was referred by her GP with a six-month history of symptoms suggestive of thyrotoxicosis; weight loss, palpitations, heat intolerance and lethargy. She also complained of thirst, polyuria and nocturia. Examination findings included tachycardia, tremor and a moderately enlarged goitre.In clinic, blood tests performed confirmed thyrotoxicosis: TSH<0.05 mU/l (NR 0.3–4.2 mU/l), free T3 >46.1 pmol/l (NR 2.5–5.7 pmol...

Background: Chronic obstructive pulmonary disease (COPD) is defined as a chronic, slowly progressive disease characterized by airflow obstruction that dose not markedly change over several months. Clinical observations in patients with COPD have noticed that those patients have muscular pain accompanied with loss in the bone mineral density which can be assured by Bone Densitometry and some laboratory tests.Aim of the study: To study the use of Bone Dens...

Case history: A 2 year old Pakistani boy born of consanguineous parents was referred for a dermatological opinion as he had total alopecia. He was born with a full crop of hair, which was shaved at 7 days of age as per religious custom and had not grown back. His motor milestones were delayed such that he started crawling at 14 months and was unable to walk independently. His weight was on the 0.4th centile and his height (72 cm) was far below the 0.4th centile. His anterior f...

This study aimed to compare the prevalence of metabolic syndrome (MetS) and its components in different degrees of obesity. A total of 2309 adults (aged 25–75 years) who were referred to a large university general hospital, divided into four groups according to their body mass index (BMI); 1511 subjects were non-obese (BMI<30 kg/m2); 535 subjects were moderate (30≤BMI<35); 176 subjects were severe (35≤BMI<40) and 87 subjects were very se...

The role of environmental and occupational toxins in the aetiology of unexplained infertility remains to be fully explored. Epidemiological studies have implicated heavy metals, including cadmium as having a pathogenic role with studies demonstrating associations between serum levels, testicular function and gonadotrophin levels in large cohort studies. Cadmium toxicity is associated with a complex spectrum of effects. Whilst the renal complications are well described, putativ...

AimsTo identify the risk of foot complications in patients with diabetes.MethodsThis study was carried out on 140 patients with diabetes mellitus, including Iranian and other ethnic minority group. The study groups were identified from a diabetic clinic (hospital-based) and a diabetes research center. Risk in the study sample was assessed based on International working Group on the Diabetic Foot (IWGDF). An e...