Endocrine Abstracts

Introduction: ACTH-secreting pituitary adenoma tissue differs from normal pituitary gland tissue in microRNA (miR) expression. MiRs are secreted into circulation and can be detected as potential biomarkersAim: To evaluate the difference in miR levels in plasma samples drained from inferior petrosal sinuses in patients with Cushing’s disease (CD) and ectopic-ACTH syndrome (EAS).Materials and methods: we enrolled 24 patients wi...

Introduction: Menopause marks a period of significant changes on hormones and on the women’s lifestyle, which can interfere with their subsequent health. Menopause marks not only the end of the woman’s reproductive life, but also the upcoming associated risks for many morbidities, as well. The increasing prevalence of diabetes (either type 1 Diabetes Mellitus (T1DM) or type 2 Diabetes Mellitus (T2DM) renders a necessity to investigate its effects on women’s a...

Introduction: Prolactinomas are rarely found in adolescents under 15 (incidence 0.1/1.000.000). They account for 50% of all types of pituitary adenomas in childhood and adolescence (2% of intracranial tumors). The mean time from onset of symptoms to diagnosis is 2.4 years on average for girls. In cases of macroadenomas, TSH and GH deficiency may coexist. The gold standard primary therapy is dopamine agonists. In case of non-response, or the presence of large prolactinomas with...

Introduction: Postmenopausal virilization with acute onset and rapid progression requires a thorough investigation for the presence of adrenal or ovarian tumor. We present here a challenging case of a radiologically not visible and rare androgen-hypersecreting ovarian tumor.Case report: A 71-year old postmenopausal woman presented to our department for the investigation of terminal hair growth, of recent onset and rapid progression, on the upper lip, chi...

Introduction: To analyze clinical, laboratory and anamnestic data of the patients with Cushing’s disease (CD) we conducted a CD database.Methods: One hundred and eighty patients with CD were investigated in MRRCI from 1975 year. To all of them in 2011 the invitation letter was sent. In only 22 patients we could confirm diagnosis of CD according to their medical documentation. Three patients died to 2011. From 2009 to 2012 in 16 patients CD were newl...

Introduction: Aromatase is encoded by the CYP19 gene and catalyzes the conversion of androgens to estrogens, which in turn regulate skeletal homeostasis. Polymorphisms in the CYP19 gene have been studied for their association with bone mineral density (BMD) in the general population with mixed results.Objectives: To explore the influence of the CYP19 (TTTA)n repeat polymorphism on BMD and serum levels of osteoprotegerin (OPG), receptor activator...

Introduction: Treatment with dopamine agonists in patients with PRL adenomas has been associated with weight loss in short-term studies. However, long-term studies on weight changes are lacking. Taq1A is a restriction fragment length polymorphism considered as a gene marker for the D2DR gene. The presence of at least one A1 allele is linked to reduced brain dopaminergic activity due to reduced receptor binding and lower density of the dopamine two receptor.<p clas...

The aim of our study was to determine the possibility of engraftment and function of the native thyroid tissue in its autotransplantation in the thigh muscle in rabbits. The experiment included 10 animals species Chinchilla Breed at the age of 12–18 months – five females and five males. In order to simulate the animals primary postoperative hypothyroidism animal extrafascial thyroidectomy was performed, and then on the inside of the left thigh of the neurovascular bu...

Introduction: Differentiated thyroid carcinoma (DTC) has generally a good prognosis and is associated with prolonged survival. A minority of patients may have persistent disease and rarely aggravation during f/u. We investigated factors which may influence the persistence of disease in patients who had undergone ablation with I131.Patients and methods: 903 DTC patients were referred in our center from 1968 to 2012. Five hundred and forty-one (...

Introduction: Recently, small medullary thyroid carcinomas (sMTCs) (≤1.5 cm) are frequently diagnosed, occasionally as incidental findings in surgical and autopsy specimens. Their clinical course varies. We examined whether tumor size is a predictor of clinical behavior.Patients and methods: One hundred and one sMTC patients (36.6% males, 47.1% familial) followed-up for 0.9–35 years. Patients were classified according to tumor size (cm) in gro...