Endocrine Abstracts

Abstract withdrawn...

Personalized medicine is a crucial part of modern medicine. As a result, other therapeutic options apart from levothyroxine are considered when treating hypothyroidism. Desiccated thyroid pharmaceuticals, that in addition to thyroxine (T4), contain triiodothyronine (T3), are one of them. ETA recognized the rapid use of desiccated thyroid pharmaceuticals and described specific guidelines for its utilization. The biggest problem of their use is unresolved issues of content that ...

Introduction: Polycystic ovary syndrome (PCOS) is highly prevalent in women with type 1 diabetes mellitus (T1DM), possibly due to premenarchal exogenous hyperinsulinism (supraphysiological doses and nonphysiologic route of insulin administration). Our aim was to determine if PCOS was related to daily or basal insulin dose or T1DM duration.Methods: We examined 47 women with T1DM (mean age 36.02 years, ±6.03) treated with continuous subcutaneous insul...

Introduction: In primary hypothyroidism, the increase in TRH may cause hyperplasia in the pituitary gland. It has been reported that long-standing hypothyroidism might also cause irreversible pituitary damage, which may lead to a deficiency in one or more pituitary hormones. Herein, we report a case with primary autoimmune hypothyroidism causing pituitary enlargement mimicking pituitary macroadenoma and secondary adrenal insufficiency. Case: A 17-year-ol...

Introduction: Giant prolactinomas are rare tumors accounting for 2–16% of all prolactinomas. They may be aggressive and invasive. Rarely, they might not have a suprasellar component and grow downward. Such extension can make it difficult to distinguish pituitary adenoma from other skull base tumors. We present a case that was considered to be chordoma based on clinical and radiological imaging features, but was diagnosed as prolactinoma by pituitary biopsy.<p class="a...

Introduction: Coronavirus disease-19 (COVID-19) pandemic renders high morbidity and mortality. Glucocorticoid excess is characterized by increased susceptibility to infections due to impairment of the innate and adaptive immune system. Manifestations of Cushing disease (CD) including diabetes mellitus (DM), hypertension, and obesity are risk factors for severe COVID-19 disease. We present three CD patients with different clinical courses of COVID-19. The patients’ general...

Aim: Hashimoto Thyroiditis (HT); is the most common form of hpothyroidism in iodine-sufficient regions. Both genes and and environmental factors are involved in the immunopathological process of HT. Our aim in this study is to determine the prevalence of Thyrothropin Receptor (TSHR), Cytotoxic T Lypmhocyte Antigen-4 (CTLA-4) and Interleukin-1 Receptor Antagonist (IL-1RN) gene polymorphisms associated with HT in Turkish population and the relationship of genotype characteristic...

Objective: To determine whether relationship between trace element levels and microvascular complications of type 2 Diabetes Mellitus (T2DM).Methods: One hundred eighteen patients with type 2 DM (mean age: 56±6.2 years) and 40 control subjects (mean age: 40.0±8.8 years) were included in the study. Group 1 (n=40 patients) was composed of patients with no had microvascular complications and it divided into two subgroup, first subgroup (<...

Childhood obesity and its later progression to Type 2 Diabetes (T2DM) are known to be associated with sub-clinical inflammation; although the underlying cause for this is unclear. However, studies suggest that bacterial endotoxin (LPS) derived from commensal bacteria in the human gastrointestinal tract may contribute directly to sub-clinical inflammation. Human adipose tissue expresses toll like receptors that induce an inflammatory cascade in the presence of endotoxin. Hence,...

The aim of the study was to evaluate the safety, feasibility and efficacy of HIFU (High Insensity Focused Ultrasound) for the destruction of thyroid nodules in patients who are indicated for thyroid surgery.Material and methods: 13 patients were treated by a HIFU device 2 weeks before thyroidectomy for euthyroid multinodular goiter. Ultrasound (US) examination was performed before and at 3, 8 and 15 days post treatment. Free T3, T4, TSH, thyroglobulin we...